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An anterior cruciate ligament (ACL) injury in children is a devastating injury. After an ACL injury 1 in 3 children obtain a second injury of the ipsilateral or contralateral ACL. Children who suffer an ACL injury also have a ten times higher risk of osteoarthritis. Preventative training programmes can decrease the risk of acute knee injuries in young sportspeople; however, implementation of these prevention programmes is challenging, so it is important to inform associations, clubs, youth trainers and parents about the added value of these programmes. Children with ACL injuries must receive specialized guidance during rehabilitation, regardless of whether they have been treated conservatively or surgically. Because of the risk of a second ACL injury,we recommend that children should not to return to pivoting sports until at least 12 months after surgery for ACL.On 3 March 2020, the document ‘Drug treatment options for patients with COVID-19 (infections with SARS-CoV-2)’ was published on the website of the Dutch Working Party on Antibiotic Policy (StichtingWerkgroepAntibioticabeleid, SWAB). Based on a 7-step analysis of the literature, hydroxychloroquine (HCQ) and chloroquine (CQ) were initially included in the SWAB document as possible drug treatments for hospitalised adult COVID-19 patients. However, recent weeks have seen the publication of the results of various studies into the effectiveness of treatment with HCQ and CQ in patients with COVID-19. On the basis of these results, we conclude that there is insufficient evidence to consider HCQ and CQ as meaningful treatment options in patients with COVID-19. Clinically relevant QTc prolongation occurs in at least 1 in 10 COVID-19 patients treated with HCQ or HQ.

To determine whether children play a role in the transmission of SARS-CoV-2 to other children and adults, and to gain insight into symptomatic and asymptomatic infections in children.

Analysis of national COVID-19 notifications and prospective observational study in families with children.

Information about COVID-19 patients and their contacts was obtained from the registration systems used by the public health services. In an ongoing study, patients with COVID-19 were asked to participate if they have a family with children. On two occasions nose-throat swabs and blood were collected for PCR analysis and determination of antibodies against SARS-CoV-2.

The notifications suggest that transmission finds place mainly between adults and to a lesser extent between parents and children. For the family study, data were available from 54 households with a total of 227 participants. In families of a confirmed COVID-19 patient, children between 1 and 11 years were less often positive in PCR and serology than older children and adults.

The study gives no indications that children play an important role in the transmission of SARS-CoV-2. Children can indeed become infected, but transmission mainly takes place between adult peers and from adult family members to children. Transmission among children or from children to adults, as is known in influenza, appears to be less common. Ongoing studies should provide important information for further decision-making on control measures, such as closure of schools.

The study gives no indications that children play an important role in the transmission of SARS-CoV-2. Children can indeed become infected, but transmission mainly takes place between adult peers and from adult family members to children. Transmission among children or from children to adults, as is known in influenza, appears to be less common. Ongoing studies should provide important information for further decision-making on control measures, such as closure of schools.COVID-19 first appeared in the Netherlands at the end of February 2020. selleck chemicals llc North Brabant province was the epicentre, which led the municipal health service (GGD) ‘Hart voor Brabant’ to register 1495 cases in a single month in its area. As the GGD spearheaded the fight, it was faced with a rapid increase to a major epidemic. We describe the experiences of the GGD ‘Hart voor Brabant’ on the basis of a GGD’s responsibilities. An epidemic consists of several stages, each with its own focus with respect to source and contact tracing and diagnostic testing. An epidemic of this magnitude is usually associated with common healthcare challenges, for example limited availability of diagnostic resources and personal protective equipment. Now that the government is easing the measures, early source identification and rapid start-up of contact tracing are particularly important. The big challenge now is to convince COVID-19 patients’ contacts to stick to all control measures.People with autism spectrum disorders (ASD) relatively often experience suicidality. This seems partly related to comorbid disorders such as depression, ADHD and addiction. In addition, people with ASD are relatively vulnerable due to limitations in social communication, for example for bullying behavior of others. This, too, plays a role in suicidality, as well as having a strong tendency to ruminate and difficulty regulating emotions. Particularly in women with ASD, we see increased suicidality; possibly because they have more comorbid disorders, but also because of their tendency to camouflage and compensate. Social support and a sense of belonging do not protect people with ASD against suicidality. Practical help does seemtobe a protective factor. In clinical practice, health professionals should be aware of possible suicidality in people with ASD. Treatment of comorbidity and emotion regulation problems, as well as the practical guidance and the use of good anti-bullying programs can play an important role in this.Currently, in the Netherlands, there is wide debate about the legalization of assisted suicide of older people who consider their lives to be “completed” without being severely ill. Robust scientific knowledge is required for careful policy decisions. Since 2012, I have been doing research in this field. In this article, I map out the current state of play which older people are we talking about? What are the circumstances and characteristics of older people who have a death wish while not having a severe illness? And what is the nature of their death wish? The findings demonstrate that the term “completed life” is inappropriate within this framework. It seems better to just speak of a death wish, since this offers space to recognize the variety of considerations and circumstances underlying said death wishes.