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Traditional manuscripts refer to plants such as Apium graveolens L. Fruit (celery seed), which could be used to improve sexual function among women. Since that time, local herbal shops in Iran continue to provide this herb as a natural aphrodisiac product.

This study aimed to evaluate the efficacy and safety of celery seed for the treatment of female sexual dysfunction.

In this parallel, randomized, double-blinded clinical trial, 80 women were assigned to receive either 500mg of celery seed or placebo 3 times a day for a period of 6 weeks (n=40 per group). The female sexual function index (FSFI) questionnaire was used to evaluate women’s sexual function before and after treatment.

At the end of the sixth week, an improvement in the total FSFI score was significantly greater in celery seed-treated women than those receiving the placebo (P<0.001). Increased total FSFI score is mainly contributed by improvement in the sexual desire (p<0.001), arousal (p<0.001), lubrication (p<0.001), and pain (p=0.033) domains at the endpoint of study. No serious side effects were noticed in both groups during the study period.

It seems that celery seed improved sexual function in women and could be used as a safe, well-tolerated, and effective herbal medicine in women with sexual dysfunction.

It seems that celery seed improved sexual function in women and could be used as a safe, well-tolerated, and effective herbal medicine in women with sexual dysfunction.

The dried root of Paeonia lactiflora Pall. (Radix Paeoniae) has been traditionally used to treat various inflammatory diseases in many Asian countries.

Cisplatin is a broad-spectrum anticancer drug used in diverse types of cancer. However, muscle wasting is a common side effect of cisplatin chemotherapy. Afatinib solubility dmso This study aimed to elucidate the effects of an ethanol extract of the root of Paeonia lactiflora Pall. (Radix Paeoniae, RP) on cisplatin-induced muscle wasting along with its molecular mechanism.

C57BL/6 mice were intraperitoneally injected with cisplatin and orally treated with RP. Megestrol acetate was used as a comparator drug. Skeletal muscle mass was measured as the weight of gastrocnemius and quadriceps muscles, and skeletal muscle function was measured by treadmill running time and grip strength. Skeletal muscle tissues were analyzed by RNAseq, western blotting, ELISA, and immunofluorescence microscopy.

In mice treated with cisplatin, skeletal muscle mass and skeletal muscle function were significantly reduced. However, oral administration of RP significantly restored skeletal muscle mass and function in the cisplatin-treated mice. In the skeletal muscle tissues of the cisplatin-treated mice, RP downregulated NF-κB signaling and cytokine levels. RP also downregulated muscle-specific ubiquitin E3 ligases, resulting in the restoration of myosin heavy chain (MyHC) and myoblast determination protein (MyoD), which play crucial roles in muscle contraction and muscle differentiation, respectively.

RP restored skeletal muscle function and mass in cisplatin-treated mice by restoring the muscle levels of MyHC and MyoD proteins via downregulation of muscle-specific ubiquitin E3 ligases as well as muscle NF-κB signaling and cytokine levels.

RP restored skeletal muscle function and mass in cisplatin-treated mice by restoring the muscle levels of MyHC and MyoD proteins via downregulation of muscle-specific ubiquitin E3 ligases as well as muscle NF-κB signaling and cytokine levels.

Atopic dermatitis (AD) is a complex skin disease with highly heterogeneous inflammation, which ranks among the largest component of the nonfatal diseases worldwide. The medications currently used to treat AD primarily include antihistamines, vitamin D and anti-inflammatory drugs, etc. But, the usage of these drugs is usually accompanied by various side-effects. Formononetin (FMN), a natural active ingredient of Astragalus membranaceus (Fisch.) Bunge, decreases the AD relapse rate, reduces recurring severity incidence and resists the inflammation in the initial stage of AD. However, the underlying mechanism of FMN on repressing the development of AD is still unknown.

To investigate the potential mechanism of FMN on relieving the initial responses of AD and elucidate its possible therapeutic targets in vivo and in vitro.

A fluorescein isothiocyanate (FITC)-induced mouse model of the initial stage of AD was established in vivo. Human keratinocytes (HaCaT) cells were co-stimulated with tumor necrosis factorzed by A20 siRNA (siA20). Moreover, compared with PPT (ERα agonist) and DPN (ERβ agonist), G1 could significantly increase the expression of A20. In addition, compared with MPP (ERα antagonist) and PHTPP (ERβ antagonist), G15 could markedly reduce the expression of A20. Furthermore, the effects of FMN on A20 were interfered by siGPER and G15 in vitro and in vivo.

These results demonstrated that FMN attenuated AD by upregulating A20 expression via activation of GPER. This new strategy might have effective therapeutic potential for AD and other inflammatory disorders.

These results demonstrated that FMN attenuated AD by upregulating A20 expression via activation of GPER. This new strategy might have effective therapeutic potential for AD and other inflammatory disorders.Pseudomonas plecoglossicida is a highly lethal causative agent associated with severe economic losses in aquaculture industry. P. plecoglossicida has been documented as a highly alarming pathogen in a wide variety of freshwater cultured fish including ayu (Plecoglossus altivelis), rainbow trout (Oncorhynchus mykiss) and pejerrey (Odontesthes bonariensis), and marine cultured fish such as large yellow croaker (Larimichthys crocea) and orange-spotted grouper (Epinephelus coioides) etc. Fish infected with P. plecoglossicida usually exhibited various symptoms, including lethargy, inappetence, disorientation, abdominal swelling with severe ascites and numerous white spots covered on the surface of spleen tissue. In present study, barramundi, zebrafish, spotted seabass and mandarinfish were investigated as potential hosts of P. plecoglossicida. Among them, barramundi was confirmed the most sensitive host fish species for P. plecoglossicida infection. Dynamic histopathology revealed that P. plecoglossicida caused various histopathological effects to barramundi a) spleen granulomas appeared at 2 days post infection (dpi) and matured at 4 dpi; b) liver steatosis at 1 dpi and fat necrosis over time, and damaged the most compared to spleens and metanephros; c) metanephros Bowman capsule space became larger and glomerulus shrank were even collapsed at 1 dpi; d) ascites either bacterium or melanin were wrapped in cells from ascites.