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The proposed parameter comes in the form of a range of values, whose limits are δRA/(12)1/2 and δRA/(3)1/2, with δRA being defined as the difference between the maximum and minimum values of the analyte concentration that would be predicted by the MCR model from its concentration profiles lying in the range of feasible solutions, and corresponding to maximum and minimum area respectively. We support our proposal on extensive simulations for systems of varying composition, and demonstrate its application on experimental data aimed at the determination of four pollutants in environmental water samples.The exquisite combination of independent 3p [In(CO2)4] units and 4f [Tb2(CO2)8] clusters in the presence of the designed hexatopic 2,4,6-tri(2,4-dicarboxyphenyl)pyridine ligand engenders one peculiar nanocaged In(III)Tb(III)2-organic framework ((Me2NH2)[InTb2(HTDP)2]·3DMF·3H2On, designated as NUC-5), which features dual types of lotus-shaped channels along the [100] and [110] axes with related node windows of 5.3 × 6.8 and 12.1 × 9.2 Å2, respectively. PCI32765 To the best of our knowledge, except several coexisted 3p-4f In/Ln clusters of In3Ln- and In3Ln2-based metal-organic frameworks (MOFs), NUC-5 is one novel type of In/Ln heterometallic framework. In addition, its topology was an unprecedented 3D TAYZIC net with a Schläfli symbol of 4.4624.56524.66.88. Moreover, activated NUC-5 is proved to be one efficient adsorbent for CO2 and one recycled cycloaddition catalyst for the transformation of epoxides into related carbonates with high yields under mild conditions. Furthermore, the excellent reversible sorption performance for I2 in the volatilization phase or in cyclohexane solution with a maximum adsorption capacity of 609.1 mg/g (3.75 iodine molecules per unit cell) makes NUC-5 a promising adsorbent for radioactive products of 129I and 131I in the field of nuclear industry. This study provides one synthetic strategy that the original nature of MOFs could be enhanced by introducing some specific function-prompted inorganic subunits with the aid of predesigned supporting ligands.Lysophosphatidylserine (lyso-PS), a lysophospholipid derived from phosphatidylserine (PS), has emerged as a potent signaling lipid in mammalian physiology. In vivo, the metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade lyso-PS, respectively. Of biomedical relevance, deleterious mutations to ABHD12 cause accumulation of lyso-PS in the brain, and this deregulated lyso-PS metabolism leads to the human genetic neurological disorder PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract). While the roles of ABHD16A and ABHD12 in lyso-PS metabolism in the mammalian brain are well established, the anatomical and (sub)cellular localizations of both lipases and the functional cross-talk between them with respect to regulating lyso-PS lipids remain under investigated. Here, using subcellular organelle fractionation, biochemical assays, and immunofluorescence-based high-resolution microscopy, we show that the PS lipase ABHD16A is an endoplasmic reticulum-localized enzyme, an organelle intricately regulating cellular PS levels. In addition, leveraging immunohistochemical analysis using genetic ABHD16A and ABHD12 knockout mice as important controls, we map the anatomical distribution of both of these lipases in tandem in the murine brain and show for the first time the distinct localization of these lipases to different regions and cells of the cerebellum. We complement the aforementioned immunohistochemical studies by quantitatively measuring lyso-PS concentrations in various brain regions using mass spectrometry and find that the cerebellar lyso-PS levels are most affected by deletion of ABHD16A (decreased) or ABHD12 (increased). Taken together, our studies provide new insights into lyso-PS signaling in the cerebellum, the most atrophic brain region in human PHARC subjects.Herein, we report the discovery of a series of JAK1-selective kinase inhibitors with high potency and excellent JAK family subtype selectivity. A fragment screening hit 1 with a pyrazolopyridone core and a JAK1 bias was selected as the starting point for our fragment-based lead generation efforts. A two-stage strategy was chosen with the dual aims of improving potency and JAK1 selectivity Optimization of the lipophilic ribose pocket-targeting substituent was followed by the introduction of a variety of P-loop-targeting functional groups. Combining the best moieties from both stages of the optimization afforded compound 40, which showed excellent potency and selectivity. Metabolism studies in vitro and in vivo together with an in vitro safety evaluation suggest that 40 may be a viable lead compound for the development of highly subtype-selective JAK1 inhibitors.A large linear negative thermal expansion (NTE) and expanded NTE temperature range (ΔTNTE) were obtained in magnetoelastic CrTe1-xSex (0 ≤ x ≤ 0.15) compounds. For CrTe compound, its thermal expansion coefficient of volume (αV) was calculated to be -28.8 ppm K-1 with the temperature ranging from 280 to 340 K. Substituting Te with Se atoms, the NTE behavior and magnetic properties can be well manipulated. With increasing Se in CrTe1-xSex (0 ≤ x ≤ 0.15) compounds, the ΔTNTE increases from 60 K (280-340 K for x = 0), to 80 K (240-320 K for x = 0.05), to 95 K (200-295 K for x = 0.1), and finally to 100 K (170-270 K for x = 0.15). Furthermore, a linear NTE remains independent of temperature for samples with x ≤ 0.1. The relationship between tunable NTE and magnetic properties was analyzed in detail, indicating that the NTE in CrTe1-xSex compounds originates from the magnetovolume effect (MVE).Supramolecular frameworks driven by intermolecular interactions represent a new type of porous materials differing from those driven by covalent or coordination bonding. The intermolecular interaction-induced flexible assembly structures display unique advantages in material processing, structure stimuli response, and recycling. In this work, a two-dimensional (2D) supramolecular ionic framework (SIF) was constructed through the initial ionic interaction between the host cation and polyoxometalate polyanion and then the host-guest inclusion of the formed host ionic complex with a four-arm porphyrin guest molecule following a [2+4] type reaction. Several prepared framework monolayers bearing an orthometric grid structure constituted a nanosheet-like assembly with flexibility and exhibited processability, which provided feasibility for the further preparation of separation membranes via a simple suction procedure of their dispersed suspensions in mixed solvents. The nanofiltration based on the uniform square pores under a slightly reduced pressure successfully achieved precise separation of several types of nanoparticles and molecular clusters in wide distribution at a cutting off value as small as 2.