Activity

To evaluate whether or not embryo transfer day has an effect on the rates of clinical pregnancy (CPR) and live birth (LBR) in in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) treatment.

A total of 757 patients who had undergone IVF-ICSI treatment between 2012 and 2017 were included in this study. The participants were stratified according to embryo transfer day as Group 1 (day 2 transfer; n= 43), Group 2 (day 3 transfer; n=633), and Group 3 (day 5 (blastocyst) transfer; n=81). Basal parameters and IVF-ICSI outcomes were compared between the groups.

Groups 1 and 2 patients were older, had a higher BMI, worse responder rate, lower antral follicle count, lower peak E2 levels, and less endometrial thickness, and required an increased total gonadotropin dose than the other transfer day groups. In addition, the number of oocytes and MII oocytes, fertilization rate, and 2 PN were statistically different between the groups and the CPR (19.5% vs 36.9% vs 39.0%, respectively) and LBR (14.6% vs 30.4% vs 35.1%, respectively) were lower in group 1 than groups 2 and 3 (p<0.05). The grade I embryos were significantly higher in groups 1 and 2 with clinical pregnancy positive (OR=4.444; 95% CI 0.876-22.536; p=0.001 and OR=1.756; 95% CI 1.234-2.500; p<0.001) and live birth (OR=5.021; 95% CI 0.787-31.768; p=0.001 and OR=1.676; 95% CI 1.154-2.433; p=0.007).

The data suggest that an earlier embryo transfer day has a negative effect on the clinical pregnancy rate. Older primary infertile women should not postpone their desire to have a baby because they are poor responders, and it should be explained that the chances of successful treatment are lower.

The data suggest that an earlier embryo transfer day has a negative effect on the clinical pregnancy rate. Older primary infertile women should not postpone their desire to have a baby because they are poor responders, and it should be explained that the chances of successful treatment are lower.Volume kinetics is the pharmacokinetics of infusion fluids and describes the distribution and elimination of infused volume. NSC 364372 Generally, pharmacokinetic parameters can be estimated by measuring the concentration of a drug. However, it is almost impossible to directly measure the concentration of fluids. Therefore, in volume kinetics, the disposition of fluids is indirectly quantified by measuring the hemoglobin concentration under the premise of no hemoglobin loss. If the hemoglobin concentration is repeatedly measured while administering the fluids, the dilution (relative change of the plasma volume) for each corresponding hemoglobin concentration can be obtained. The dilution is based on the concept of plasma volume expansion. The method of quantifying the drugs disposition with compartmental analysis has been equally applied to volume kinetics. The transfer of fluids between compartments is explained by first-order kinetics, and it is assumed that fluid is only removed from the central compartment. Population analysis can be used to identify covariates that can account for inter-individual variability in volume kinetic parameters. Body weight and mean blood pressure are well-known representative covariates of kinetic volume parameters. Using volume kinetic parameters, the volume expansion effects of crystalloid and colloid solutions can be understood more effectively, thereby facilitating appropriate fluid therapy. Although limitations exist in volume kinetics, its implications are important for clinicians when administering fluids.Gestation weight (GW), body mass index (BMI), and the blood 25-hydroxyvitamin D (25(OH)D) level during pregnancy are important determinants of the gestational outcomes. This study aims to study how these parameters vary between antenatal vitamin D recipients and non-recipients in gestational diabetes mellitus (GDM) patients. The randomized controlled trials comparing these outcomes between vitamin D recipient and non-recipient GDM patients were searched in electronic databases (PubMed, Embase, and Scopus). The reviewed studies’ data were abstracted and critically appraised by the Cochrane tool. The estimation of the weighted mean difference for GW and BMI and standardized mean difference (SMD) for 25(OH)D levels occurred by juxtaposing the interventions meta-analytically (random-effect model). The statistical inconsistency was determined by Chi2 and I2 method. The statistical significance was estimated at p less then 0.05 and 95% confidence interval (CI). Eleven eligible trials (all Iran-based, except one) sourcing data from about 875 GDM patients were reviewed. Overall, the risk of bias was low, except for selection and performance bias. On random-effect model meta-analysis, the 25(OH)D levels of the GDM patients favored the vitamin D recipients when compared to non-vitamin D (SMD 1.97, 95%CI, 1.06, 2.88, p, less then 0.001, I2, 96.2%, p of Chi2, less then 0.001) and placebo (SMD, 1.86, 95% CI, 0.95, 2.77, p, less then 0.001, I2, 95.3%, p of Chi2, less then 0.001) recipients, respectively. On meta-regression, sample size was a predictor of the observed heterogeneity. For GW and BMI the interventions did not differ statistically significantly. In GDM patients, antenatal use of vitamin D aids in the rise of blood 25(OH)D levels; however, it doesn’t influence GW and BMI change. PROSPERO registration number CRD42020149613.

This meta-analysis aimed to compare the effect of laparoscopic supracervical hysterectomy (LSH) with endometrial ablation (EA) in terms of general and menstrual-related quality of life in women opting for surgical treatment for abnormal uterine bleeding.

Sources searched included PubMed, Cochrane library, Scopus, and Web of Science for relevant clinical trials. Main outcomes of interest included quality of life assessed using medical outcomes survey short form-36 (SF-36), (SF-12), operation time, time from operation to discharge, pain, fever, and hemoglobin level. Screening and data extraction were performed independently and the analysis was conducted using Review Manager Software v5.4.1.

Four clinical trials were included. Results of SF-12 score showed that there was no significant difference between the LSH and EA groups for either mental or physical component score overall mean difference (MD) -4.15 (-16.01, 7.71; p=0.49) and MD 2.67 (-0.37, 5.71; p=0.08), respectively. Subgroup analysis of the SF-36 showed that only two components, general health and social function, were significantly improved in the LSH group (p<0.