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TTM is an effective treatment that can lower the risk of neurological disability in such patients and ideally delivered as part of a comprehensive, goal-directed post-resuscitation management by a multidisciplinary team in a tertiary medical center.

There is substantial risk of neurological injury in cardiac arrest survivors who remain comatose. read more TTM is an effective treatment that can lower the risk of neurological disability in such patients and ideally delivered as part of a comprehensive, goal-directed post-resuscitation management by a multidisciplinary team in a tertiary medical center.Japanese diaspora archaeology originated in the late 1960s but reports and publications did not appear until the 1980s. Early studies often included Japanese artifacts or sites within larger surveys, but by the 1990s and 2000s were the focus of targeted research. Most research has been undertaken in western North American and the Pacific Islands. Pre-War farms and work camps and World War II battlefields and incarceration centers emerged as primary topics of study, with the incarceration centers dominating the literature today. Research themes are diverse but emphasize material consumption, concepts of place, and patterns of cultural persistence and change.The paper aims to address the development of China’s narrative power during the COVID-19 pandemic and its impact on world order. It argues that in the post-pandemic world, the emergence of the authoritarian sub-order would be prompted by China’s more proactive narrative power, given that the climate of opinion is ambiguous when faced with the uncertainty of the pandemic. (This does not imply the end of the existing liberal order; instead, it features the coexistence of both orders.) To understand how China’s narrative power has encouraged the emergence of the authoritarian sub-order to coexist in parallel with the dominant constitutional order, the article first reviews the existing literature concerning the changing world order. In this section, it also briefly defines and differentiates between the constitutional and authoritarian orders, what defines world order, and what distinguishes authoritarian from constitutional liberal order. Second it looks at the theoretical grounding. The nature, role and power of narratives are explored. Ideas about strategic narratives and the economics of attention are discussed. This theoretical background paves the way to examine China’s narrative power during a pandemic. Lastly, it switches to the Chinese perspective to address its support for the plurality of orders and its awareness of the strength of narrative in influencing dominant ideas. It looks at how China’s narrative power has been exercised from three perspectives (formation, projection and reception). Here, it mainly tackles how China has used its narrative power to spin the pandemic to its advantage in the reorganization of world order improving its international image and advocating the authoritarian order as an alternative. China has been building its narrative along with its changing strategic diplomacy – from restrained and low-profile to proactive and assertive. In the conclusion, some reflections on China’s narrative power and the implications for world order are considered.The proteome of exhaled breath condensate was analyzed by mass spectrometry before and immediately after the thermoheliox procedure and after a 3 h relaxation. The major part of the proteome remained unchanged and there was no extensive cell destruction.A kinetic model is proposed to describe the key features of development of an acute viral infection, accumulation of antibodies, and immune response in the human body. The general features of immune system stimulation by thermoheliox are described. The model can be used for developing the basis for the application of thermoheliox in the treatment of patients affected by coronavirus.We present a novel formulation for the calibration of a biophysical tumor growth model from a single-time snapshot, multiparametric magnetic resonance imaging (MRI) scan of a glioblastoma patient. Tumor growth models are typically nonlinear parabolic partial differential equations (PDEs). Thus, we have to generate a second snapshot to be able to extract significant information from a single patient snapshot. We create this two-snapshot scenario as follows. We use an atlas (an average of several scans of healthy individuals) as a substitute for an earlier, pretumor, MRI scan of the patient. Then, using the patient scan and the atlas, we combine image-registration algorithms and parameter estimation algorithms to achieve a better estimate of the healthy patient scan and the tumor growth parameters that are consistent with the data. Our scheme is based on our recent work (Scheufele et al., Comput. Methods Appl. Mech. Engrg., to appear), but we apply a different and novel scheme where the tumor growth simulation in contrast to the previous work is executed in the patient brain domain and not in the atlas domain yielding more meaningful patient-specific results. As a basis, we use a PDE-constrained optimization framework. We derive a modified Picard-iteration-type solution strategy in which we alternate between registration and tumor parameter estimation in a new way. In addition, we consider an ℓ1 sparsity constraint on the initial condition for the tumor and integrate it with the new joint inversion scheme. We solve the sub-problems with a reduced space, inexact Gauss-Newton-Krylov/quasi-Newton method. We present results using real brain data with synthetic tumor data that show that the new scheme reconstructs the tumor parameters in a more accurate and reliable way compared to our earlier scheme.

A shutdown of businesses enacted during the SARS-CoV-2 pandemic can serve different goals, e.g., preventing the intensive care unit (ICU) capacity from being overwhelmed (‘flattening the curve’) or keeping the reproduction number substantially below one (‘squashing the curve’). The aim of this study was to determine the clinical and economic value of a shutdown that is successful in ‘flattening’ or ‘squashing the curve’ in Germany.

In the base case, the study compared a successful shutdown to a worst-case scenario with no ICU capacity left to treat COVID-19 patients. To this end, a decision model was developed using, e.g., information on age-specific fatality rates, ICU outcomes, and the herd protection threshold. The value of an additional life year was borrowed from new, innovative oncological drugs, as cancer reflects a condition with a similar morbidity and mortality burden in the general population in the short term as COVID-19.

A shutdown that is successful in ‘flattening the curve’ is projected to yield an average health gain between 0.