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Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multifaceted syndrome with a variable phenotype. Few studies have described the associated dental characteristics and their relationship with medical co-morbidities; and no Australian data exist.

To determine the clinical manifestations and correlations between oral and medical conditions in children with 22q11.2DS.

A retrospective observational study. Children genetically diagnosed with 22q11.2DS at the Royal Children’s Hospital Melbourne were selected; their medical and dental characteristics were collated and analysed.

The study population (n=57; mean age 11.5years, range 2-27years) experienced a range of medical conditions involving multiple medical systems; of whom 44 (77.2%) had caries experience, 7 (12.3%) developmentally missing teeth, and 31 (54.4%) developmental defects of enamel (DDE). Z-VAD(OMe)-FMK Smaller proportions of primary teeth were affected by DDE in children with congenital heart disease (2.2% vs 9.7%; P=.02), and cardiac surgery (0.2% vs 9%; P=.001). Conversely, children with hypoparathyroidism (n=2) had significantly higher proportions of primary teeth affected by DDE (27.5% vs 4%; P=.02).

Significant associations existed between medical conditions (congenital heart disease, history of cardiac surgery, and hypoparathyroidism) and primary dentition DDE in children with 22q11.2 DS.

Significant associations existed between medical conditions (congenital heart disease, history of cardiac surgery, and hypoparathyroidism) and primary dentition DDE in children with 22q11.2 DS.Pyruvate and creatine, energetics and antioxidant substances, can promote rumen fermentation and metabolism. This study aimed to evaluate the stress resistance and rumen fermentation effects of the compound creatine pyruvate (CrPyr) in diets for beef cattle under heat stress. Four Jinjiang steers fitted with permanent rumen cannulas were used in a 4 × 4 Latin square design and fed a diet supplemented with CrPyr at 0, 20, 40, or 60 g/d. Heat stress was employed for 62 of 64 days. Supplementing with CrPyr elevated their levels of free triiodothyronine and triiodothyronine, superoxide dismutase activity, ruminal pH value, microbial crude protein concentration, crude fat digestibility, nitrogen intake, and levels of urine allantoin and total purine derivatives. It also reduced their levels of cortisol and corticosterone, malondialdehyde concentration, lactate dehydrogenase activity, and urine nitrogen excretion. In conclusion, CrPyr relieves the heat stress of beef cattle by improving antioxidant activity and rumen microbial protein synthesis.Cancer develops through multiple rounds of clonal evolution of cells with abrogated defense systems. Such clonal evolution is triggered by genomic destabilization with associated mutagenesis. However, what increases the risk of genomic destabilization remains unclear. Genomic instability is usually the result of erroneous repair of DNA double-strand breaks (DSB); paradoxically, however, most cancers develop with genomic instability but lack mutations in DNA repair systems. In this manuscript, we review current knowledge regarding a cellular state that increases the risk of genomic destabilization, in which cells exhibit phenotypes often observed during senescence. In addition, we explore the pathways that lead to genomic destabilization and its associated mutagenesis, which ultimately result in cancer.The purpose of this study was to evaluate the smallest detectable change (SDC), minimally important change (MIC), and factor structure of the Oslo Sports Trauma Research Center (OSTRC) questionnaire severity score in half- and full-marathon runners. Data came from a prospective cohort study, the SUcces Measurement and Monitoring Utrecht Marathon (SUMMUM) 2017 study. Two external anchors, the global rating of change (GRC) and global rating of limitations (GRL), were used to classify the running-related injuries (RRI) as truly improved, unchanged, or truly worsened. SDC values were calculated at individual and group levels. MIC values were calculated using the visual anchor-based MIC distribution and mean change methods. Confirmatory factor analysis (CFA) was used to study the a priori hypothesized factor structure. A total of 132 runners who reported the same RRI on two occasions 2 weeks apart were included in the analysis. SDC values at individual and group levels were ≤35.06 and ≤9.30, respectively. With the visual anchor-based MIC distribution method, the MIC values for RRIs that truly improved according to the GRC and GRL anchors were 13.50 and 18.50, respectively. With the mean change method, the MIC values for RRIs that truly improved according to the GRC and GRL anchors were 15.49 and 45.38, respectively. The CFA confirmed that the OSTRC was a unidimensional questionnaire. The change score of the OSTRC severity score can be used to distinguish between important change and measurement error at a group level using the MIC value 18.50. Because the SDC of the OSTRC severity score was larger than the MIC, it is not advised to use the MIC at an individual level.Coral bleaching is the single largest global threat to coral reefs worldwide. Integrating the diverse body of work on coral bleaching is critical to understanding and combating this global problem. Yet investigating the drivers, patterns, and processes of coral bleaching poses a major challenge. A recent review of published experiments revealed a wide range of experimental variables used across studies. Such a wide range of approaches enhances discovery, but without full transparency in the experimental and analytical methods used, can also make comparisons among studies challenging. To increase comparability but not stifle innovation, we propose a common framework for coral bleaching experiments that includes consideration of coral provenance, experimental conditions, and husbandry. For example, reporting the number of genets used, collection site conditions, the experimental temperature offset(s) from the maximum monthly mean (MMM) of the collection site, experimental light conditions, flow, and the feeding regime will greatly facilitate comparability across studies.