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Extending these in vitro and ex vivo observations, some prebiotics have been well investigated, with successful human and animal trials demonstrating the association between gut microbes and immunity biomarkers leading to improvement in health endpoints across populations. This review discusses scientific insights into the association between prebiotics, innate immunity and gut microbiome from in vitro to human oral intervention.The reaction of [Cp”’Ni(η3 -P3 )] (1) with in situ generated phosphenium ions [RR’P]+ yields the unprecedented polyphosphorus cations of the type [Cp”’Ni(η3 -P4 R2 )][X] (R=Ph (2 a), Mes (2 b), Cy (2 c), 2,2′-biphen (2 d), Me (2 e); [X]- =[OTf]- , [SbF6 ]- , [GaCl4 ]- , [BArF ]- , [TEF]- ) and [Cp”’Ni(η3 -P4 RCl)][TEF] (R=Ph (2 f), tBu (2 g)). In the reaction of 1 with [Br2 P]+ , an analogous compound is observed only as an intermediate and the final product is an unexpected dinuclear complex [Cp”’Ni2 (μ,η3 η1 η1 -P4 Br3 )][TEF] (3 a). APG-2449 ALK inhibitor A similar product [Cp”’Ni2 (μ,η3 η1 η1 -P4 (2,2′-biphen)Cl)][GaCl4 ] (3 b) is obtained, when 2 d[GaCl4 ] is kept in solution for prolonged times. Although the central structural motif of 2 a-g consists of a “butterfly-like” folded P4 ring attached to a Cp”’Ni fragment, the structures of 3 a and 3 b exhibit a unique asymmetrically substituted and distorted P4 chain stabilised by two Cp”’Ni fragments. Additional DFT calculations shed light on the reaction pathway for the formation of 2 a-2 g and the bonding situation in 3 a.N-heterocyclic carbenes (NHCs) have received significant attention as gold nanoparticle stabilizers due to their strong binding affinity towards gold. However, their tunability is limited by the difficulty in obtaining nonsymmetric NHCs. In this regard, N-acyclic carbenes (NACs) are attractive alternatives due to their high synthetic versatility, allowing easy tuning of their steric and electronic properties towards specific applications. This work reports the first series of stable and monodisperse NAC-functionalized gold nanoparticles. These particles with sizes ranging 3.8 to 11.6 nm were characterized using NMR, UV/Vis and TEM. The nanoparticles display good stability at elevated temperatures and for extended periods both dried or dispersed in a medium, as well as in the presence of exogenous thiols. Importantly, these NAC-stabilized gold nanoparticles offer a promising and versatile alternative to NHC-stabilized gold nanoparticles.Limited statistical power due to small sample sizes is a problem in fMRI research. Most of the work to date has examined the impact of sample size on task-related activation, with less attention paid to the influence of sample size on brain-behavior correlations, especially in actual experimental fMRI data. We addressed this issue using two large data sets (a working memory task, N = 171, and a relational processing task, N = 865) and both univariate and multivariate approaches to voxel-wise correlations. We created subsamples of different sizes and calculated correlations between task-related activity at each voxel and task performance. Across both data sets the magnitude of the brain-behavior correlations decreased and similarity across spatial maps increased with larger sample sizes. The multivariate technique identified more extensive correlated areas and more similarity across spatial maps, suggesting that a multivariate approach would provide a consistent advantage over univariate approaches in the stability of brain-behavior correlations. In addition, the multivariate analyses showed that a sample size of roughly 80 or more participants would be needed for stable estimates of correlation magnitude in these data sets. Importantly, a number of additional factors would likely influence the choice of sample size for assessing such correlations in any given experiment, including the cognitive task of interest and the amount of data collected per participant. Our results provide novel experimental evidence in two independent data sets that the sample size commonly used in fMRI studies of 20-30 participants is very unlikely to be sufficient for obtaining reproducible brain-behavior correlations, regardless of analytic approach.Rearrangement reactions are certainly one of the most useful approaches towards complex structures in organic chemistry. With efficient conditions, it is indeed possible to convert simple substrates into highly functionalized products. Moreover, combining this approach with an attractive initiation process, such as visible-light catalysis, makes these reactions particularly powerful. Recently, tremendous improvements have been made, owing to a better understanding of photoredox mechanisms. In this review, recent progress on visible-light aryl migration reactions is discussed, focusing especially on Smiles rearrangement and related reactions.The aim of this study was to elucidate the morphological characteristics of the lateral Lisfranc ligament in a large sample. This investigation examined 100 legs from 50 cadavers. Each of the lower limbs was dissected to identify the plantar aspect of the transverse metatarsal arch, and morphological characteristics of the lateral plantar ligament were assessed, including the length, width, and thickness of the fiber bundles. The majority of plantar ligaments originated from the base of M5 and the plantar aspect of the lateral cuneiform (LC). The lateral plantar ligament could be classified into three types Type I, a band-like fiber bundle originating from the base of M5 to the LC (41%); Type II, originating from the base of M5 and the plantar aspect of LC and mostly connected the blending the fiber bundles of the tibialis posterior (TP) and long plantar ligament (LPL) (21%); and Type III, with no ligaments originating from the base of M5 and plantar aspect of the LC (38%). The morphological characteristics of Type I lateral plantar ligament were as follows length, 31.8 ± 3.7 mm; width, 2.3 ± 1.0 mm; and thickness, 0.2 ± 0.3 mm. The morphology of the lateral plantar ligament showed variation, originating from the base of M5 and the plantar aspect of LC most commonly, but this was not the case in 38% of limbs. The findings suggest that the lateral plantar ligament might play a role in the transverse tarsal arch, indicating a cooperative mechanism with the TP and LPL.