Activity

The expressions of StAR, TSPO, CYP11A1, HSD3B7, HSD17B4 and SF-1 in the Leydig cells were significantly decreased in the LOH model controls compared with those in the normal controls (P< 0.05), but remarkably increased in the low-, medium- and high-dose XYP groups in comparison with those in the LOH model control group (P< 0.05).

Xiongcan Yishen Prescription can up-regulate the expressions of the cholesterol transport proteins StAR and TSPO, steroidogenic enzymes CYP11A1, HSD3B7 and HSD17B4, and SF-1 in the rat Leydig cells, which might be one of the possible mechanisms of the prescription in the treatment of LOH.

Xiongcan Yishen Prescription can up-regulate the expressions of the cholesterol transport proteins StAR and TSPO, steroidogenic enzymes CYP11A1, HSD3B7 and HSD17B4, and SF-1 in the rat Leydig cells, which might be one of the possible mechanisms of the prescription in the treatment of LOH.

To investigate the distribution of pathogenic bacteria in donor semen and the effect of bacterial infection on semen quality.

We performed bacterial culture on and counted the bacterial colonies (BC) in the semen samples collected from 4 897 sperm donors from 2008 to 2018 and divided them into groups A (BC <104 cfu/ml, n = 4 229), B (BC ≥104 cfu/ml, n = 150) and C (BC = 0 cfu/ml, n = 518). Using the biochemical reaction system of the French Biological Merry Emmanuel Company, we identified the bacterial species in group B, subjected all the semen samples to SCA computer assisted semen analysis, and compared the semen quality among different groups.

In the 4 897 semen samples, hybrid bacterial contamination was found in 6 (0.12%) and non-hybrid bacteria in 4 379 (89.42%), including 150 (3.43%) in group B. In the semen samples with BC ≥104 cfu/ml, Gram-negative (G－) bacteria were observed in 104 (69.33%), mainly including Escherichia coli, followed by Proteusbacillus vulgaris and Enterobacteria, Gram-positive cocci (G+) in 39 (26.00%), G－ bacteria in 4 (2.67%) and Neisseria gonorrhoeae in 3 (2.00%). Compared with group C, groups A and B showed remarkably reduced total sperm count (P < 0.05) and percentage of progressively motile sperm (P < 0.05) but no statistically significant differences in the semen liquefaction time, semen PH value, total sperm motility or the percentage of morphologically normal sperm (P > 0.05).

Bacterial culture of donor semen revealed a positive rate of 89.42% and varied the bacterial species, mainly including G－ bacteria. And the semen quality decreased with the increase of bacterial colonies.

Bacterial culture of donor semen revealed a positive rate of 89.42% and varied the bacterial species, mainly including G－ bacteria. learn more And the semen quality decreased with the increase of bacterial colonies.

To find the causes of the failure in the first catheter removal (CR) after transurethral resection of the prostate (TURP) and the related risk factors.

We collected the clinical data on 285 BPH patients treated by TURP from June 2015 to May 2018. We divided the cases into a successful CR (SCR) and a failed CR (FCR) group and investigated the risk factors for the first CR after TURP by multivariate logistic regression analysis.

CR was successfully performed in 246 and failed in 39 of the 285 cases. In the FCR group, post-CR urinary retention occurred in 15 cases immediately after, severe urinary tract irritation in 13, massive gross hematuria in 7 and urinary incontinence in 4 within 1 month. Multivariate logistic regression analysis showed that the independent risk factors for CR failure included IPSS (OR = 5.106, P = 0.013), preoperative urinary tract infection (OR = 3.835, P = 0.041), prostate volume (OR = 4.160, P = 0.011) and catheter compression time (OR = 4.051, P = 0.017).

The common causes of the failure in catheter removal after TURP included early postoperative urinary retention, urinary infection, secondary hematuria and urinary incontinence.

The common causes of the failure in catheter removal after TURP included early postoperative urinary retention, urinary infection, secondary hematuria and urinary incontinence.

To compare the clinical effect and safety of monoplane holmium laser enucleation of the prostate (MP-HoLEP) from those of biplane HoLEP (BP-HoLEP) in the treatment of large-volume BPH.

We retrospectively analyzed the clinical data on 67 cases of large-volume BPH treated in Jintan People’s Hospital from June 2017 to December 2018, 30 by MP-HoLEP with incisions at 5- and 7-o’clock positions beside the verumontanum and the other 37 by BP-HoLEP with incision at 12 o’clock in the bladder neck to expose the surgical capsule layer. We compared the perioperative, postoperative and follow-up data between the two groups of patients.

There were no statistically significant differences between the two groups of patients in the age, disease course, prostate volume or preoperative post-void residual urine volume (PVR), maximum urine flow rate (Qmax), IPSS, PSA level and quality of life score (QOL). Compared with the patients in the MP-HoLEP group, those treated by BP-HoLEP showed a significantly shorter operation time (［97.65 ± 34.72］ vs ［125.46 ± 47.58］ min, P < 0.01) and tissue-enucleation time (［60.34 ± 23.45］ vs ［97.43 ± 35.51］ min, P < 0.01) and lower intraoperative level of hemoglobin (［14.58 ± 1.11］ vs ［21.44 ± 1.28］ g, P < 0.01). Statistically significant differences were not observed in the intraoperative adverse events, volume of the resected tissue, time of bladder irrigation or length of postoperative hospital stay, nor in the incidence of transient urinary incontinence (33% vs36.8%, P > 0.05). PVR, Qmax, IPSS and QOL were improved similarly in both of the groups at 6 months postoperatively.

Both MP-HoLEP and BP-HoLEP are definitely effective for the treated of large-volume BPH, but the latter is superior to the former for shorter operation and enucleation time and less bleeding.

Both MP-HoLEP and BP-HoLEP are definitely effective for the treated of large-volume BPH, but the latter is superior to the former for shorter operation and enucleation time and less bleeding.