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I then discuss metaphorical extensions of elevational demonstratives to non-spatial uses such as temporal and social deixis. There are a few languages in which elevational demonstratives with the meaning UP express the temporal meaning future, whereas the DOWN demonstratives encode past. This finding is particularly interesting in view of the…[Read more]

The thin-film rotating disk electrode (TF-RDE) is a well-developed, conventional ex situ electrochemical method that is limited by poor mass transport in the dissolved phase and hence can only measure the kinetic response for Pt-based catalysts in a narrow overpotential range. Thus, the applicability of TF-RDE results in assessing how catalysts…[Read more]

74; 95% CI, 0.53-1.04; P=0.08) and high muscle-low fat mass (HR, 0.40; 95% CI, 0.21-0.77; P=0.01) were associated with lower CVD. Further, in adjusted competing risks analyses stratified by sex, the CVD rate in women tends to significantly decrease as normalized total fat increase (total fat fourth quartile HR, 0.56; 95% CI, 0.34-0.94; P less then…[Read more]

Older age, being male, older age of first ideation and greater family support were associated with a slower transition.

The current study suggests that pre-existing mental or substance use disorders, particularly drug use disorder, as well as sexual minority status, sex and greater family support play an important role in the transition…[Read more]

The original article [1] contained an error whereby the captions to Fig. 3 and Fig. 8 were mistakenly interchanged.BACKGROUND Patients’ pre-operative health and physical function is known to influence their post-operative outcomes. In patients with knee osteoarthritis, pharmacological and non-pharmacological options are often not optimised prior…[Read more]

Furthermore, we found that X and Y sperm showed differences in piRNA clusters distributed in the genome as well as piRNA and tsRNA abundance, two tsRNAs (tRNA-Ser-AGA and tRNA-Ser-TGA) had lower abundance in X sperm than Y sperm (p less then 0.05). Overall, our work describes the different sncRNA profiles of X and Y sperm in cattle and enhances…[Read more]

Leptomeningeal metastases (LMs) are a critical neurological manifestation of solid organ malignancies. Early diagnosis and prompt treatment is necessary to improve outcomes. We classified LM on the basis of cytological or histological and imaging studies. A total of 14 patients of LM from solid organ malignancies diagnosed between July 2016 and…[Read more]

There were small differences in the dissolved masses of Ag+ between products, but we did not observe any significant differences in the dissolution trends obtained for deionized water and tap water. The decrease of the dissolved mass of Ag+ in tap water could be due to the reaction between Ag+ and Cl-, forming AgCl and affecting their dissolution.…[Read more]

At test-retest, no significant difference was found for all items. The median total score interquartile range (IQR) of the M-MALMAS was 7.0 (6.0-8.0) and this was significantly correlated to the median total score of the Malay MMAS-8 [median (IQR) = 7.0 (5.8-8.0), p less then 0.001]. HbA1c levels were significantly lower among participants who…[Read more]

sRNAs are a taxonomically-restricted but transcriptomically-abundant class of post-transcriptional regulators. While of major importance for adaption to the environment, we currently lack global-scale methodology enabling target identification, especially in species without known RNA hub proteins (e.g. Hfq). Using psoralen RNA cross-linking and…[Read more]

Body composition may explain partially why non-obese individuals still at the risk of developing non-alcoholic fatty liver disease (NAFLD). The ratio of fat mass to fat-free mass (FM/FFM) has been proposed to assess the combined effect of different body compositions.

We aimed to investigate the associations of FM/FFM ratio with the risk of…[Read more]

In this review, our purpose is to summarize what has been learned to date regarding SpA genetics from family-based studies, with a special focus on recent identification of rare associated variants through next-generation sequencing studies.Ductal carcinoma in situ (DCIS) is a preinvasive form of breast cancer with a highly variable potential of…[Read more]

A major challenge for the development of a wearable artificial kidney (WAK) is the removal of urea from the spent dialysate, as urea is the waste solute with the highest daily molar production and is difficult to adsorb. Here we present results on glucose degradation products (GDPs) formed during electrooxidation (EO), a technique that applies a…[Read more]

females, which may be related to the observed sex difference in CVD risk in T1DM.

Children with congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) require daily hydrocortisone replacement with accurate dosing.

Prospective study of efficacy and safety of hydrocortisone granules in children with AI and CAH monitored by…[Read more]

After identifying important predictors of nucleotide diversity with random forest regression, we conducted follow-up analyses to examine the roles of phylogenetic history, geography, and demographic processes on intraspecific diversity. Although life history traits were not important predictors for this data set, we found significant phylogenetic…[Read more]

The search for therapeutic strategies to promote neuronal regeneration following injuries toward functional recovery is of great importance. Brief low-frequency electrical stimulation (ES) has been reported as a useful method to improve neuronal regeneration in different animal models; however, the effect of ES on single neuron behavior has not…[Read more]

Level of evidence grading has become widely used in orthopaedics. see more This study reviewed clinical research articles published in leading orthopaedic journals to describe the association between level of evidence and number of future citations, which is one measure of an article’s impact in the field.

The first 100 clinical research…[Read more]

The TNM staging system for oral squamous cell carcinoma (OSCC) provides clinicians a dependable foundation for patient prognosis and management decisions, but in clinical practice, treatment outcomes of patients with OSCC are sometimes unsatisfactory. This retrospective study investigated the association between survival and clinicopathological…[Read more]

Self-assembly of the amyloid-β (Aβ) peptide into aggregates, from small oligomers to amyloid fibrils, is fundamentally linked with Alzheimer’s disease (AD). However, it is clear that not all forms of Aβ are equally harmful and that linking a specific aggregate to toxicity also depends on the assays and model systems used (Haass et al., J Biol. Ch…[Read more]

Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic changes; however, the metabolic side effects produced by aripiprazole are more benign. The aim of the study was to evaluate if aripiprazole and olanzapine alter prolactin levels, lipid and glucose metabolism and hepatic, haematological, thyroid and renal…[Read more]