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Results for each combination therapy were compared to radiotherapy or hyperthermia without resveratrol. Results Both irradiation or hyperthermia could reduce viability of MCF-7 cells. Furthermore, the regulation of Bax and caspase genes increased, while Bcl-2 gene expression reduced. Resveratrol potentiated the effects of radiation and hyperthermia on MCF-7 cells. Conclusion Results of this study suggest that resveratrol is able to induce the regulation of pro-apoptotic genes and attenuate the viability of MCF-7 cells. This may indicate the sensitizing effect of resveratrol in combination with both radiotherapy and hyperthermia.Aim and objective Methyldopa is one of the medications that is used for the treatment of hypertension. Therefore, the determination of methyldopa in the presence of other biological components is essential. In this work, a promising electrochemical sensor based on CoFe2O4 magnetic nanoparticles modified glassy carbon electrode (CoFe2O4/GCE) was developed for electrochemical determination of methyldopa in the presence of uric acid. Cobalt ferrite nanoparticles were synthesized via chemical methods. Materials and methods Characterizing the CoFe2O4 was investigated by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), and cyclic voltammetry techniques. Results Under the optimal experimental conditions, the current response of the electrochemical sensor obtained with differential pulse voltammetry was increased linearly in the range from 1.45 to 15.1 µmol L-1 with the detection limit of 1.07 µmol L-1 for methyldopa. Also, by using the proposed method, methyldopa and uric acid could be analyzed in a mixture independently. The difference in peak potential for analytes is about 150 mV. see more Conclusion The present sensor was successfully applied for the determination of methyldopa in the presence of uric acid in biological samples and the pharmaceutical samples with satisfactory results.Background Flaxseed (Linum usitatissimum) is an oil-based seed which contains high amounts of alpha-linoleic acid, linoleic acid, lignans, fiber and many other bioactive components which is suggested for healthier life. Nowadays flaxseed is known as a remarkable functional food with different health benefits for humans and protects against cardiovascular disease, diabetes, dyslipidemia, obesity and altogether metabolic syndrome. Objectives and methods To review the bioactive components of flaxseed and their potential health effects, PubMed and Scopus were searched from commencement to July 2019. Keywords including ‘flaxseed’, ‘Linum usitatissimum’, ‘metabolic syndrome’, ‘obesity’, ‘inflammation’, ‘insulin resistance’, ‘diabetes’, ‘hyperlipidemia’ and ‘menopause’ were searched in the databases with varying combinations. Conclusions Consumption of flaxseed in different forms has valuable effect and protects against cardiovascular disease, hypertension, diabetes, dyslipidemia, inflammation and some other complications. Flaxseed can serve as a promising candidate for management of metabolic syndrome to control blood lipid levels, fasting blood sugar, insulin resistance, body weight, waist circumference, body mass and blood pressure.Aim and objective Myocardial infarction, cerebral infarction and other diseases caused by vascular obstruction have always jeopardized human life and health. More and more reports indicate that Rhei Radix et Rhizoma has a good clinical effect in the prevention and treatment of cardiovascular disease. Owing to the complexity of herbal medicine, the pharmacodynamic mechanism of Rhei Radix et Rhizoma is still not clear. The objective of this study was to explore the two-way adjustment mechanism of Rhei Radix et Rhizoma and provided a new solution for the prevention and treatment of cardiovascular disease. Materials and methods Based on the systems pharmacology method and big data analysis technology, this study used data mining, reverse pharmacophore matching, network construction, GO and KEGG Analysis, and molecular docking to investigate the two-way adjustment mechanism of Rhei Radix et Rhizoma. Results The results suggest that Rhei Radix et Rhizoma plays a two-way adjustment of activating blood circulation ase of the drugs. This study provides a material basis for the development of new blood-activating drugs based on natural medicines.Stress gastric ulceration is a clinical condition leading to morbidity/mortality and complex etiopathological factors are involved. Pharmacotherapy of such gastric mucosal lesions is not consistent and novel strategies are being explored. Targeting gastrointestinal factors have showed equivocal results and there is a possibility of involvement extra-gastrointestinal factors. Stress is a highly interactive biological response in which the brain plays a key role. The involvement of brain substrates like the limbic system (amygdala, cortex, hippocampus) and behavioral traits have been investigated and research data has shown that the limbic brain-gut axis may be involved in the regulation of gastric mucosal integrity during stressful situations. The amygdaloid complex, its connections with other limbic structures and their neural networks act in tandem to contribute to both stress ulceration and gastroprotection. Complex neurotransmitter interactions in these areas involving biogenic amines and neuropeptides havof their ant-stress profile. Further, their interactions with brain neurotransmitters and immune mechanisms and their relative safety could make them prospective leads for stress ulcer prophylaxis and treatment.The review considers the data on physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focus on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on re-evaluation of the traditional notion that stressproduced glucocorticoids are ulcerogenic led us to opposite conclusion suggested that these hormones play an important role in maintenance of the gastric mucosal integrity. Exogenous glucocorticoids may exert both gastroprotective and proulcerogenic effects. Initially gastroprotective effect of dexamethasone but not corticosterone, cortisol or prednisolone can be transformed to proulcerogenic one. The most significant factor for the transformation is the prolongation of its action rather the dose. Gastrointestinal injury can be accompanied by changes of somatic pain sensitivity and glucocorticoids contribute to these changes playing physiological and pathological role.