Activity

to help reduce the late toxicity risk.

3500 cm3) to recommend for practitioners to help reduce the late toxicity risk.

Electrosurgery smoke is the smoke emitted from tissue cauterization when using the electrosurgery device. click here Accordingly, in this smoke, more than 80 harmful toxins have been discovered. In the current study, we aimed to investigate the level of knowledge reported by the operating room nurses on the effects of electrosurgery smoke during the current COVID-19 pandemic.

This descriptive, survey-based cross-sectional study was performed on 533 OR nurses in all the referring hospitals of COVID-19 infection. The required information were collected using a questionnaire regarding the knowledge on the side effects of electrosurgery smoke. The obtained data were then analyzed using

-test and ANOVA by SPSS software.

Most of the included participants (93.6%) had a low level of awareness and only a small number of them (0.4%) had a good level of knowledge on the effects of electrosurgery smoke. As well, a significant relationship (P˂0.05) was found between the level of knowledge reported by the OR nurses and the type of hospital (educational or private). Most of the studied hospitals used no electrosurgery smoke reduction equipment during electrosurgery.

The level of knowledge reported by the OR nurses was generally poor. It is recommended that managers and health officials try to increase the level of awareness of OR nurses during the COVID-19 pandemic by providing standard and protective equipment as well as holding some well-organized and related training courses.

The level of knowledge reported by the OR nurses was generally poor. It is recommended that managers and health officials try to increase the level of awareness of OR nurses during the COVID-19 pandemic by providing standard and protective equipment as well as holding some well-organized and related training courses.The study investigated the antioxidant effect of Ruzu herbal bitters (RHB) on alloxan-induced diabetic rats, the pH and the bioactive components of RHB using gas chromatography and mass spectroscopy (GC-MS). Fifty-four adult albino rats were divided into nine groups of six rats each. Group 1 was the normal control. Groups 2-6 were diabetic. Group 2 was untreated positive control, while groups 3-6 were respectively treated with 5 mg/kg b. w of glibenclamide, 0.14, 0.29 and 0.57 ml/kg b. w of RHB for 21 days. Groups 7-9 were not diabetic but treated as in groups 4-6 respectively. The results showed significant (p less then 0.05) increase in the blood glucose level and significant (p less then 0.05) decrease in weight in diabetic untreated group compared to the normal control. The oxidative stress parameters showed significant (p less then 0.05) increases in the serum activities of superoxide dismutase (SOD) and catalase (CAT), with significant (p less then 0.05) decrease in glutathione peroxidase (GPx); while there were significant (p less then 0.05) increases in the levels of vitamin C (VIT C), vitamin E (VIT E), C-reactive protein (CRP) and malondialdehyde (MDA), with significant (p less then 0.05) decrease in the level of glutathione (GSH) in the diabetic untreated group compared to the normal control group. However, treatment of the diabetic groups with different doses of RHB resulted in the reversal of the effects to near-normal levels in a dose-dependent manner. The pH of RHB was found to be 3.45. The GC-MS result of RHB revealed the presence of 10 bioactive compounds, out of which four are pharmacologically important antioxidants 11-Octadecenioc acid -Methyl esther, 2,7-Dioxatricyclodeca-4, 9-diene, Cis-Z-α- Bisabolene epoxide, and Tetradecanoic acid (lauric acid). Thus, the study revealed that Ruzu herbal bitters possesses antidiabetic and antioxidant activities due to the bioactive antioxidant compounds it contains.Gastric carcinoma (GC) is one of the most common malignancies and the third leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) may be an important class of functional regulators involved in human gastric cancers development. In this study, we investigated the clinical significance and function of lncRNA SNHG1 in GC. SNHG1 was significantly downregulated in GC tumor tissues compared with adjacent noncancerous tissues. Overexpression of SNHG1 in BGC-823 cells remarkably inhibited not only cell proliferation, migration, invasion in vitro, but also tumorigenesis and lung metastasis in the chick embryo chorioallantoic membrane (CAM) assay in vivo. Conversely, inhibition of SNHG1 by transfection of siRNA in AGS cells resulted in opposite phenotype changes. Mechanically, SNHG1 was found interacted with ILF3, NONO and SFPQ. RNA-seq combined with bioinformatic analysis identified a serial of downstream genes of SNHG1, including SOCS2, LOXL2, LTBP3, LTBP4. Overexpression of SNHG1 induced SOCS2 expression whereas knockdown of SNHG1 decreased SOCS2 expression. In addition, knockdown of SNHG1 promoted the activation of JAK2/STAT signaling pathway. Taken together, our data suggested that SNHG1 suppressed aggressive phenotype of GC cells and regulated SOCS2/JAK2/STAT pathway.Bacterial infections are a major cause of chronic infections and mortality. Innate immune control is crucial for protection against bacterial pathogens. Bile acids facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5). Here, we identified a new role of FXR and TGR5 in promoting inflammasome activation during bacterial infection. Caspase-1/11 activation and release of cleaved interleukin (IL)-1β in FXR- and TGR5-deficient mouse bone marrow-derived macrophages upon Listeria monocytogenes or Escherichia coli infection was significantly reduced. In contrast, FXR- or TGR5-deficiency did not affect the transcription of caspase-1/11 and IL-1β. Inflammasome activation is critical for host immune defense against bacterial infections. Consistent with this, the deletion of FXR or TGR5 impaired effective clearance of L. monocytogenes or E. coli in vitro and in vivo, which was associated with greater mortality and bacterial burden than that of wild-type mice.