http://www.nationalboardinstitute.com/members/ordertemple08/activity/ Activity feed for Dalsgaard. Fri, 23 May 2025 17:06:54 -0700 https://buddypress.org/?v=9.1.1 en-US 30 hourly 2 8d75e9f63c0c53878f49226bee88c429 http://www.nationalboardinstitute.com/activity/p/41211/ Fri, 07 Feb 2025 11:50:43 -0800 Antisense oligonucleotide (ASO)-based therapy is one of the next-generation therapy, especially targeting neurological disorders. Many cases of ASO-dependent gene expression suppression have been reported. Recently, we developed a tocopherol conjugated DNA/RNA heteroduplex oligonucleotide (Toc-HDO) as a new type of drug. Toc-HDO is more potent,…[Read more]

]]> 0 c7de3b4df35396e7c33361063919f803 http://www.nationalboardinstitute.com/activity/p/37622/ Mon, 03 Feb 2025 11:36:49 -0800 However, their final height was not compromised when compared to their family height target. We found pubertal delay in 12%; accelerated/precocious puberty in 13.2%; central and primary hypogonadism in 21.9% and 3.3%, respectively; primary and central hypothyroidism in 23.6% and 14.5%, respectively; thyroid nodules in 7.4%; ACTH deficiency in…[Read more]

]]> 0 337e338167350dae103311145a850860 http://www.nationalboardinstitute.com/activity/p/36702/ Sun, 02 Feb 2025 11:42:47 -0800 CD19 is among the most relevant targets in cancer immunotherapy. However, its extracellular domain (ECD) is prone to aggregation and misfolding, representing a major obstacle for the development and analysis of CD19-targeted therapeutics. Here, we engineered stabilized CD19-ECD (termed SuperFolder) variants, which also showed improved expression…[Read more]

]]> 0 70a4d2c470490304ddb9adad6e50713d http://www.nationalboardinstitute.com/activity/p/35855/ Sat, 01 Feb 2025 11:38:22 -0800 Understanding the history of the Greenland Ice Sheet (GrIS) is critical for determining its sensitivity to warming and contribution to sea level; however, that history is poorly known before the last interglacial. Most knowledge comes from interpretation of marine sediment, an indirect record of past ice-sheet extent and behavior. Subglacial…[Read more]

]]> 0 504b043b292c4fc8a1144e37f2e5507a http://www.nationalboardinstitute.com/activity/p/34104/ Thu, 30 Jan 2025 11:48:43 -0800 vitamin D for osteomalacia and anti-osteoporotic osteoporosis regimens will hopefully enhance bone, muscle, and general health, minimizing falls and fractures.Background and aim Gram-negative rods (GNR) are the most common pathogens associated with urinary tract infections (UTI). The resistance of these gram-negative rods to various antibiotics is…[Read more]

]]> 0 a6a36df57debe60297520b7fecc775f3 http://www.nationalboardinstitute.com/activity/p/30784/ Tue, 28 Jan 2025 15:43:02 -0800 0