Temple

A triethylamine-promoted domino reaction of three molecular 1,3-indanediones with various 3-methyleneoxindoles in refluxing ethanol has been developed. Series of novel polycyclic triindanone-fused spiro[bicyclo[2.2.2]octane-2,3′-indoline] derivatives were successfully synthesized in satisfactory yields with high diastereoselectivity. This domino…[Read more]

Why put people who are not at risk for the microvascular complications of diabetes on a drug (possibly for the rest of their lives) that has no immediate advantage except to lower subdiabetes glycemia to even lower levels? Rather, individuals at the highest risk for developing diabetes-i.e., those with FPG concentrations of 110-125 mg/dL (6.1-6.9…[Read more]

earing protective devices, such as helmets, to reduce the risk of injuries to the craniofacial region.In an age of expanded genetic screening, fragile X syndrome is increasingly considered a candidate condition, given its prevalence, the absence of curative interventions, and its impact on families. However, relatively little research has explored…[Read more]

This systematic review and meta-analysis will provide a detailed summary of the current evidence related to the efficacy of SHD in treating uterine bleeding after early medical abortion, REGISTRATION NUMBER PROSPERO CRD42020184465.

Ocular benign fibrous histiocytoma can involve corneoscleral limbus and adjacent cornea and usually has a good…[Read more]

Thus, signaling by CXCR4 causes immune suppression in human pancreatic ductal adenocarcinoma and colorectal cancer by impairing the function of the chemokine receptors that mediate the intratumoral accumulation of immune cells.CHD7 encodes an ATP-dependent chromatin remodeling factor. Fluorescein-5-isothiocyanate Mutation of this gene causes…[Read more]