Activity

This AOP (i.e. AOP1) consists of the following key events cytochrome oxidase inhibition (>10 ppm), neuronal cell loss (>30 ppm), and olfactory nasal lesions (defined as both neuronal cell loss and basal cell hyperplasia; >30 ppm) in rodents. The key event relationships in this pathway were supported by moderate empirical evidence and have high biological plausibility due to known mechanistic understanding and consistency in observations for diverse chemicals.A vegan diet is associated with reduced cardiovascular morbidity and mortality, but protein deficiencies may be detrimental to skeletal muscle structure and function. The aim of this study was to compare the vascular and skeletal muscle properties between young, healthy, recreationally active habitual vegan (VEG) and omnivorous (OMN) men. Sixteen OMN and nine VEG underwent ultrasound scans to determine brachial artery flow-mediated dilation (FMD) and carotid artery intima-media thickness (cIMT) and vastus lateralis (VL) muscle thickness and fascicle pennation angle. Knee extension maximal voluntary isometric contraction (MVIC) force was assessed on an isokinetic dynamometer, and V˙O2max on a cycle ergometer and online gas analysis system. A three-day food diary determined habitual dietary behaviour. Bayesian analyses of independent groups provided “moderate” to “very strong” evidence for lower consumption of absolute (63±21 g/d vs. 98 ± 30 g/d; Bayes Factor (BF01) = 0.140) and relative (0.86 ± 0.29 g/kg/d vs.1.36 ± 0.52 g/kg/d; BF01 = 0.259) protein, absolute saturated fat (15.2 ± 7.9 g vs. 30.3 ± 11.8 g; BF01 = 0.089) and cholesterol (5.0 ± 6.0 mg vs. 337.9 ± 232.6 mg; BF01 = 0.019) in VEG compared to OMN, respectively. Further, there was “anecdotal” evidence to support no differences in FMD (3.37 ± 3.31% vs. 4.58 ± 5.82%; BF01 = 2.591), cIMT (0.51 ± 0.07 mm vs. 0.49 ± 0.04 mm; BF01 = 2.510), VL thickness (26.1 ± 3.7 mm vs. 27.8 ± 6.4 mm; BF01 = 2.726), fascicle pennation angle (16.6 ± 4.7° vs. 17.7 ± 3.7°; BF01 = 2.844), MVIC (627 ± 182 N vs. 551 ± 102 N; BF01 = 1.656) or V˙O2max (40.8 ± 9.8 ml/kg/min vs. 35.8 ± 5.2 ml/kg/min; BF01 = 1.218) between VEG and OMN, respectively. Despite marked differences in habitual nutrient intake, healthy, young vegan and omnivorous men did not differ regarding vascular and skeletal muscle structure and function, or cardiovascular fitness.

To determine the effect of a single session of arm crank ergometry (ACE) exercise on carbohydrate metabolism immediately and 24 h after the exercise bout in paraplegia and able-bodied controls (ABC).

Paraplegia (

 = 11; 91% male; age 34.8 ± 11.4 years) and ABC (

 = 6; 67% male; age 28.7 ± 11.9 years) underwent 45 min of ACE exercise at 75% VO

. Glucose effectiveness (Sg) and insulin sensitivity (Si) were assessed. Data were analyzed with two-way mixed analysis of variance and Wilcoxon rank-sum or signed-rank

test.

VO

was lower in paraplegia versus ABC (22.3 ± 3.99 vs. 30.8 ± 2.9 ml/kg/min,

 = 0.003). Si was lower paraplegia vs. ABC immediately following exercise (3.28 ± 1.6 vs. 5.30 ± 1.2 min

/[µU/mL

]x10

,

 = 0.023). In paraplegia, Sg was higher immediately after exercise than baseline (B 0.021 ± 0.01 vs. I 0.026 ± 0.01 min

,

 = 0.037). Twenty-four hours after exercise, Sg was lower than immediately following exercise (I 0.026 ± 0.01 vs. 24 0.017 ± 0.01 min

,

 = 0.001), but not difed past 24-hours. These data provide support for regular exercise engagement.Implications for RehabilitationDisorders of glucose metabolism have been reported at a greater prevalence in persons with spinal cord injury.A single bout of arm crank ergometry exercise at 75% VO2Peak helped to acutely control glucose metabolism persons with paraplegia; however, this was not sustained past 24 h.These data provide support for regular exercise engagement in persons with paraplegia.Introduction Urothelial carcinoma (UC) is the second most common malignancy of the genitourinary system in the US, but mortality rate has not significantly improved despite advances in therapy. Over the past few years, the treatment landscape of non-muscle-invasive, muscle-invasive and metastatic UC (mUC) has evolved with the advent of immunotherapy.Areas covered This paper summarizes current data and ongoing research into the use of immune checkpoint inhibitors (ICIs) in various settings of UC, including as maintenance therapy in chemotherapy-responsive mUC (with recent approval for avelumab in this setting) and as neoadjuvant and adjuvant therapies in localized and non-muscle-invasive disease. In addition, the authors review the combination of ICIs with chemotherapy, radiation and targeted therapies in an effort to increase response durability and efficacy.Expert opinion While there has been a rapid expansion in clinical trials, platinum-based chemotherapy remains standard treatment in perioperative and first-line metastatic UC. this website The identification of biomarkers that can identify patients who will respond to ICIs has yielded conflicting results and has been largely non-generalizable to clinical practice. Further research into novel strategies and combinations with ICIs is needed to better characterize the role of immunotherapy in UC.

To explore the perspectives of general practitioners (GPs) on facilitators and barriers in diagnosing rheumatoid arthritis (RA).

Qualitative study based on focus group interviews, and using latent thematic analysis.

General practices from Central Region Denmark.

Eleven GPs participated in three different focus groups. Forty percent were female, the mean age was 53 years (range 37-64), and the mean since medical licensing was 16 years (range 5-23). Sixty percent of the GPs worked in an area served by a university hospital, and 40% were served by a regional hospital.

Themes describing experiences and reflections about facilitators and barriers in diagnosing Rheumatoid Arthritis.

Four themes emerged (A) If the patient is not a textbook example, (B) The importance of maintaining the gatekeeper function, (C) Difficulties in referral of patients to the rheumatologist, and (D) Laboratory tests-can they be trusted? Barriers were identified in all themes, but facilitators only in A, C, and D. The overarching theme was

.