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With the growing increase in the older proportion of the world population, there is also an increase in specific age-related chronic diseases and conditions, including pain. We aimed to evaluate the association of sociodemographic factors with the presence and different degrees of pain intensity in people aged 65years and older.

The population-based study, conducted in 2013, included 3540individuals from Serbia. As pain predictors, we analyzed further sociodemographic characteristics gender, age, body mass index, level of education, marital status, and wealth index. For pain assessment, we used the pain domain of the SF-36 version 2.0 questionnaire.

People over the age of 85years are 27% more likely to have moderate pain than younger respondents; however, pain is less likely reported by men (by 42%), persons with overweight (by 23%) or obesity (by 21%), respondents with secondary (by 50%) or university education (29%), as well as those belonging to the upper household wealth index (by 22%), than by their counterparts.

Pain is less likely in people of age below 85years, male gender, those with higher educational level and higher wealth index, as well as overweight or obese individuals. Also, we have demonstrated that sociodemographic predictors differently correlate with the onset of the pain and its severity degree in persons of 65years and older.

Pain is less likely in people of age below 85 years, male gender, those with higher educational level and higher wealth index, as well as overweight or obese individuals. Also, we have demonstrated that sociodemographic predictors differently correlate with the onset of the pain and its severity degree in persons of 65 years and older.

The therapeutic effects of music have been known for thousands of years. Recently, studies with music interventions in patients with cardiovascular diseases yielded controversial results. The aim of this review is to provide an overview of the effects of receptive music intervention on the cardiovascular system.

We searched in PubMed, SCOPUS and CENTRAL for publications between January 1980 and May 2018. Primary endpoints were heart rate, heart rate variability and blood pressure. Secondary endpoints comprised respiratory rate, anxiety and pain. The quality of the studies was assessed by using the CONSORT statement and the Cochrane risk of bias assessment tool. Ameta-analysis and subgroup analyses concerning music style, gender and region were planned.

Atotal of 29studies comprising 2579patients were included and 18 studies with 1758patients investigated the effect of music on patients undergoing coronary angiography or open heart surgery. Torin 2 purchase Other studies applied music to children with congenital heart diseases, pregnant women with hypertension or patients with unstable angina. Due to high methodological study heterogeneity, ameta-analysis was not performed. The study quality was assessed as medium to low. In ten studies with higher quality comprising 1054patients, music intervention was not associated with significant changes in the cardiovascular endpoints compared to the control group. The subgroup analyses did not demonstrate any relevant results.

Currently no definite effect of receptive music intervention on the cardiovascular system can be verified. Further research is needed to assess music as an inexpensive and easy applicable form of therapy.

Currently no definite effect of receptive music intervention on the cardiovascular system can be verified. Further research is needed to assess music as an inexpensive and easy applicable form of therapy.

Since December 2019 coronavirus disease 2019 (COVID-19) outbreaks have occurred in China and many countries around the world. The effectiveness of oseltamivir on COVID-19 suspected outpatients without hypoxia was evaluated.

A total of 16COVID-19 suspected medical personnel and their cohabitation families without hypoxia, who came to the adult fever clinic from March to June 2020 were studied. All patients received antiviral therapy (oseltamivir) and antibacterial therapy together.

Most of the infected patients were female (10, 63%), 1 had diabetes (6%) and 3 hypertension (19%). The median age was 45years (interquartile range [IQR] 31-60 years). Oseltamivir administration made the temperature fall within 24 h in part (10, 63%). Clinical data were compared between patients receiving early treatment (ET) with oseltamivir, initiated within 24 h, and patients administered late treatment (LT), initiated after this time point. Duration of fever was shorter in the ET group than in the LT group (31 ± 21 h versus 94 ± 38 h; p < 0.001). The time from fever onset to treatment initiation correlated with duration of fever (r = 0.77; p < 0.001) and the time from peak to decline (r = 0.58; p < 0.05).

These findings suggest that early oseltamivir administration may lower the duration of fever in COVID-19 suspected outpatients without hypoxia when it is used in combination with antibacterial therapy.

These findings suggest that early oseltamivir administration may lower the duration of fever in COVID-19 suspected outpatients without hypoxia when it is used in combination with antibacterial therapy.

Advanced therapy-refractory parotid gland carcinomas have apoor prognosis with limited therapy options. We used molecular profiling to offer molecular guided therapies to patients with advanced metastatic parotid gland malignancies.

In this retrospective analysis we describe the molecular profiling of ten patients diagnosed with therapy-refractory metastatic parotid gland malignancies.

We identified seven genetic aberrations in five patients two mutations in CDKN2A and one mutation in APC, ATM, TP53, SMARCB1 and FGFR1, respectively. No mutations were detected in five patients. The IHC demonstrated frequent expressions of EGFR and p‑mTOR, as well as PTEN in eight patients. For four fifths (n = 8) of the patients, atargeted therapy was suggested. Eventually, three patients received the targeted therapy recommendation and one patient achieved stable disease for 14months.

A total of eight therapy recommendations were provided. Based on our observations, molecular-guided therapies may be afeasible treatment approach for this rare disease entity.