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There is a growing in te rest in the possible association between perfectionism and suicide. Smith and colleagues (2018) gave an up-to-date overview on this topic in a meta-analysis including quantitative studies and found that perfectionism disp la yed positive associations with suicide ideation and attempts. The current article’s purpose was to conduct a systematic review on this topic, focusing on studies with qualitative research method.

A systematic literature search was conducted on four databases (PsychInfo, PubMed, Ovid MEDLINE, Web of Science) with the following keywords (*perfectionism or self-criticism) and (suicide* or suicidality*). Inclusion criteria were peer-reviewed journals and publications written in Eng lish and qualitative methodology. Exclusion criteria were the absence of empirical data.

Altogether eight articles were identified, which met the inclusion criteria. All studies found strong correlation between perfectionism and suicidal behaviour. We also differentiated the studies using clinical or community sample and found the same, that perfectionism strongly connects to suicidal behaviour in both groups.

This review of studies using qualitative research method supports those previous studies with quantitative method, which suggest that perfectionism can play an important role in suicidal behaviour.

This review of studies using qualitative research method supports those previous studies with quantitative method, which suggest that perfectionism can play an important role in suicidal behaviour.All intracellular pathogens must escape (egress) from the confines of their host cell to disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole or in a cyst, and must undergo egress at four distinct phases during its complex life cycle, each time disrupting, in a highly regulated manner, the membranes or cyst wall that entrap the parasites. This Cell Science at a Glance article and accompanying poster summarises our current knowledge of the morphological features of egress across the Plasmodium life cycle, the molecular mechanisms that govern the process, and how researchers are working to exploit this knowledge to develop much-needed new approaches to malaria control.

To determine whether increased patient interaction, exposure to the neurologic examination, and access to positive neurology mentors increase interest in neurology for first-year medical students.

Neuro Day was a 2-part experience for first-year medical students. The first part consisted of a flipped classroom to teach the standard neurologic examination. The second part involved patient encounters modeled off of the traditional patient rounds. Students rotated from room to room, listening to patients’ experiences with different neurologic diseases and eliciting pathologic neurologic examinations. Students were surveyed before and after Neuro Day.

The result of the binomial test indicated that the proportion of medical students interested in neurology significantly increased from 78% to 85% (95% confidence interval [CI] 0.79-0.92;

= 0.034) after participating in Neuro Day. The proportion of students’ knowledge of clinical neurology increased from 45% to 63.1% (95% CI 0.54-0.72;

< 0.0001), comfort with performing a neurologic examination increased from 30% to 78.4% (95% CI 0.70-0.86;

< 0.0001), and fear of studying neurology decreased from 46% to 26% (95% CI 0.17-0.34;

< 0.0001) following Neuro Day. One hundred percent of students indicated that they would recommend Neuro Day to their peers.

Neuro Day is a feasible and effective model to incorporate into medical education. There was increased interest in and decreased fear of neurology. We anticipate that this paradigm can be used in the future to encourage students to consider a career in neurology.

Neuro Day is a feasible and effective model to incorporate into medical education. There was increased interest in and decreased fear of neurology. We anticipate that this paradigm can be used in the future to encourage students to consider a career in neurology.

Pathogenic germline variants in

ransient

eceptor

otential

anilloid 4

ation

hannel (

) lead to channelopathies, which are phenotypically diverse and heterogeneous disorders grossly divided in neuromuscular disorders and skeletal dysplasia. We recently reported in sporadic giant cell lesions of the jaws (GCLJs) novel, somatic, heterozygous, gain-of-function mutations in

, at Met713.

Here we report two unrelated women with a de novo germline p.Leu619Pro

variant and an overlapping systemic disorder affecting all organs individually described in TRPV4 channelopathies.

From an early age, both patients had several lesions of the nervous system including progressive polyneuropathy, and multiple aggressive giant cell-rich lesions of the jaws and craniofacial/skull bones, and other skeletal lesions. One patient had a relatively milder disease phenotype possibly due to postzygotic somatic mosaicism. Indeed, the

p.Leu619Pro variant was present at a lower frequency (variant allele frequency (VAFf TRPV4 mutations on different organ systems leading to complex phenotypes which are further mitigated by possible post-zygotic mosaicism. Pemrametostat cell line Treatment of this disorder is challenging, and surgical intervention of the GCLJ worsens the lesions, suggesting the future use of MEK inhibitors and TRPV4 antagonists as therapeutic modalities for unmet clinical needs.As the Moderna (mRNA-1273) and Pfizer/BioNTech (BNT162b2) vaccines become available to patients with autoimmune diseases and SLE, practitioners will have to inform them about the safety and efficacy of these vaccines. Here we discuss the challenges of applying vaccine data to patients with autoimmune diseases and the evidence available in the literature that may help in the decision process.

Women with SLE face an increased risk of adverse pregnancy outcomes compared with healthy women, but the underlying immunological mechanisms are unknown. Given the recognised association of neutrophil activation with SLE pathogenesis, we examined whether there is increased neutrophil activation and inflammation in blood and placenta in SLE relative to healthy pregnancy.

At delivery, peripheral blood, maternal-derived intervillous blood and placentas were collected from 12 SLE and 10 healthy control pregnancies. The proportion of low-density granulocytes (LDGs) and the activation status of LDG and normal-density granulocytes were examined with flow cytometry. The chemokines CXCL8 and CXCL1 were quantified with a cytometric bead-based assay and interferon alpha (IFNα) protein levels with a Simoa method. IFNα-stimulated maternal-derived decidual stromal cells were examined for

gene expression with qPCR. A pathologist, blinded to the patient background, examined all placentas.

Women with SLE had significantly higher proportions of LDG in peripheral blood compared with controls (p=0.