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Feeding and eating disorders in ICD-11 Abstract. Innovations in ICD-11 include the adoption of a lifespan approach and culture-related guidance for each disorder. Atezolizumab We describe the changes made to the chapter Feeding and Eating Disorders and compared them to the ICD-10. In addition to illustrating the revision of the guidelines for each disorder, we also comment on the inclusion of a new set of diagnoses, avoidant/restrictive food intake disorder (ARFID) and binge-eating disorder (BED).This paper examines the planning, execution, and closure of the US-Korea Cooperative Ecological Survey project in the Korean Demilitarized Zone (DMZ) in the 1960s. In this period, the U.S. National Academy of Sciences (NAS) initiated bilateral scientific cooperation between the NAS and similar organizations in developing countries along the line of the developmental turn of U.S. foreign assistance. Working closely with the NAS, U.S. conservationists used this scheme to introduce nature conservation practices and the discipline of ecosystem ecology to developing countries. In this context, by way of the NAS’s Pacific Science Board, two countries’ biologists initiated the preliminary cooperative project in the DMZ in 1966. Korean and U.S. scientists soon began to realize that their collaboration was marked by dissonance. The U.S. side attributed the cooperation failure to Korean culture while the Korean side criticized the unequal structure of their cooperation. Joining the global historiography of Cold War scientific collaboration, this paper pays particular attention to the intermediaries of the collaborative project and their rivalry. It argues that political struggles revolving around the position of go-betweens – as what I call knowledge brokers – on the recipient side provoked contestation between American and Korean scientists. The contention between the two sides played out in the collaboration coming to an end, albeit partially. Throughout this analysis, this study suggests paying more serious attention to the politics of scientific exchange among actors on the recipient side as an outset from which to analyze the heterogeneity of the Korean side without losing sight of their active role in the building process of American hegemony.

Melanoma is the most lethal form of skin cancer with the incidence drastically increasing over the past several decades. (

)-(-)-N-[2-(3-Hydroxy-2-oxo-2,3-dihydro-1

-indol-3-yl)-ethyl]-acetamide (SA) was a new compound isolated from the leaves of

, with potent activities to inhibit the proliferation of SK-mel-110 cells. This study was to further investigate effects of SA against melanoma and explore its underlying mechanisms.

B16 cells were treated with different concentrations of SA. Tumor model was established by injecting B16 cells into C57 mice subcutaneously. MTT and LDH assays were used to detect effects of SA on cell viability. ELISA assay, Annexin V/PI staining and TUNEL assay were used to detect apoptosis. RT-qPCR and western blot were used to detect the expression of genes and proteins, respectively.

SA significantly inhibited the proliferation of melanoma cells and induced the apoptosis as well as autophagy, which may be associated with PI3K/Akt and MAPK signal pathways. Moreover, SA treatment significantly slowed melanoma tumor growth, evidenced by decreased tumor volume and tumor weight.

Our data suggested that SA could be developed as a potential anti-tumor drug against melanoma.

Our data suggested that SA could be developed as a potential anti-tumor drug against melanoma.Background To investigate the effects of 1-month treatment in addition to standard care with a food supplement containing both Curcuma longa and Boswellia serrata extracts on tendinopathy symptoms.Method This open-label, non-controlled, post-observational study included 670 patients suffering from tendinopathy recruited at different sites by Belgian general practitioners. Patients received a medical prescription for 1-month treatment with two tablets twice a day of a pharmaceutical grade food supplement containing both C. longa and B. serrata extracts. Pain and functional limitation were evaluated using a visual analog scale at the inclusion and 1-month treatment later. Patient satisfaction, concomitant drugs intake and side effects were also recorded.Results After 1-month treatment, pain and functional limitation were significantly improved whatever the cause of tendinopathy, its localization, and the duration of symptoms. The pain score decreased from 6.16 ± 1.53 to 2.98 ± 1.64 (p  less then  .0001), yieldid symptomatic treatments.The combination of Curcuminoids and B. Serrata extract is safe and can be administrated for at least 1 month in addition of analgesic and non-steroidal anti-inflammatory drugs.

To evaluate the maxillary and mandibular vertical skeletal asymmetries, and the correlation between these asymmetries and occlusal cant in patients with unilateral cleft lip-palate (UCLP).

Anteroposterior radiographs of 25 patients with UCLP (UCLP group, mean age 20.98 ± 4.88 years) and 25 subjects without cleft (control group, mean age 19 ± 2.86 years) were included. Independent samples

test, Mann-Whitney

test and Pearson correlation analysis were performed based on linear and angular measurements.

Lower facial horizontal asymmetry did not show statistically significant difference between the UCLP and control groups. However, vertical asymmetry of (a) the lateral cranial base (

= .014), (b) the nasomaxillary region (

< .001), (c) the maxillary dentoalveolus (

= .001), and (d) the lower face (

= .038) were all found to be significantly greater in UCLP group. The occlusal cant angle was also significantly greater in patients with UCLP compared to the controls (

= .016). While the occlusal cant angle was found to be correlated with the vertical asymmetry of the occlusal cant (

= 0.931,

< .001), maxillary cant angle was found to be correlated with the vertical asymmetry of the maxillary dentoalveolus (

= 0.655,

< .001).

There was no correlation between the occlusal cant and the vertical and horizontal skeletal asymmetries. Vertical asymmetries of the lower face and the medial cranial base were negatively correlated with the horizontal lower facial asymmetry.

There was no correlation between the occlusal cant and the vertical and horizontal skeletal asymmetries. Vertical asymmetries of the lower face and the medial cranial base were negatively correlated with the horizontal lower facial asymmetry.