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We cannot rule out that despite our rigorous methods and robustness checks, design-inherent limitations of the ITS study as well as country-specific factors, such as the ambivalent German policy context have influenced our estimation of the effects of the legislation.Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5′ end of HBX in CI patients and compared it with that of patients in other clinical stages. Fifty-eight HBeAg-negative patients were included 16 CI, 19 chronic hepatitis B, 16 hepatocellular carcinoma and 6 liver cirrhosis. Quasispecies complexity and conservation were determined in the region between nucleotides 1255 and 1611. Amino acid changes detected were tested in vitro. CI patients showed higher complexity in terms of mutation frequency and nucleotide diversity and higher quasispecies conservation (p  less then  0.05). A genotype D-specific pattern of mutations (A12S/P33S/P46S/T36D-G) was identified in CI (median frequency, 81.7%), which determined a reduction in HBV DNA release of up to 1.5 log in vitro. CI patients showed a more complex and conserved viral quasispecies than the other groups. The genotype-specific pattern of mutations could partially explain the low viremia observed in these patients.Oceanic gateways have modulated ocean circulation and have influenced climatic variations throughout the Earth´s history. During the late Miocene (7.8-7.35 Ma), the Atlantic Ocean and the Mediterranean Sea were connected through the Rifian Corridor (Morocco). This gateway is one of the few examples of deep ancient seaways with a semi-continuous sedimentary record. Deposits comprise turbidites intercalated between deep-sea mudstone (i.e., hemipelagites and drift deposits), channelized sandstone contourite facies, and shallow marine sandstone. Herein an ichnological analysis was conducted in these upper Miocene sediments to improve characterisation of palaeoenvironmental conditions. In addition, ichnofacies were analysed to elucidate how bottom currents control ichnofacies distribution and can modify their attributes. Turbidite deposits are typified by vertical trace fossils (i.e., Ophiomorpha), conforming the Ophiomorpha rudis ichnosubfacies. Contouritic sandstone exhibits high density and low diversity trace-fossil assemblage, with predominant Macaronichnus and Scolicia, resembling a proximal expression of the Cruziana ichnofacies. Shallow marine environments are dominated by vertical trace fossils (e.g., Conichnus, Ophiomorpha, Skolithos), allowing an assignation to the Skolithos ichnofacies. This study reveals for the first time a variability in ichnofacies attributes and distribution at the Rifian Corridor, associated with turbidites, contourite and shallow marine sediments. Hydrodynamic energy reveals as the major factor controlling trace maker communities in the studied seaway. Highly energetic conditions typical of shallower settings are present in deeper-water environments (i.e., slope), contributing to ichnodiversity impoverishment in ichnofacies.The superconducting systems emerging from topological insulators upon metal ion intercalation or application of high pressure are ideal for investigation of possible topological superconductivity. In this context, Sr-intercalated Bi[Formula see text]Se[Formula see text] is specially interesting because it displays pressure induced re-entrant superconductivity where the high pressure phase shows almost two times higher [Formula see text] than the ambient superconducting phase ( [Formula see text] K). Interestingly, unlike the ambient phase, the pressure-induced superconducting phase shows strong indication of unconventional superconductivity. However, since the pressure-induced phase remains inaccessible to spectroscopic techniques, the detailed study of the phase remained an unattained goal. Here we show that the high-pressure phase can be realized under a mesoscopic point contact, where transport spectroscopy can be used to probe the spectroscopic properties of the pressure-induced phase. We find that the point contact junctions on the high-pressure phase show unusual response to magnetic field supporting the possibility of unconventional superconductivity.

Dysregulated microRNA (miRNA) expression could provide a mechanism linking firefighter exposure to increased cancer risk.

To determine if changes in longitudinal miRNA expression in firefighters are associated with occupational exposures.

Whole blood MiRNA was evaluated in 52 new recruits prior to live-fire training and 20-37 months later. Linear mixed effects models adjusted for age, ethnicity, BMI, and batch effects were used to determine associations separately for all fires and structure fires only between employment duration, cumulative fire-hours and fire-runs, and time since most recent fire with (1) nine a priori and (2) the full array of 799 miRNAs.

For multivariable models including all fires, two a priori miRNAs were associated with employment duration and four with time since most recent fire. For multivariable models restricted to structure fires, three a priori miRNAs were associated with employment duration and one with fire-runs. Additional miRNAs from the full array were associated with employment duration for all fires and/or structure fires. In general, tumor suppressive miRNAs decreased and oncogenic miRNAs increased with exposure.

Changes in miRNAs may serve as biomarkers of exposure effects and a mechanism for increased cancer risk in firefighters.

Changes in miRNAs may serve as biomarkers of exposure effects and a mechanism for increased cancer risk in firefighters.

There is a growing evidence that exposure to ambient particulate air pollution during pregnancy is associated with adverse birth outcomes, including reduced birth weight (BW). The objective of this study was to quantify associations between BW and exposure to particulate matter (PM) and biomass burning during pregnancy in Thailand.

We collected hourly ambient air pollutant data from ground-based monitors (PM with diameter of <10 µm [PM

], Ozone [O

], and nitrogen dioxide [NO

]), biomass burning from satellite remote sensing data, and individual birth weight data during 2015-2018. selleck chemical We performed a semi-ecological analysis to evaluate the association between mean trimester exposure to air pollutants and biomass burning with BW and low-birth weight (LBW) (<2500 g), adjusting for gestation age, sex, previous pregnancies, mother’s age, heat index, season, year, gaseous pollutant concentrations, and province. We examined potential effect modification of PM

and biomass burning exposures by sex.

There were 83,931 eligible births with a mean pregnancy PM

exposure of 39.