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Assessment of three-dimensional (3D) femorotibial alignment is essential for successful knee osteoarthritis treatment in the elderly. The complex morphology of the posterior tibial slope (PTS) might have an influence on sagittal and rotational alignment and the positional relationship between the femur and tibia in the anterior-posterior (AP) direction under weight-bearing conditions.

This study aimed to clarify the association between the PTS and 3D femorotibial alignment under weight-bearing conditions in healthy Japanese elderly individuals.

We investigated the 3D femorotibial alignment of 110 lower extremities of 55 healthy individuals (26 women, 29 men, mean age 70 ±6 years). Using our previously reported 3D-to-2D image registration technique, we evaluated the 3D hip-knee-ankle angle (3DHKA) in the sagittal plane, rotational alignment, and the distance between the femoral and tibial origins in the AP direction (tibial AP position) as femorotibial alignment parameters under weight-bearing conditions. We assessed the medial and lateral PTS and their angular difference (PTS difference) as PTS parameters. Stepwise multiple linear regression analysis was performed using PTS parameters and other possible confounders (age, sex, height, and weight) as the independent variables and femorotibial alignment parameters as the dependent variable.

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With inherent flexibility, high electroconductivity, excellent thermal conductivity, easy printability and biosafety, Ga-based functional liquid metals (LMs) have been extensively evaluated for biomedical applications. When implanted in the biological environment, the safety of the LMs is a major concern for future application.

In this study, we conducted several biocompatibility assessments through immersion experiments, invitro cytotoxicity experiments and invivo embedding experiments.

The results showed that both the Al-assisted self-driven LM and the LM per se own good biocompatibility and retrievable properties when contacted with living organisms for a relatively long period of time.

This study provides preliminary evidence about the biocompatibility of the functional LM materials, such as LM-based soft machine, which would promote and inspire other research to address other tough biomedical issues.

This study provides preliminary evidence about the biocompatibility of the functional LM materials, such as LM-based soft machine, which would promote and inspire other research to address other tough biomedical issues.

The post-cam mechanism in the posterior-stabilized (PS) implant plays an important role, such as durability and kinematic performances, in total knee arthroplasty (TKA).

The purpose of this study was to evaluate the difference in the kinematics and contact stress of five post-cam designs, which are flat-and-flat, curve-and-curve (concave), curve-and-curve (concave and convex), helical, and asymmetrical post-cam designs, using three-dimensional finite element models.

We designed the post-cam model with five different geometries. The kinematics, contact stress, and contact area were evaluated in the five post-cam designs under gait cycle loading conditions using the finite element method.

There were no differences in the contact stress and area on the tibial insert in all designs. The largest internal rotation was shown in the swing phase for the helical design, and the largest tibial posterior translation was observed for the curve-and-curve (concave) design. 1-Azakenpaullone solubility dmso The curve-and-curve (concave) design showed the lowest contact stress and the largest posterior tibial translation during the gait cycle.

Considering the kinematics and contact stress, we found that the curve-and-curve (concave) design was more stable than other designs. From the results, we found the important factors of TKA implant considering stability and kinematics.

Considering the kinematics and contact stress, we found that the curve-and-curve (concave) design was more stable than other designs. From the results, we found the important factors of TKA implant considering stability and kinematics.Stem cells play critical roles in tissue repair and regeneration. The construction of stem cell-derived microtissue is a promising strategy for transplanting cells into defects to improve tissue regeneration efficiency. However, rapidly constructing larger microtissues and promoting vascularization to ensure the cellular nutrient supply remain major challenges. Here, we have developed a magnetic device to rapidly construct and regulate millimeter-scale microtissues derived from magnetic nanoparticle-labeled cells. When the microtissue was cultured under a specific magnetic field, the shape of the microtissue could be changed. Importantly, cell proliferation was maintained, and angiogenesis was activated in the process of microtissue deformation. We developed a magnetic control method to treat microtissue, and the implanted microtissue showed excellent vascularizationin vivo. In brief, this magnetic control technology provides a promising strategy for vascularized regenerative medicine.Bisphenol A is a chemical used primarily as a monomer in the production of polycarbonate plastics and epoxy resins. It is a synthetic chemical compound that is produced in billions of pounds annually, and tagged as an endocrine disruptor. Bisphenol A is a high production synthetic chemical compound that is used in the production of many consumables and equipments of daily consumption and use by man. Growing interest in possible health threats posed by endocrine disrupting chemicals (bisphenol-A inclusive), as these substances are in our environment, food, and many consumer products. Therefore, this study aims to determine bisphenol-A effects on the hypothalamo-pituitary-ovarian axis, and role of melatonin in this regard. Forty-two Wistar rats were bred, grouped into 7, with each group consisting of 6 rats. Experimental groups were administered low and high doses of bisphenol-A and melatonin, starting from day 19, and was continued for 7 weeks orally. They were left to develop into full adults and were sacrificed on day 120±4 days. Blood samples, hypothalamus, pituitary and ovarian tissues were excised for biochemical and tissue antioxidants assays as well as genetic studies. Results show elevated gonadotropin and androgen levels. There was disruption of reactive oxygen species in the ovarian tissues, as well as alterations in the expression of genes that regulate reproduction at the hypothalamus and pituitary levels. Conclusion of early exposure to bisphenol-A is associated with prolonged duration of disruption of reproductive functions in female Wistar rats, which persist long after cessation of the exposure. Melatonin antioxidant effects give some promising outturns against bisphenol-A induced toxicities.