Activity

, prevalence of diabetes mellitus, COVID-19 disease severity and use of immune modulating agents including the combined use of corticosteroids and immunosuppressive agents in patients with cancer and transplants.

The aim of this study was to evaluate ceftazidime pharmacokinetics (PK) in a cohort that includes a predominate number of children and adolescents with obesity and assess the efficacy of competing dosing strategies.

A population PK model was developed using opportunistically collected plasma samples. For each dosing strategy, model-based probability of target attainment (PTA) estimates were computed for study participants using empirical Bayes estimates. In addition, the effects of body size and renal function on PTA were evaluated using stochastic model simulations with virtually generated subjects.

Twenty-nine participants, 24 of whom were obese, contributed data towards the analysis. The median (range) age, body weight, and body mass index of participants were 12.2 years (2.3-20.6), 59.2 kg (8.4-121), and 25.2kg/m

(13.8-42.9), respectively. Administration of 50mg/kg intravenously (IV) every 8 hours (q8h; max 6g/day) or 40mg/kg IV q6h (max 6g/day) resulted in PTA values of ≥90% (minimum inhibitory concentration 8mg/L) for the subset of obese participants with estimated glomerular filtration rates (GFR) ≥~80mL/min/1.73m

. However, for both regimens, stochastic model simulations denoted lower PTA values (<90%) with increasing body weight forvirtual subjects with GFR ≥120mL/min/1.73m

. Alternatively, permitting for a maximum daily dose of 8g/day using a 40mg/kg IV q6h regimen provided PTA values that were near or above target (90%) forvirtual subjects between 10 to 120kg with GFR ≥80mL/min/1.73m

.

Our analysis suggests administration of 40mg/kg IV q6h (max 8g/day) maximizes PTA in children and adolescents with obesity and GFR ≥80mL/min/1.73m

.

Clinicaltrials.gov Identifier NCT01431326.

Clinicaltrials.gov Identifier NCT01431326.TORCH (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes Simplex Virus and Syphilis) infections are a major cause of intrauterine and perinatal infections with associated morbidity and mortality. Neonatal Herpes Simplex Virus infection caused by an enveloped, double-stranded DNA virus of the Herpesviridae family is devastating and fatal. Herpes Viruses are not hepatotropic but may rarely cause hepatitis. Most cases of HSV hepatitis rapidly progress to fulminant hepatic failure and often fatal before the diagnosis or transplantation. Nowadays, despite the availability of antiviral treatment (acyclovir), the outcome remains poor because of late identification of hepatic Herpes Simplex Virus (HSV) infection. We report a male neonate suspected with a metabolic/mitochondrial disease and multi-organ involvement but who developed a fulminant hepatic failure and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. Leukadherin-1 datasheet The postmortem diagnosis was performed demonstrating HSV-1 in liver tissue by transmission electron microscopy and by retrospective detection of HSV specific antigens by immunohistochemistry.

Using distinct measures for racial microaggressions and discrimination, this article explored the association between discriminatory experiences and self-reported health status among Asian populations in the USA and its subethnic group variation.

This article investigated 4393 Asian American adults from the 2016 Post-Election National Asian American Survey (NAAS). Binary measure of self-reported health (not good/good) was accounted for. Two measures of racial microaggressions included (1) verbal microaggression and (2) behavioral microaggression. Two measures of discrimination encompassed (1) workplace discrimination and (2) institutional racism. Ethic groups were classified to (1) East Asian (n=1491), (2) Southeast Asian (n=1758), or (3) South Asian (n=1144).

Findings from logistic regression analyses showed that increased workplace discrimination and institutional racism yielded decreased odds of reporting good health status. The association between racial microaggressions, discrimination, and self-reported health status varied across ethnic subgroup, indicating that the verbal aggression score was more predictive for the East Asian group while institutional racism was most harmful to Southeast Asians.

Findings highlighted the racialized interpretation and its variations in self-reported health status among Asian populations. Relating to variations in experiences of racialization and attainment of socioeconomic status, disproportionate relationships of discriminatory experiences and health among Asian populations were further discussed.

Findings highlighted the racialized interpretation and its variations in self-reported health status among Asian populations. Relating to variations in experiences of racialization and attainment of socioeconomic status, disproportionate relationships of discriminatory experiences and health among Asian populations were further discussed.With disease-modifying approaches under evaluation in ataxia-telangiectasia and other ataxias, there is a need for objective and reliable biomarkers of free-living motor function. In this study, we test the hypothesis that metrics derived from a single wrist sensor worn at home provide accurate, reliable, and interpretable information about neurological disease severity in children with A-T.A total of 15 children with A-T and 15 age- and sex-matched controls wore a sensor with a triaxial accelerometer on their dominant wrist for 1 week at home. Activity intensity measures, derived from the sensor data, were compared with in-person neurological evaluation on the Brief Ataxia Rating Scale (BARS) and performance on a validated computer mouse task.Children with A-T were inactive the same proportion of each day as controls but produced more low intensity movements (p  less then  0.01; Cohen’s d = 1.48) and fewer high intensity movements (p  less then  0.001; Cohen’s d = 1.71). The range of activity intensities was markedly reduced in A-T compared to controls (p  less then  0.0001; Cohen’s d = 2.72). The activity metrics correlated strongly with arm, gait, and total clinical severity (r 0.71-0.87; p  less then  0.0001), correlated with specific computer task motor features (r 0.67-0.92; p  less then  0.01), demonstrated high reliability (r 0.86-0.93; p  less then  0.00001), and were not significantly influenced by age in the healthy control group.Motor activity metrics from a single, inexpensive wrist sensor during free-living behavior provide accurate and reliable information about diagnosis, neurological disease severity, and motor performance. These low-burden measurements are applicable independent of ambulatory status and are potential digital behavioral biomarkers in A-T.