Activity

In the muscle, treatment with fluoridated water increased the expression of proteins related to muscle contraction, while in the liver, there was an increase in expression of antioxidant proteins and in proteins related to carboxylic acid metabolic process. Remarkably, phosphoenolpyruvate carboxykinase (PEPCK) was found exclusively in the liver of control mice. The reduction in PEPCK, a positive regulator of gluconeogenesis, thus increasing glucose uptake, might be a probable mechanism to explain the anti-diabetic effects of low doses of F, which should be evaluated in further studies. Dysregulated activation of the MET tyrosine kinase receptor is implicated in the development of solid tumors and can arise through several mechanisms, including gene amplification, overexpression of the receptor and/or its ligand hepatocyte growth factor (HGF), and the acquisition of activating mutations. The most common activating mutations cause exon 14 to be skipped during MET mRNA splicing. This in-frame deletion, known as MET exon 14, results in production of a shortened receptor that lacks a juxtamembrane domain but retains affinity for HGF. However, the negative regulatory function located within this protein sequence is lost, leading to receptor accumulation on the cell surface and prolonged activation by HGF. MET mutations causing exon 14 skipping appear to be true oncogenic drivers and occur in patients and tumors with distinct characteristics. Increasing evidence suggests that tumors carrying such mutations are sensitive to MET inhibition, raising the hope that selective MET inhibitors will provide patients with optimal anticancer activity with minimal toxicity. We discuss the prospects for selective MET inhibitors in the treatment of non-small cell lung cancer harboring MET exon 14 skipping. Water body, as water cool islands (WCIs), is an effective factor of mitigating the urban heat island (UHI) effects through the evaporation and absorption of solar shortwave radiance. In this study, a combination of the range, amplitude, efficiency and capacity of the WCI effect (WCI_R, WCI_A, WCI_E and WCI_C as descriptors) within water buffers, is proposed to evaluate the interannual variation of the seasonal WCI effects within the fifth loop of Beijing from 2000 to 2018, further construct optimal regression models by seven impact factors with the four WCI descriptors through all-subset regression, as well as calculate the independent contribution rate (CR) of these factors by hierarchical partitioning (HP) analysis. The results indicate that (1) In terms of the interannual variation of WCI effects, the most significant trends that rise over fall produced by four descriptors generate in summer after 2009, while relatively stable states exist in spring and winter. (2) As for the impact factors, the water temperature (WT) and the percentage of vegetation (PV) contribute most for WCI_R, WCI_A and WCI_E in reaction to the interannual average, while the water temperature capacity (WTC) maintains significant impact on WCI_C from spring to autumn over 18 years but shares power with water temperature (WA) and WT in winter. (3) Considering the factor changes yearly, the dominance relationships of external ones, mainly the percentage of impervious surface (PI) and PV, gradually surpass that of WA and WTC in four seasons especially after 2009. On this basis, urban designers could propose suitable plans to better exert the cooling effect of water bodies, thereby reducing the UHI effect. V.Hydrochar microspheres supported Al catalysts with hierarchically porous structure (Al/HPHMs) for glucose to fructose isomerization were fabricated. Superior catalytic selectivity (93.3%) and fructose yield (32.6%) were achieved in aqueous under 160 °C for 20 min. Hierarchically porous structure was formed after KHCO3 and K2CO3 activation and the roles of KHCO3 and K2CO3 in controlling the Al phase and tailoring morphology of hydrochar supported Al were evaluated. The major active sites were characterized as Al hydroxides including β-Al(OH)3, γ-Al(OH)3, γ-AlO(OH), Al-C-O linkages. TAK-242 Active sites by KHCO3 activation with high contents of Al-C-O and Al(OH)3 have better selectivity. Oxygen-containing functional groups including aluminum‑oxygen groups on the hydrochar microspheres have contributed to the formation of hydrogen bond and π-π interactions between glucose and Al species. Green process synthesized aluminum-hydrochars have potential for their application as a variety of stable, recyclable, and efficient catalysts for lignocellulosic biorefining. Simulated nitrogen deposition experiments in forests have mainly used understory nitrogen application, i.e., they failed to consider how canopy interception may alter the effects of nitrogen deposition on forest plants. This study used canopy addition of nitrogen, understory addition of nitrogen, and no-nitrogen addition control to study the effect of nitrogen deposition on the allocation of carbon assimilation products of representative woody species in an evergreen broad-leaved forest. Results showed that the maximum photosynthetic rate (Asat) of Blastus cochinchinensis (a shrub), Ardisia quinquegona (a small tree), and Schefflera octophylla (a small tree) were significantly higher, but Asat of Schima superba (a large tree) was significantly lower under canopy addition of nitrogen than under the control. Canopy and understory additions of nitrogen did not change Asat of Lasianthus chinensis (a shrub). Compared with the control, leaf chemical compositions of these plants were differentially changed by canopyergreen broad-leaved forests into shrublands. Both climate warming and co-contamination of polycyclic aromatic hydrocarbons (PAHs) and heavy metals are environmental issues of great concern. However, the interactive effects of warming and heavy metals on PAH accumulation in edible plants and the PAH-associated health risk remain unclear. In this study, enclosed soil/water-air-plant microcosm experiments were conducted to explore the effects of copper (Cu), warming (+6 °C), and their combination on the uptake of four deuterated PAH (PAH-d10) by spinach (Spinacia oleracea L.) in aged soil. PAH-associated health risks for soil, plant, and air exposure pathways were also assessed. The results showed that both individual Cu or warming decreased the PAH-d10 concentrations in root and shoot (non-normalized by lipid content) as well as the total PAH-associated cancer risk. Although antagonism existed between warming and Cu, compared to the presence of Cu, warming further reduced the spinach uptake of PAHs-d10 and total PAH-associated cancer risk, and the reductions were stronger at higher Cu levels.