The Nevada National Board Professional Learning Institute | Fabricius | Activity http://www.nationalboardinstitute.com/members/sawjeff0/activity/ Activity feed for Fabricius. Fri, 23 May 2025 17:06:54 -0700 https://buddypress.org/?v=9.1.1 en-US 30 hourly 2 c14c8e4b60dcc9ed1e6066aefa314552 Fabricius posted an update: The research and monitoring projects with tribal communities […] http://www.nationalboardinstitute.com/activity/p/42705/ Sun, 09 Feb 2025 10:50:25 -0800 The research and monitoring projects with tribal communities taught the collaborating non-Indigenous scientists the value of reciprocity, highlighting both the benefits from and protection of oceans that promote our well-being. Effective global oceans and human health initiatives require a collective action that gives equal respect to all voices…[Read more]

]]> 0 fb81bef3f6b5715ebffaf799e36eb8df Fabricius posted an update: We then demonstrated that PI3K-Akt signaling pathway was […] http://www.nationalboardinstitute.com/activity/p/41774/ Sat, 08 Feb 2025 10:49:30 -0800 We then demonstrated that PI3K-Akt signaling pathway was indeed activated in cardiac hypertrophy. Furthermore, no matter LY294002, an inhibitor of the PI3K/AKT signaling pathway, or Venetoclax, a selective Bcl-2 inhibitor, protected against cardiac hypertrophy. In conclusion, these data indicate that Bcl-2 is involved in cardiac hypertrophy as a…[Read more]

]]> 0 f977ad4bc0c6818492470f59cfdb2073 Fabricius posted an update: In the present study, chitosan-containing nanocomposites […] http://www.nationalboardinstitute.com/activity/p/41036/ Fri, 07 Feb 2025 10:48:40 -0800 In the present study, chitosan-containing nanocomposites were investigated as new antibacterial agents. Magnetite (Fe3O4) nanoparticles (NPs) as well as chitosan (CS)/Fe3O4 nanocomposites (NCs) and graphene(Gr)/CS/Fe3O4 NCs were synthesized by simple hydrothermal method. Their composition, structure and morphology were studied, followed by the…[Read more]

]]> 0 e0509450514482c7338e960384a58dc4 Fabricius posted an update: D620N mutation in the vacuolar protein sorting 35 ortholog […] http://www.nationalboardinstitute.com/activity/p/39964/ Thu, 06 Feb 2025 11:22:00 -0800 D620N mutation in the vacuolar protein sorting 35 ortholog (VPS35) gene causes late-onset, autosomal dominant familial Parkinson’s disease (PD) and contributes to idiopathic PD. However, how D620N mutation leads to PD-related deficits in vivo remains unclear. In the present study, we thoroughly characterized the biochemical, pathological, and…[Read more]

]]> 0 0bc4ece7d9cd40893c78957e3f08728b Fabricius posted an update: Saline-alkali soil has become an important environmental […] http://www.nationalboardinstitute.com/activity/p/38309/ Tue, 04 Feb 2025 10:49:34 -0800 Saline-alkali soil has become an important environmental problem for crop productivity. One of the most effective approaches is to cultivate new stress-tolerant plants through genetic engineering. Through RNA-seq analysis and RT-PCR validation, a novel bZIP transcription factor ChbZIP1, which is significantly upregulated at alkali conditions, was…[Read more]

]]> 0 8cb32ea0693d4e84430aa76a55df333c Fabricius posted an update: Black cohosh extract (BCE) is marketed to women as an […] http://www.nationalboardinstitute.com/activity/p/37445/ Mon, 03 Feb 2025 10:34:22 -0800 Black cohosh extract (BCE) is marketed to women as an alternative to hormone replacement therapy for alleviating menopausal symptoms. Previous studies by the National Toxicology Program (NTP) revealed that BCE induced micronuclei (MN) and a non-regenerative macrocytic anemia in rats and mice, likely caused by disruption of the folate metabolism…[Read more]

]]> 0 b7dd3961b7f2452c3ce170620b33f821 Fabricius posted an update: However, three TMBCs with different spacer lengths did […] http://www.nationalboardinstitute.com/activity/p/36419/ Sun, 02 Feb 2025 10:16:44 -0800 However, three TMBCs with different spacer lengths did cross-link the two residues, resulting in the formation of new cross-linked ND3/49 kDa subunits. Chemical modification of either ND3 Cys39 or 49 kDa Asp160 blocked the dual cross-linking, ensuring the specificity of the cross-linking. Altogether, this study provides direct evidence that the…[Read more]

]]> 0 880ec77b8b496543b2315d07ced95f1c Fabricius posted an update: Membrane proteins are present in a wide array of cellular […] http://www.nationalboardinstitute.com/activity/p/35654/ Sat, 01 Feb 2025 10:32:42 -0800 Membrane proteins are present in a wide array of cellular processes from primary and secondary metabolite synthesis to electron transport and single carbon metabolism. A key barrier to applying membrane proteins industrially is their difficult functional production. Beyond expression, folding, and membrane insertion, membrane protein activity is…[Read more]

]]> 0 7ee156c02221c477c32136ade7acd81c Fabricius posted an update: ib therapy. KIT encoded by KIT harboring a mutation […] http://www.nationalboardinstitute.com/activity/p/34692/ Fri, 31 Jan 2025 10:44:04 -0800 ib therapy. KIT encoded by KIT harboring a mutation c.1725_1733del is a potential therapeutic target for toceranib in canine malignant melanoma. Further investigation of the KIT mutation status and toceranib therapy in canine malignant melanoma will need to be undertaken.

Nephrotic syndrome (NS) is rare in dogs and is characterized by…[Read more]

]]> 0 72fd91c8e5221c55a47af26300cff729 Fabricius posted an update: No disease-modifying therapy is currently available for […] http://www.nationalboardinstitute.com/activity/p/33726/ Thu, 30 Jan 2025 10:25:32 -0800 No disease-modifying therapy is currently available for Parkinson’s disease (PD), the second most common neurodegenerative disease. The long nonmotor prodromal phase of PD is a window of opportunity for early detection and intervention. However, we lack the pathophysiological understanding to develop selective biomarkers and interventions. By…[Read more]

]]> 0 9bf681f8e4f6d7a9f2719c45292e38bd Fabricius posted an update: Individuals infected with human immunodeficiency virus […] http://www.nationalboardinstitute.com/activity/p/32307/ Tue, 28 Jan 2025 18:14:24 -0800 Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4+ T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4+ T cells from patients with HIV-1 and revealed that the elevated oxidative phosphorylation (OXPHOS) pathway is associated with poor outcomes.…[Read more]

]]> 0 99066b7f2f1b45417f5a341e87d249b0 Fabricius became a registered member http://www.nationalboardinstitute.com/activity/p/32276/ Tue, 28 Jan 2025 18:10:56 -0800 0