Activity

Concerning perinatal medical protocols and psychological services, what service needs and gaps do women’s experiences reveal? The nine perinatal women (one pregnant, eight postpartum), residing in central Canada, and reporting interpersonal trauma from adolescence to their perinatal periods, were subject to in-depth semi-structured qualitative…[Read more]

Aim To evaluate the role of vitronectin-enriched protein corona on systemic delivery of siRNA-encapsulated cationic lipid nanoparticles (LNPs) to αvβ3 integrin expressing solid tumors. Materials & methods 1,2-Dioleoyl-3-trimethylammonium-propane LNPs were formulated, protein corona formed in nude mice serum and its impact on drug delivery were a…[Read more]

Platelet activation and aggregation are essential to limit blood loss at sites of vascular injury but may also lead to occlusion of diseased vessels. The platelet cytoskeleton is a critical component for proper hemostatic function. Platelets change their shape after activation and their contractile machinery mediates thrombus stabilization and…[Read more]

This infusion given prior to context preexposure but not training abolished retention test freezing, with no difference between MK-801-infused rats and non-associative controls preexposed to an alternative context (pooled across drug). These results demonstrate a role of prefrontal NMDA-receptor plasticity in the acquisition and/or consolidation…[Read more]

This paper evaluates the role of socio-cultural issues in developing climate information services that are accessible and engaging to urban communities. Two public-facing city-level climate information provision initiatives in Japan are evaluated in light of theory in environmental risk communication. The first case is Fukuoka City, Kyushu, in…[Read more]

Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism. We aimed to investigate the effect of an FGF21 analogue (LY2405319) on the development of atherosclerosis and its associated parameters. ApoE-/- mice were fed an atherogenic diet for 14 weeks and were randomly assigned to control (saline) or FGF21 (0.1…[Read more]

gency.

Initial procalcitonin (PCT) levels may fail in mortality and septic shock prediction and raise cost-effectiveness issues. Since measurement of lactate, C-reactive protein (CRP), white blood cells and neutrophils is common in the emergency department (ED), we compared prediction abilities of these biomarkers to PCT.

From January…[Read more]

Implications for clinical intervention include recognizing that assaults involving substance use and force are traumatic and warrant individualized treatment.Hepatitis C virus and alcoholic liver disease are major causes of chronic liver diseases worldwide. Little is known about differences between chronic hepatitis C and alcoholic liver disease…[Read more]

To determine effectiveness of proprioceptive training and conventional physical therapy in managing patients with adhesive capsulitis.

A pre-test post-test control group study was conducted at Rehman Medical Institute from June to December 2019. Thirty-eight patients, aged 30 to 60 years, with diagnosis of adhesive capsulitis for more than…[Read more]

Besides, we demonstrated that GTF2E2 knockdown inhibited LUAD cell proliferation, migration, invasion, and promote apoptosis in vitro, as well as attenuated tumor growth in vivo. Results from LC-MS/MS suggested that RPS4X might physically interact with GTF2E2 and mediated GTF2E2’s regulatory effect on LUAD development through the mTOR…[Read more]

Photosynthetic microalgae not only perform fixation of carbon dioxide but also produce valuable byproducts such as lipids and pigments. However, due to the lack of effective tools for rapid and noninvasive analysis of microalgal cellular contents, the efficiency of strain screening and culture optimizing is usually quite low. This study applied…[Read more]

We address the existence and stability of two types of asymmetric dissipative solitons, including fundamental and dipole solitons, supported by a waveguide lattice with non-uniform gain-loss distributions. Fundamental solitons exist only when the linear gain width is greater than or equal to the linear loss width, while dipole solitons exist only…[Read more]

The toxicity characteristics of HBCD and resistance mechanism of flavonols are investigated based on physiological and metagenomic analysis. Toxicology research of HBCD on Arabidopsis thaliana (Col and fls1-3) not only shows the toxic effect of HBCD on plants, but also indicates that flavonols could improve plant resistance to HBCD, including root…[Read more]

The purpose of this study was to assess differences in the physiological profiles of completers vs. non-completers following a structured exercise programme (SEP) and the ability to predict non-completers, which is currently unknown in this group.

Sixty-nine patients met the Fukuda criteria. Patients completed baseline measures assessing…[Read more]

Therefore, our studies suggest the regulatory role of this domain in different aspects of neurodegenerative diseases. Upon HDAC6 ZnF UBP treatment, inactive phosphorylated form of GSK-3β increases without any change in total GSK-3β level.

HDAC6 ZnF UBP was found to be involved in cytoskeletal re-organization by modulating actin dynamics a…[Read more]

A key way to prevent undesirable fouling of any structure in the marine environment, without harming any microorganisms, is to use a polymer film with high hydrophobicity. The polymer film, which was simply prepared from a blend of hydrophobic polydimethylsiloxane elastomer and hydrophilic polyurethane, showed improved properties and economic…[Read more]

A relatively common polymorphism in the human brain-derived neurotrophic factor (BDNF) gene (Val66Met, which corresponds to Val68Met in mice) has been shown to modulate cognitive function and vulnerability to mental health disorders. This substitution impairs trafficking and activity-dependent release of BDNF. A number of studies with both humans…[Read more]

Carers of adults on the autism spectrum often experience high levels of stress, worry, and caregiver burden. There are few studies identifying the predictors of carer mental well-being and none have been conducted in Australia. Data from the Autism Cooperative Research Centre for Living with Autism’s Australian Longitudinal Study of Autism in…[Read more]

001), high-sensitivity C-reactive protein (p=0.001), D-dimer (p<0.001), white blood cells (p<0.001), neutrophils (p=0.001), declining lymphocytes (p<0.001), and natural killer cells (p=0.005) were associated with cardiac injury and showed predictive ability in the multivariate logistic regression.

Our results suggest that age and…[Read more]

cognitions in youth, with age-related differences in their frequency. ‘Avoidance’ behaviours are specifically associated with negative outcomes for quality of peer relationships.The results of numerical simulations of cardiac electromechanics are typically characterized by a long transient before reaching a periodic solution known as limit cycle.…[Read more]