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ess. It is opportune to further investigate AI in OCSG for early psychological intervention as an adjunct to conventional intervention programs.RATIONALE, AIMS AND OBJECTIVES In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD. This study aims to analyze the association between the continuous use of omeprazole and the progression of CKD in adult and elderly individuals. METHOD A retrospective cohort study was conducted with patients followed up at a nephrology clinic in Brazil, in 2016 and 2017. Information about clinical and sociodemographic data, health behaviors, and medication use were collected from all patients diagnosed with CKD through consultation of medical charts and the Brazilian health information system (SIS). The participants were allocated into two groups users and non-users of omeprazole, and the progression of CKD was then evaluated for each group. In the bivariate analysis, the Mann-Whitney U test to compare the quantitative variables between groups, and the Pearson/Fisher two-tailed chi-square test to compare the categorical variables were applied. Multivariate analysis was performed using Cox regression. RESULTS A total of 199 CKD patients were attended in the polyclinic, and of these, 42.7% were omeprazole users. There was a higher percentage of CKD progression in users (70.6%) compared to non-users (10.5%). The hazard ratio was 7.34 (CI 3.94-13.71), indicating a higher risk of progression to worse stages of CKD in omeprazole users than in non-users. As for the other variables, no statistically significant difference was found between groups (p > 0.05). CONCLUSION An association between omeprazole use and progression of CKD stage was identified, showing a higher risk of disease evolution among omeprazole users.To effectively reduce traffic violations that often cause severe crashes at signalized intersections, exploring their contributing factors seems hugely urgent and essential. This study attempted to investigate the influence factors of wrong-way driving (WWD), red-light-running (RLR), violating traffic markings (VTM), and driving in the inaccurate oriented lane (DIOL) at signalized intersections by using data collected from traffic enforcement camera in Hohhot, China. To this end, an ordinary multinomial logit model was developed. By considering the unobserved heterogeneity between observations, a random effects multinomial logit model was proposed as well. After that, the marginal effects of explanatory variables were computed. The outcomes showed that non-local vehicles were more likely to commit WWD and VTM than local vehicles. WWD and RLR frequently occurred in the daytime and evening (600-2359), and on most days within a week. RLR and DIOL mainly happened in June and July. The left-turn lane ratio significantly increased RLR and DIOL. BAY-61-3606 The cloudy, partly cloudy, and rainy days obviously increased WWD and VTM. The temperature from 21 to 30 degrees centigrade was apparently associated with the higher likelihoods of RLR and DIOL. According to the findings of this study, some intervention measures, targeting different vehicle types and considering temporal factors, road, and weather conditions, were recommended to reduce WWD, RLR, VTM, and DIOL at signalized intersections.The Kura-Araxes cultural tradition (ca. 3500-2200 BCE) was one of the most widespread archaeological horizons in Southwest Asian prehistory, spanning from the Caucasus to the southern Levant. Although several decades of research have considerably increased our knowledge about this Early Bronze Age tradition, the social and economic organization of its communities remains a matter of much debate. Interpretations of the organization of Kura-Araxes craft economies range from need-based household production to extra-household specialized production for exchange and elite consumption. This issue stems from the absence of a systematic approach to studying the spatial organization of craft production; that is the study of the spatial distribution of archaeological material across multiple contexts to reconstruct the location of various activities involved in craft production. Extensive evidence for craft production at Köhne Shahar (KSH)-one of the largest Kura-Araxes sites ever discovered-provides an opportunity for strict social hierarchy at KSH and across the Kura-Araxes world is not evidence of the absence of social complexity, but the presence of a horizontal or heterarchical social order.BACKGROUND More than 80% of premature deaths due to cardiovascular disease (CVD) occur in low- and middle-income countries. However, access to, and affordability of medications remain a challenge in these countries. OBJECTIVE To assess the availability, cost and affordability of essential cardiovascular medicines in the South West region of Cameroon. METHODS In an audit of 63 medicine outlets, twenty-six essential medicines were surveyed using the World Health Organisation (WHO) /Health Action International methodology. Availability, costs and the ratio of the median price to the international reference price were evaluated in public, confessional, private facility medicine outlets, and community pharmacies. Affordability was assessed by calculating the number of days’ wages it will cost the lowest-paid unskilled government worker to purchase a month worth of chronic treatment. FINDINGS Availability ranged from 25.3% (public facility outlets) to 49.2% (community pharmacies) for all medicines. This was higher in urban and semi-urban compared to rural outlets. Cost of medicines was highest in community pharmacies and lowest in public facility outlets. Aspirin, digoxin, furosemide, hydrochlorothiazide and nifedipine were affordable (cost a day’s wage or less). Medicines for heart failure and dyslipidaemia (beta blockers, angiotensin converting enzyme inhibitors and statins) required 2-5 days and 6-13 days wages respectively for one month of chronic treatment. CONCLUSION Overall availability of CVD essential medicines was lower than WHO recommendations, and medicines were largely unaffordable. While primary prevention is pivotal, improving availability and affordability of medicines especially for public facilities would provide additional benefit in curbing the CVD burden.