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Three patients had postoperative complications not related to the induction therapy. All patients had a pathological response 5 complete, 4 major and 3 partial. Eleven patients are alive (mean months of follow-up 18.17±4.97) and free of disease.

Induction ICI-chemotherapy may be a valid treatment in patients with locally advanced NSCLC, providing important tumor downstaging and rendering patients operable. In our experience patients had few side effects and a good pathological response.

Induction ICI-chemotherapy may be a valid treatment in patients with locally advanced NSCLC, providing important tumor downstaging and rendering patients operable. In our experience patients had few side effects and a good pathological response.

Clear cell soft-tissue sarcoma is a rare tumor typically presenting in the lower extremities.

We present a middle-aged woman with a 2-month history of a growing mass in the right hand dorsum. Initial biopsy reported findings consistent with benign fibroma, however, high-resolution ultrasound screening revealed a multilobulated, heterogeneous, and hypervascular mass highly suspicious for malignancy. Excisional biopsy, histology, and immunohistochemistry confirmed the diagnosis of clear-cell soft tissue sarcoma. The patient presented no evidence of recurrence at 6-month follow-up.

Ultrasound is an accessible and cost-effective modality for screening and management guidance for soft-tissue sarcomas.

Ultrasound is an accessible and cost-effective modality for screening and management guidance for soft-tissue sarcomas.Chronic exposure to opioids typically results in adverse consequences. Opioid use disorder (OUD) is a disease of the CNS with behavioral, psychological, neurobiological, and medical manifestations. OUD induces a variety of changes of neurotransmitters/neuropeptides in the nervous system. Existing pharmacotherapy, such as opioid maintenance therapy (OMT) is the mainstay for the treatment of OUD, however, current opioid replacement therapy is far from effective for the majority of patients. Pharmacological therapy for OUD has been challenging for many reasons including debilitating side-effects. Therefore, developing an effective, non-pharmacological approach would be a critical advancement in improving and expanding treatment for OUD. Viral vector mediated gene therapy provides a potential new approach for treating opioid abused patients. Gene therapy can supply targeting gene products directly linked to the mechanisms of OUD to restore neurotransmitter and/or neuropeptides imbalance, and avoid the off-target effects of systemic administration of drugs. The most commonly used viral vectors in rodent studies of treatment of opioid-used disorder are based on recombinant adenovirus (AV), adeno-associated virus (AAV), lentiviral (LV) vectors, and herpes simplex virus (HSV) vectors. In this review, we will focus on the recent progress of viral vector mediated gene therapy in OUD, especially morphine tolerance and withdrawal.This review explores forms of respiratory and autonomic plasticity, and associated outcome measures, that are initiated by exposure to intermittent hypoxia. The review focuses primarily on studies that have been completed in humans and primarily explores the impact of mild intermittent hypoxia on outcome measures. Studies that have explored two forms of respiratory plasticity, progressive augmentation of the hypoxic ventilatory response and long-term facilitation of ventilation and upper airway muscle activity, are initially reviewed. The role these forms of plasticity might have in sleep disordered breathing are also explored. Thereafter, the role of intermittent hypoxia in the initiation of autonomic plasticity is reviewed and the role this form of plasticity has in cardiovascular and hemodynamic responses during and following intermittent hypoxia is addressed. The role of these responses in individuals with sleep disordered breathing and spinal cord injury are subsequently addressed. Ultimately an integrated picture of the respiratory, autonomic and cardiovascular responses to intermittent hypoxia is presented. The goal of the integrated picture is to address the types of responses that one might expect in humans exposed to one-time and repeated daily exposure to mild intermittent hypoxia. This form of intermittent hypoxia is highlighted because of its potential therapeutic impact in promoting functional improvement and recovery in several physiological systems.

The nerve sliding technique (NST) was introduced for repairing inferior alveolar nerve (IAN) defect and overcoming the disadvantages of conventional surgical treatment methods such as nerve graft. This study was conducted to identify factors associated with functional sensory recovery (FSR) following inferior alveolar nerve repair using the NST.

This was a retrospective cohort study including all patients who underwent IAN repair using the NST at Seoul National University Dental Hospital, Department of Oral and Maxillofacial Surgery from February 2009 to March 2020. The damaged part of the IAN was excised, and the incisive branch was transected intentionally to perform direct anastomosis without tension. Cox proportional hazard analysis was utilized to determine the relationships between predictor variables (age, gender, chief complaints, preoperative sensory results, duration from injury to repair, length of nerve tissue resected during the procedure, and neuroma formation) and outcome variable (time to FSR).

The sample was composed of 16 patients with a mean age of 56.1±10.1years, 25% were males and 75% were females. The mean nerve gap deficit was 7.69mm (3-15mm). Ten patients (62.5%) achieved FSR with a median time from operative treatment to FSR of 84.5days. Dental implant placement was found as the main cause for IAN injury (93.8%) and 56.2% of patients complained of hypoesthesia and dysesthesia. Factors associated with time to FSR at 1year were age, chief complaint, and early repair. Younger patients (P=.041) and patients without dysesthesia (P=.019) were more likely to achieve FSR. Caspase inhibitor reviewCaspases apoptosis Higher proportion of early repair group achieved FSR, although not statistically significant (P=.068).

The use of NST in repair of IAN defects up to 15mm achieved 62.5% FSR. Younger age and absence of dysesthesia were associated with higher FSR.

The use of NST in repair of IAN defects up to 15 mm achieved 62.5% FSR. Younger age and absence of dysesthesia were associated with higher FSR.