Activity

The Mg-6.8Y-2.5Zn-0.4Zr (WZ73) alloy exhibits different microstructure characteristic after conventional casting compared to the twin-roll cast (TRC) state. Twin-roll casting results in a finer microstructure, where the LPSO phases are more finely distributed and less strongly connected. A transfer of the hot deformation behavior from the as-cast condition to the TRC condition is only possible to a limited extent due to the microstructural differences. Both states show differences in the recrystallization behavior during hot deformation. In the conventional cast state, dynamic recrystallization (DRX) is assumed to be delayed by the occurrence of coarse blocky LPSO phases. Main DRX mechanisms are continuous dynamic recrystallization (CDRX), particle stimulated nucleation (PSN) and twin induced dynamic recrystallization (TDRX). The deformed TRC sample showed pronounced DRX at almost all deformation conditions. Besides the TDRX and the PSN mechanism, kink induced dynamic recrystallization (KDRX) can be observed. Optimum deformation conditions for both states are temperatures from 500 °C to 520 °C, and strain rates ranging from 0.01 s-1 to 0.1 s-1 for the as-cast material as well as a strain rate of 1 s-1 for the TRC material.

We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS

nanosheets for postoperative tumor re-occurrence inhibition. However, owing to that the nanofibrous mat is un-injectable, this composite nanofiber is far from being clinically applicable.

Via modulating the electrospray parameters, polyvinyl alcohol (PVA) beads string doped with DOX and MoS

(PVA/MoS

/DOX microspheres) were prepared, which were further crosslinked with glutaraldehyde to obtain the water-stability.

Under the 808-nm laser irradiation, MoS

nanosheets rendered the prepared PVA/MoS

/DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. Besides, the heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres.

PVA/MoS

/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS

/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer.

PVA/MoS2/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS2/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer.Gut microbiota dysbiosis is a common feature in colorectal cancer (CRC) and inflammatory bowel diseases (IBD). Adoption of the Mediterranean diet (MD) has been proposed as a therapeutic approach for the prevention of multiple diseases, and one of its mechanisms of action is the modulation of the microbiota. We aimed to determine whether MD can be used as a preventive measure against cancer and inflammation-related diseases of the gut, based on its capacity to modulate the local microbiota. A joint meta-analysis of publicly available 16S data derived from subjects following MD or other diets and from patients with CRC, IBD, or other gut-related diseases was conducted. We observed that the microbiota associated with MD was enriched in bacteria that promote an anti-inflammatory environment but low in taxa with pro-inflammatory properties capable of altering intestinal barrier functions. We found an opposite trend in patients with intestinal diseases, including cancer. Some of these differences were maintained even when MD was compared to healthy controls without a defined diet. Our findings highlight the unique effects of MD on the gut microbiota and suggest that integrating MD principles into a person’s lifestyle may serve as a preventive method against cancer and other gut-related diseases.

Trees are good sources of bioactive compounds as antifungal and antioxidant activities.

Management of six molecularly identified

isolates (F. oxy 1, F. oxy 2, F. oxy 3, F. oxy 4, F. oxy 5 and F. oxy 6, under the accession numbers MW854648, MW854649, MW854650, MW854651, and MW854652, respectively) was assayed using four extracts from

leaves,

bark,

wood and

leaves. All the extracts were analyzed using HPLC-VWD for phenolic and flavonoid compounds and the antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and

-carotene-linoleic acid (BCB) bleaching assays.

In mg/kg extract, the highest amounts of polyphenolic compounds

-hydroxy benzoic, benzoic, gallic, and rosmarinic acids, with 444.37, 342.16, 311.32 and 117.87, respectively, were observed in

leaf extract; gallic and benzoic acids with 2551.02, 1580.32, respectively, in

bark extract; quinol, naringenin, rutin, catechol, and benzoic acid with 2530.22, 1224.904, 798.29, 732.28, and

leaf as a potent antioxidant agent.

Extracts from A. saligna bark and C. maculatum leaves are considered potential candidates against the growth of F. oxysporum isolates-a wilt pathogen-and C. maculatum leaf as a potent antioxidant agent.The growing antimicrobial resistance (AMR) of pathogenic organisms to currently prescribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the increasing drug resistance, there is a pressing need for novel antimicrobial agents, especially from non-conventional sources. Several natural products (NPs) have been shown to display promising in vitro activities against multidrug-resistant pathogens. SBI-115 cell line Still, only a few of these compounds have been studied as prospective drug candidates. This may be due to the expensive and time-consuming process of conducting important studies on these compounds. The present review focuses on applying cheminformatics strategies to characterize, prioritize, and optimize NPs to develop new lead compounds against antimicrobial resistance pathogens. Moreover, case studies where these strategies have been used to identify potential drug candidates, including a few selected open-access tools commonly used for these studies, are briefly outlined.