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48, p = 0.0036), men (χ2 = 17.1, p less then 0.0001), and current and former smokers (χ2 = 19.2, p less then 0.0001). Notably, epidermal growth factor receptor (EGFR) mutation-positive lung cancer patients with high PAK1 expression showed higher mortality rates than those with low PAK1 expression (91.3% vs. 62.5%, p = 0.02). Therefore, PAK1 overexpression could serve as a molecular target for the treatment of EGFR mutation-positive lung cancer, especially among male patients and current/former smokers.

Gender medicine permeates all sectors of medicine, from prevention to treatment and rehabilitation; it aims to customize the care path, ensuring equity in the access to health care system services. It is unclear to what extent physiotherapists’ treatment choices align with gender medicine principles. The aim of this survey is to detect the need of Italian physiotherapists to deepen knowledge in gender medicine.

An 18-item survey assessed the characteristics of responders about knowledge of gender medicine. An online survey was performed in 2020 using SurveyMonkey Software. Data were analyzed by statistical regression.

A total of 617 physiotherapists voluntarily participated in the study (53.84% of the target population). The majority of responders (68.4%) declared having general information about gender medicine, but 55.43% of them claimed to have heard of it but did not know properly what gender medicine was about; 92.38% of the physiotherapists believed that they needed training to acquire knowledge in gender medicine.

Gender equity matters for health. Moderate knowledge of gender medicine’ principles and modest application of these findings were used in clinical practice of physiotherapy. Physiotherapists declared that they need training in gender medicine.

Gender equity matters for health. Moderate knowledge of gender medicine’ principles and modest application of these findings were used in clinical practice of physiotherapy. Physiotherapists declared that they need training in gender medicine.Phosphonated polyanilines were synthesized by copolymerization of aniline (ANI) with both 2- and 4-aminophenylphosphonic acids (APPA). The material composition and the final properties of the copolymers can be easily tailored by controlling the monomers ANI/APPA molar feed ratio. An important influence on the reactivity of monomers has been found with the substituent position in the ring, leading to differences in the properties and size of blocks of each monomer in the polymer. As expected, while 2APPA shows more similarities to ANI, 4APPA is much less reactive. Phosphorus loading of ~5 at% was achieved in the poly(aniline-co-2-aminophenylphosphonic acid) (PANI2APPA) with a 50/50 molar feed ratio. All the resulting copolymers were characterized by different techniques. Experimental results and density functional theory (DFT) computational calculations suggest that the presence of phosphonic groups in the polymeric chain gives rise to inter- and intra-chain interactions, as well as important steric effects, which induce a slight twist in the substituted PANI structure. Therefore, the physicochemical, electrical, and electrochemical properties are modified and can be suitably controlled.This work presents carbon fabric reinforced aluminosilicate matrix composites with content of boric acid, where boron replaces aluminum ions in the matrix and can increase the mechanical properties of composites. Five different amounts of boric acid were added to the alkaline activator for preparing six types (including alkaline activator without boric acid) of composites by the prepreg method. The influence of boric acid content in the matrix on the tensile strength, Young’s modulus and interlaminar strength of composites was studied. Attention was also paid to the influence of boron content on the behavior of the matrix and on the internal structure of composites, which was monitored using a scanning electron microscope. The advantage of the aluminosilicate matrix is its resistance to high temperatures; therefore, tests were also performed on samples affected by temperatures of 400-800 °C. The interlaminar strength obtained by short-beam test were measured on samples exposed to 500 °C either hot (i.e. measured at 500 °C) or cooled down to room temperature. Lithocholic acid purchase The results showed that the addition of boron to the aluminosilicate matrix of the prepared composites did not have any significant effect on their mechanical properties. The presence of boron affected the brittleness and swelling of the matrix and the differences in mechanical properties were evident in samples exposed to temperatures above 500 °C. All six prepared composites showed tensile strength higher than 320 MPa at laboratory temperature. The boron-free composite had the highest strength 385 MPa. All samples showed a tensile strength higher than 230 MPa at elevated temperatures up to 500 °C.Extensive burns result in a local wound response and distant-organ injury (DOI) caused by oxidative-stress and inflammation. Melatonin (MT) shows promise in alleviating oxidative-stress and inflammation, but its role in thermal injury is largely unexplored. The present systematic review and meta-analysis were designed to assess the effects of MT on oxidative-stress and inflammatory markers against severe burn-induced DOI. Mean difference (MD)/standard mean difference (SMD) with 95% confidence interval (CI) were estimated using fixed-effect/random-effects models. Eighteen experimental studies met the inclusion criteria. Compared with the control group, MT significantly decreased the levels of malondialdehyde (SMD, -1.03; 95% CI, -1.30, -0.76, p less then 0.00001) and 4-hydroxynonenal (MD, -1.06; 95% CI, -1.57, -0.56, p less then 0.0001). Additionally, MT increased the levels of glutathione (SMD, 1.94; 95% CI, 1.27, 2.61, p less then 0.00001) and superoxide-dismutase (SMD, 0.76; 95% CI, 0.08, 1.45, p = 0.03). Finally, MT significantly decreased the levels of tumor necrosis factor-α (SMD, -1.34; 95% CI, -1.92 to -0.77; p less then 0.00001) and C-reactive protein (MD, -12.67; 95% CI, -16.72 to -8.62; p less then 0.00001). Meta-analysis indicates that severe burn followed by immediate MT (10 mg/kg) intervention shows significant beneficial effects after 24-h against DOI by regulating oxidative-stress and the inflammatory response.