Activity

ant preference but generally preferred handover to take place away from the bedside, all else equal. When implementing bedside handover in a Swedish context this must be considered, although participation is a prerequisite for bedside handover. Differences between patients and nurses’ preferences could jeopardize future introduction of bedside handover in Swedish health care, and might explain why bedside handover is still not very common in hospital wards. BACKGROUND Nursing work has indisputable relational characteristics, however there is scarce research that examines nurses’ work and wellbeing using a relational job design framework. AIM The aim is to study the relationships between job characteristics and nurses’ work-related wellbeing. More specifically, this study focuses on the unique contribution of psychological effects of relational job characteristics to nurses’ work engagement and burnout, beyond the effects of other job characteristics commonly studied in association with wellbeing, namely quantitative job demands and control. DESIGN AND PARTICIPANTS Cross-sectional research design, in which 409 Portuguese hospital registered nurses participated. METHOD Data were collected using an online survey. Statistical procedures included structural equation modelling and multiple regression analysis. RESULTS Data suggest that perceived social impact and perceived social worth are related to nurses’ work engagement and burnout beyond the effects of quantitative job demands and control. CONCLUSIONS The study of the relationships between psychological effects of relational job characteristics and work-related outcomes (such as nurse work-related wellbeing) is relevant, as these relational job design variables explain variance in these outcome variables, beyond other job design constructs (specifically job demands and control). IMPLICATIONS Theoretical implications include the value of studying the impact of psychological effects of relational job characteristics on wellbeing outcomes among nurses. As for practical implications, hospitals may address relational job characteristics in order to increase their nurses’ perceptions of their job’s impact and the social worth attributed to their work, which is positively related to work engagement and negatively related to burnout. BACKGROUND Women differ from men in their left ventricular (LV) structure, function, and remodeling with age and diseases. The LV assist device (LVAD) unloads the LV and reversely remodels the heart. We sought to define the effects of sex on longitudinal reverse remodeling after LVAD implantation. SAR439859 METHODS Cardiac structure and function were assessed by serial echocardiograms. Mixed effect regression models were constructed to assess the independent contribution of sex to longitudinal changes in cardiac structure and function. RESULTS A total of 355 consecutive patients with advanced heart failure (HF) received continuous flow LVADs between 2006 and 2016. The average age was 56±13 years, 73% were men and 67% were black. Early (within 3 months) after LVAD implantation, women had a greater reduction in LV dimensions and a greater increase in LV ejection fraction compared with men. These differences were independent of age, BSA, device type or ischemic etiology of HF. At long-term follow-up, LV dimensions increased slightly over time in women compared with men, but overall earlier changes were maintained. CONCLUSION Women had significantly more favorable longitudinal changes in cardiac structure and function in response to LV unloading compared with men. Understanding the cause of sex difference in reverse remodeling after LVAD may help devise novel therapeutic strategies for women with advanced HF. Lanthanide-doped nanoparticles (LnNPs) have gained increasing attention recently for bioimaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) because of their excellent photophysical properties, but the construction of LnNPs-based activable probe responding to specific targets remains a challenge. Herein, we proposed an uncomplicated and universal strategy to fabricate LnNPs-based NIR-II probes by target-triggered dye-sensitization process. The dye acts as both the recognition motif of the target and a potential antenna for LnNPs, which can be activated by the target to sensitize the NIR-II luminescence of LnNPs. A proof-of-concept probe for glutathione (GSH) was constructed to validate this approach. It was able to track the fluctuation of GSH level in liver and lymphatic drainage and provide clear images with high contrast and resolution in vivo. This strategy can be generalized to construct NIR-II probes for various analytes by simply changing the recognition motif of the dye, greatly promoting the application of LnNPs. In 1982, an oxo-bridged dinuclear ruthenium(III) complex, known as “blue dimer,” was discovered to be active for water oxidation. In this work, a new amphiphilic ruthenium “green dimer” 2, obtained from an amphiphilic mononuclear Ru(bda) (N-OTEG) (L1) (1; N-OTEG = 4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-pyridine; L1 = vinylpyridine) is reported. An array of mechanistic studies identifies “green dimer” 2 as a mixed valence of RuII-O-RuIII oxo-bridged structure. Bearing the same bda2- and amphiphilic axial ligands, monomer 1 and green dimer 2 can be reversibly converted by ascorbic acid and oxygen, respectively, in aqueous solution. More importantly, the oxo-bridged “green dimer” 2 was found to take water nucleophilic attack for oxygen evolution, in contrast to monomer 1 via radical coupling pathway for O-O bond formation. This is the first report of an amphiphilic oxo-bridged catalyst, which possesses a new oxygen evolution pathway of Ru-bda catalysts. The UGA codon signals protein translation termination, but it can also be translated into selenocysteine (Sec, U) to produce selenocysteine-containing proteins (selenoproteins) by dedicated machinery. As Sec incorporation can fail, Sec-containing longer and Sec-lacking shorter proteins co-exist. Cul2-type ubiquitin ligases were recently shown to destabilize such truncated proteins; however, which ubiquitin ligase targets truncated proteins for degradation remained unclear. We report that the Cul5-type ubiquitin ligase KLHDC1 targets truncated SELENOS, a selenoprotein, for proteasomal degradation. SELENOS is involved in endoplasmic reticulum (ER)-associated degradation, which is linked to reactive oxygen species (ROS) production, and the knockdown of KLHDC1 in U2OS cells decreased ER stress-induced cell death. Knockdown of SELENOS increased the cell population with lower ROS levels. Our findings reveal that, in addition to Cul2-type ubiquitin ligases, KLHDC1 is involved in the elimination of truncated oxidoreductase-inactive SELENOS, which would be crucial for maintaining ROS levels and preventing cancer development.