Steen

Self-assembly of the amyloid-β (Aβ) peptide into aggregates, from small oligomers to amyloid fibrils, is fundamentally linked with Alzheimer’s disease (AD). However, it is clear that not all forms of Aβ are equally harmful and that linking a specific aggregate to toxicity also depends on the assays and model systems used (Haass et al., J Biol. Ch…[Read more]

05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows 178.45 µmol/L…[Read more]

The results indicate that our method is among the most successful ones within our comparison, providing high-quality initial active orbitals very close to the finally optimized (DMRG-)CASSCF orbitals. The method proposed here is expected to greatly benefit the practical implementation of large active space ground-state MR calculations, for…[Read more]

This review will outline the development of all the sensors used for rate adaptive pacing.

The Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event (TRANSITION) and PIONEER-HF trials have shown that sacubitril/valsartan can be initiated early and safely in patients with heart…[Read more]

248 in vol. 6, PMID 32782985.][This corrects the article on p. 249 in vol. 6, PMID 32782986.][This corrects the article on p. 188 in vol. 6, PMID 32782983.][This corrects the article on p. 273 in vol. 6, PMID 32782994.][This corrects the article on p. 259 in vol. 6, PMID 32782989.][This corrects the article on p. 260 in vol. 6, PMID…[Read more]

Likewise, viability was maintained, but a significant decrease was observed after exposure to the highest concentration (p less then 0.001), associated with cell death by late apoptosis and necrosis. When cell cultures were exposed to AH26®, metabolic activity was highly compromised, resulting in cell death. An imbalance in the production of…[Read more]

Everolimus is a mTOR inhibitor which demonstrates clinical activity in several solid tumors, especially in kidney cancer after first line TKI anti VEGF treatment and in breast cancer in association with exemesthane after failure of aroamatase inhibitors. The purpose of this study was to analyze in clinical practice the tolerance of everolimus in…[Read more]