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almost no recurrences after resection, careful follow-up for longer periods is required.An intraoperative functional spinal cord monitoring system is a technology used by spine and spinal cord surgeons to perform a safe surgery and to gain further surgical proficiency. However, no existing clinical neurophysiological method used in the operating room can monitor all complex spinal cord functions. Therefore, by observing the activities of certain neural action potentials transferred via limited neural tissues, surgeons need to deductively estimate the function of the whole spinal cord. Thus, as the number of spinal cord functions that need to be observed increases, spinal cord monitoring can be more reliable. However, in some situations, critical decision-making is affected by the limited capability of these methods. Nevertheless, good teamwork enables sharing of seamless information within the team composed of a surgeon, anesthesiologist, monitoring technician and nurses greatly contributes to making quick and accurate decisions. The surgeon, who is the person in charge of the team, should communicate with multidisciplinary team members using common technical terms. For this reason, spine and spinal cord surgeons must have appropriate knowledge of the methods currently used, especially of their utility and limitations. To date, at least six electrophysiological methods are available for clinical utilization three are used to monitor sensory-related tracts, and three are used to monitor motor-related spinal cord functions. If surgeons perform electrode setting, utilizing their expertise, then the range of available methods is broadened, and more meticulous intraoperative functional spinal cord monitoring can be carried out. Furthermore, if the team members share information effectively by utilizing a clinically feasible judicious checklist or tools, then spinal cord monitoring will be more reliable.

The aim of this study was to examine, using PubMed, the number of articles in the field of physical medicine and rehabilitation medicine originating in Japan, especially those containing high-quality scientific evidence (randomized controlled trials [RCTs], systematic reviews, meta-analyses) and those published in high impact factor journals.

We searched the PubMed database to identify articles, RCTs, systematic reviews, and meta-analyses from Japan covering physical medicine and rehabilitation published between 2001 and 2019; we then calculated the proportion of articles from Japan. Additionally, using Journal Citation Reports, we selected the top ten highest impact factor journals on “Rehabilitation” each year between 2001 and 2019. For each year, we searched PubMed for the total number of articles in these top ten journals and for articles originating in Japan. The Cochran-Armitage test was used to evaluate the change in the proportion of publications from Japan over time.

The proportion of articles on physical medicine and rehabilitation originating in Japan increased from 2001 to 2019 (P<0.0001). An increase in the percentages of systematic reviews (P=0.046) and meta-analyses (P=0.0013) originating in Japan and a decrease in the percentage of original articles published in the top ten highest impact factor journals were demonstrated (P=0.002). However, there was no change in the percentage of RCTs from Japan over time (P=0.055).

Our findings suggest that the proportion of articles from Japan containing high-quality scientific evidence is increasing. However, there is a need to expand the support system for research while considering the quality of research.

Our findings suggest that the proportion of articles from Japan containing high-quality scientific evidence is increasing. However, there is a need to expand the support system for research while considering the quality of research.

Adrenomedullin (AM), a vasodilatory peptide, is known for its pleiotropic actions. AM levels are increased under inflammatory conditions such as sepsis and can be useful as a prognostic biomarker. However, there are only a few reports on the physiological actions of AM in the perioperative period. The aim of this single-center, prospective, and observational study was to investigate the changes in the plasma levels of mature AM (mAM) and total AM (tAM) observed during the perioperative period. NSC697923 clinical trial In addition, we aimed to determine the association between each AM level and immune-inflammatory parameters to explore the usefulness of AM as a biomarker of the magnitude of surgical stress responses.

The levels of both mAM and tAM, in addition to the levels of presepsin, interleukin-6, procalcitonin, white blood cell, and C-reactive protein, were measured in blood samples obtained during the perioperative period. Other laboratory data, including sequential organ failure assessment (SOFA) and acute physiology and crgical patients.

This observational study was retrospectively registered with Japanese Clinical Trial Registry “UMIN-CTR” on March 19, 2018, and was given a trial ID number UMIN000031792.

This observational study was retrospectively registered with Japanese Clinical Trial Registry “UMIN-CTR” on March 19, 2018, and was given a trial ID number UMIN000031792.

Polymerase γ (POLG) is a protein that plays a pivotal role in the replication of the mitochondrial genome. POLG-related disorders constitute a sequence of overlying phenotypes that can present from early infancy to late adulthood. Parkinsonism is the most common movement disorder associated with POLG mutation. We also summarize all reported cases of POLG-related Parkinsonism, along with a literature review.

We present the case of an 80-year-old male presented with complaints of episodic confusion, tremors, and restlessness. He has been on risperidone for psychosis. A normal DaT scan ruled out Parkinson’s disease, and molecular analysis for POLG was positive (E1143G). He was diagnosed with drug-induced Parkinsonism and tardive akathisia with an incidental POLG mutation.

A literature search revealed 55 cases of “POLG-related Parkinsonism” that met our criteria. These mutations can clinically affect multiple organ systems. Parkinsonism is the most common movement disorder reported in association with POLG mutations.