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411, 0.377, and 0.523) beyond that explained by demographic and burn-related variables. More avoidance and less approach coping predicted greater PTSD and/or depression symptoms post-burn. More approach coping and greater social support strongly predicted higher PTG post-burn. Conclusion Rates of probable PTSD and MDD were relatively high in burn survivors, however, PTG was also highly prevalent. Coping styles and social support may play distinct roles in psychosocial adjustment after burn injury.Background Previous studies have suggested that the right anterior insula (rAI) plays a vital role in salience processing and stress-related disorders. In this study, we aimed to investigate the relationship between rAI functional connectivity changes and individual differences in cortisol responses after acute stress, in order to provide insights into psychiatric illness vulnerabilities. Methods Thirty-five young men were enrolled in a randomized, counterbalanced two-session study, with aversive movie clip combined with electrical shocks as stress stimulation and the neutral movie clip as control stimulation. Resting-state fMRI data was acquired after movie exposure. The rAI was chosen as seed for functional connectivity analysis. We then examined the effect of acute stress on rAI functional connectivity and its association with individuals’ cortisol response. Results We found decreased rAI functional connectivity in the fronto-parietal regions, but increased functional connectivity in the visual and somatosensory areas following acute stress. SEL120-34A Moreover, stress-induced cortisol response was significantly positively correlated with the rAI functional connectivity in the medial prefrontal cortex, and negatively correlated with the orbital-frontal cortex, lingual gyrus, and middle temporal gyrus. Limitations Only young Chinese males without any trauma experience were recruited in this study. Conclusions The results suggested tight link between specific rAI functional connectivity alterations and individual stress reactivity, which may help elucidate the potential neurobiological mechanism underlying vulnerability to stress-related disorders.Background In order to experimentally asses the role of socio-emotional problems in Eating Disorder (ED) psychopathology, we have measured affective states and ED-related attitudes in response to an acute psychosocial stress and their relationships with interpersonal sensitivity in people with Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Methods Twenty-one women with AN, 21 with BN and 27 healthy women underwent an acute psycho-social challenge, the Trier Social Stress Test. Anxiety feelings, hunger perception, amount of desired food and body dissatisfaction were measured throughout the experimental procedure. The relationships between these variables and with interpersonal sensitivity measures were explored through Pearson’s correlation and mediation analyses. Results Stress-induced anxiety was increased in people with EDs. People with AN showed reduced hunger perception, decreased desire for food and a negative association between anxiety feelings and desire for food. In people with EDs, baseline ineffectiveness predicted post-stress body dissatisfaction through the mediation of post-stress anxiety levels. Limitations The relatively low sample size and the lack of an experimental control condition are the main limitations of the study. Conclusions The present findings show, for the first time, the relationships between socio-emotional distress and ED-related attitudes in people with EDs, providing experimental support to the interpersonal model of EDs. This gives empirical evidence to treatments targeting interpersonal problems in EDs.Background A positive association between early-life famine exposure and depression has been demonstrated. However, the mechanisms by which famine exposure in early life leads to late-life depression remains unclear. The present study examines the impact of leukocyte telomere length (LTL) and/or religiosity on the relationship between early-life famine exposure and late-life depression in a Chinese minority sample. Methods A cross-sectional study of community-dwelling adults aged 55 or older was conducted in the Ningxia province of western China from 2013 to 2016. Multivariate ordinal logistic regression was used to examine the association between famine exposure and depression status, and a series mediation model was constructed to identify the mediation role of LTL and religiosity. Results Compared with famine exposure during adulthood, fetal famine exposure was associated with a higher risk of late-life depression (adjusted odds ratio of 3.17, 95% CI 1.36-7.38). A cumulative effect of fetal famine exposure on the risk of late-life depression was observed. Participants born in 1961 (the third year of the famine) had the strongest association with late-life depression. LTL played a mediating role in the association between famine exposure and depression which accounted for 21% of the total effect. Limitations The cross-sectional design prevents causal inferences regarding the relationships between famine and depression. Conclusions Fetal famine exposure was associated with an increased risk of late-life depression in a Chinese minority community-dwelling population. Telomere shortening partially mediated this association.Background Neuroticism is one of the important traits of personality, which has strong genetic components. However, the underlying genetic mechanism is still unclear. Methods To better understand the genetic basis of neuroticism, we conducted an integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) data. The GWAS data of neuroticism was derived from a published study of neuroticism (including 170,906 subjects). Life course consistent meQTLs were obtained from a large scale longitudinal meQTLs analysis (including 1,018 mother-child pairs).Gene prioritization, pathway and tissue/cell type enrichment analyses were implemented by DEPICT. Results We identified multiple genes, pathways and tissues associated with neuroticism, such as NEIL2 (P value = 1.31 × 10-2), ARHGAP27 (P value = 1.40 × 10-2), REACTOME_CLATHRIN_DERIVED_VESICLE_BUDDING(P value =4.92 × 10-6) ,REACTOME_TRANSGOLGI_NETWORK_VESICLE_BUDDING (P value =4.92 × 10-6), frontal lobe(P value =3.