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The establishment of link between high-risk human papillomavirus (HPV) infection and occurrence of cervical cancer has resulted in development of various HPV related control strategies for the prevention of cervical cancer. The objective of the present study was to assess the cost effectiveness of various screening strategies for cervical cancer and human papilloma virus (HPV) vaccination in India. A Markov model based on societal perspective was designed to estimate the lifetime costs and consequences of screening (with either visual inspect with acetic acid (VIA), Papanicolaou test or HPV DNA test at various time intervals) in a hypothetical cohort of 30-65 years age women or vaccination among adolescent girls. Diagnostic accuracy of the screening strategies, efficacy of HPV vaccination and data on transition probabilities was based on the results of the existing meta-analyses. Primary data was collected for assessing per person cost of screening, cost of treating cervical cancer and quality of life. We fouPV vaccination alone and vaccination plus screening (with VIA every 5 yearly and VIA 10 yearly) appears to be cost effective with ICERs in the range of US$ 86 (INR 5,693) to US$ 476 (INR 31,511) per QALY gained. In the long run, when the cohort of adolescent girls, who were immunized for HPV, reach the age of 30 years, the screening frequency using VIA should be determined based on the coverage of HPV vaccination in that cohort.The proposed method is to do simplification for Digital Elevation Model (DEM), which uses a few of original nodes representing the terrain surface while maintaining the accuracy. The original DEM nodes are sampled using the Maximal Poisson-disk Sampling (MPS), in which, the disk’s size of each sample is computed on basis of the Singular Value Decomposition (SVD). MPS can generate the hyper-uniformly distributed samples and was taken to do DEM adaptive sampling by being combined with the geodesic metric. However, the geodesic distance computation is complex and the requirement for memory is high. As such, this paper proposes an extension of the classic MPS based method for selecting quasi-randomly distributed points from DEM nodes based on the distribution of eigenvalues, accounting for surface heterogeneity. Mepazine To achieve this objective, uniform MPS is conducted to sample the DEM nodes by setting the related disk radius to be inversely proportional to the local terrain complexity, which is defined as an index expressing the local terrain variation. Then, the geodesic metric related parameters are implicitly contained in the defined index. As a result, more samples are concentrated in the rugged regions, and vice versa. The proposed method shows better perfermance, at least the results are comparable with the geodesic distance based Poisson disk sampling method. Meanwhile, it greatly accelerates the sampling process and reduces the memory cost.Gender-wage gaps are an important phenomenon on labor markets. They can possibly be caused by the institutional framework. This question is addressed in this paper. When only joint output can be observed in team production, individuals may submit self-reports of their contribution to a principal. In a multi-employee gift exchange experiment, we study how men and women behave differently with and without such self-reports. We cannot reject that self-reports left the overall efficiency of the gift exchange interaction unchanged, but detect notable gender differences. Women reported similar effort levels as men, but contributed significantly less. The difference in contributions led to a significant gender gap in wages, depending on gender group composition. These effects were only present when participants did not know each other’s gender, however. When instead gender was observable, the behavior of men and women converged. The results suggest that parts of wage gaps may be related to different behavior within incomplete contract and imperfect information environments, depending on details of the informational context.Highly exposed seronegative (HESN) individuals present a unique setting to study mechanisms of protection against HIV acquisition. As natural killer (NK) cell activation and function have been implicated as a correlate of protection in HESN individuals, we sought to better understand the features of NK cells that may confer protection. We used mass cytometry to phenotypically profile NK cells from a cohort of Beninese sex workers and healthy controls. We found that NK cells from HESN women had increased expression of NKG2A, NKp30 and LILRB1, as well as the Fc receptor CD16, and decreased expression of DNAM-1, CD94, Siglec-7, and NKp44. Using functional assessments of NK cells from healthy donors against autologous HIV-infected CD4+ T cells, we observed that NKp30+ and Siglec-7+ cells had improved functional activity. Further, we found that NK cells from HESN women trended towards increased antibody-dependent cellular cytotoxicity (ADCC) activity; this activity correlated with increased CD16 expression. Overall, we identify features of NK cells in HESN women that may contribute to protection from HIV infection. Follow up studies with larger cohorts are warranted to confirm these findings.

Anticoagulation (AC) is a critical topic in perioperative and post-bleeding management. Nevertheless, there is a lack of data about the safe, judicious use of prophylactic and therapeutic anticoagulation with regard to risk factors and the cause and modality of brain tissue damage as well as unfavorable outcomes such as postoperative hemorrhage (PH) and thromboembolic events (TE) in neurosurgical patients. We therefore present retrospective data on perioperative anticoagulation in meningioma surgery.

Data of 286 patients undergoing meningioma surgery between 2006 and 2018 were analyzed. We followed up on anticoagulation management, doses and time points of first application, laboratory values, and adverse events such as PH and TE. Pre-existing medication and hemostatic conditions were evaluated. The time course of patients was measured as overall survival, readmission within 30 days after surgery, as well as Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS). Statistical analysis was performed using multivariate regression.