Dougherty

48, p = 0.0036), men (χ2 = 17.1, p less then 0.0001), and current and former smokers (χ2 = 19.2, p less then 0.0001). Notably, epidermal growth factor receptor (EGFR) mutation-positive lung cancer patients with high PAK1 expression showed higher mortality rates than those with low PAK1 expression (91.3% vs. 62.5%, p = 0.02). Therefore, PAK1 o…[Read more]

depressive symptoms at t

(β=-.11; P=.02), but web-based message production at t

did not impact t

depressive symptoms (β=.12; P=.34). Web-based message consumption had a larger effect (β=-.11; P=.02) than offline support networks (β=-.08; P=.03) in reducing older adults’ depressive symptoms over time. Higher baseline depressive sym…[Read more]

Death’s legal definition must be responsive to advances in technology, and it must delineate between life and death. But where to draw the line is difficult to determine. Death’s current legal definition requires irreversible cessation of cardiorespiratory function or irreversible cessation of all brain function. But technology can often restore…[Read more]

Testing used in screening, diagnosis and follow-up of COVID-19 has been a subject of debate. Several organisations have developed formal advice about testing for COVID-19 to assist in the control of the disease. We collated, delineated and appraised current worldwide recommendations about the role and applications of tests to control…[Read more]

A Correction to this paper has been published https//doi.org/10.1038/s41467-020-20152-w.Acridone based synthetic and natural products with inherent anticancer activity advancing the research and generating a large number of structurally diversified compounds. In this sequence we have designed, synthesized a series of tetracyclic acridones with…[Read more]