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Incorporation of time delay also gives the scenario of double Hopf-bifurcation. Some control parameters are discussed to stabilize system dynamics. The effect of time delay on (i) growth rate of susceptible phytoplankton shows the extinction and double Hopf-bifurcation in the zooplankton population, (ii) a sufficiently large value of carrying capacity stabilizes the chaotic dynamics or makes the whole system chaotic with further increment.Hand, foot and mouth disease is a common viral infectious disease caused by enteroviruses, including coxsackie A16 (CVA16) and enterovirus 71 (EV71). HFMD can cause severe symptoms in children which can be fatal. Human scavenger receptor class B member 2 (SCARB2) is a cellular receptor for EV71 and CVA16, providing a potential approach for preventing EV71 infection and transmission. In this present study, we constructed and assessed the potential of recombinant SCARB2, using E. coli expression system. To generate this construct, scarb2 gene was cloned into pET22b vector and expressed in E. coli BL21 (DE3). The expression of SCARB2 was induced by 0.1 mM IPTG and analyzed using SDS-PAGE, followed by Western blot. Expressed SCARB2 was in inclusion bodies and refolded to obtain the soluble form with recovery efficacy of 100%. This recombinant protein was then validated for binding with EV71 via indirect ELISA in two different pHs (7.4 and 5.5), which partially revealed the mechanism of virus-receptor interaction. These results envisaged potential applications for utilizing recombinant SCARB2 in preventing the virus transmission.Simply monitoring movement of the tailings dam wall does not address the cause of tailings dam failures and will therefore never be an effective method to reduce or prevent failures. Monitoring the causes of failures is more effective. The main cause of tailings dam failure is slope instability, which is caused by too much water in the wrong place. Accurate pore pressure monitoring of the pressure (weight) of water in the tailings storage facility (TSF) slopes and plotting of flow lines beneath and upstream of the TSF can guide and enable early intervention to prevent or delay failure. Remote monitoring linked to artificial intelligence and robotics to turn on pumps and open drains to address and remove the cause of failure can help reduce risk. Installation of multiple point piezometers in an accurate pattern allows the plotting of equipotentials and flow lines in three dimensions. Each TSF is unique and requires its own monitoring design, which should be tailored to match the age, structure, and specific causes of risk. Once understood, the monitoring system can be coupled to a reporting system to significantly reduce the risk of failure at both legacy and active sites.In the COVID-19 pandemic era, undoubtedly mathematical modeling helps epidemiological scientists and authorities to take informing decisions about pandemic planning, wise resource allocation, introducing relevant non-pharmaceutical interventions and implementation of social distancing measures. The current coronavirus disease (COVID-19) emerged in the end of 2019, Wuhan, China, spreads quickly in the world. In this study, an entropy-based thermodynamic model has been used for predicting and spreading the rate of COVID-19. In our model, all the epidemic details were considered into a single time-dependent parameter. The parameter was analytically determined using four constraints, including the existence of an inflexion point and a maximum value. Our model has been layout-based the Shannon entropy and the maximum rate of entropy production of postulated complex system. The results show that our proposed model fits well with the number of confirmed COVID-19 cases in daily basis. Also, as a matter of fact that Shannon entropy is an intersection of information, probability theory, (non)linear dynamical systems and statistical physics, the proposed model in this study can be further calibrated to fit much better on COVID-19 observational data, using the above formalisms.

The association between obesity and the need for open reduction and surgical fixation of the syndesmosis in the setting of malleolar ankle fractures remains to be elucidated. Therefore, the primary objective of this study was to assess the relationship between obesity, ankle fracture complexity, and the need for open reduction and fixation of the syndesmosis.

A retrospective analysis of the NSQIP database was performed for patients undergoing surgical fixation of isolated, closed ankle fractures. Patients were grouped by fracture pattern into 6 cohorts (uni-, bi- and trimalleolar ankle fractures with or without syndesmotic injury). Demographic data was collected and compared between groups and logistic regression analyses were used to assess the relationship between body mass index (BMI) and ankle fracture pattern.

A total of 15,841 patients (mean age 48.9 years) were identified for inclusion. Regression analyses revealed that BMI had a significant association with the incidence of open reduction and internal fixation of the ankle syndesmosis, but there was no association between BMI and malleolar fracture pattern.

This study demonstrates that elevated BMI is associated with an increased risk for open reduction and internal fixation of the syndesmosis in malleolar ankle fractures. read more However, obesity was not associated with ankle fracture pattern itself, whereas older age, female sex, and white race were more significant predictors of fracture complexity. This data provides a framework for further evaluation of the effect that both modifiable and non-modifiable risk factors have on fracture complexity and operative management of patients with such injuries.

Case-control study. Level III.

Case-control study. Level III.Although the reported clinical outcomes of total hip arthroplasty (THA) for hip osteoarthritis are satisfactory, not all patients are completely satisfied. Thus, there is interest in predicting postoperative satisfaction before surgery. The influence of comorbidities and preoperative medications on the incidence of complications and duration of hospitalization following THA has become apparent. However, studies about the associations of preoperative medication with clinical outcomes of THA are limited. Therefore, this study aimed to clarify the relationship between preoperative medications and postoperative patient-reported outcomes. This retrospective cross-sectional multicenter study enrolled post-THA patients (79 patients, 90 hips) who were examined from February to March 2019 in eight general hospitals. Outcome measures included patient-reported outcome as Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) score. Preoperative medications were investigated from medical records. Medications were categorized, and analgesics were categorized into non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen, pregabalin, duloxetine, neurotropin (an extract from inflammatory rabbit skin inoculated by vaccinia virus), and opioid.