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Flaviviruses constitute a public health concern because of their global burden and the lack of specific antiviral treatment. Here we investigated the antiviral activity of the alkaloid anisomycin against dengue (DENV) and Zika (ZIKV) viruses. At non-cytotoxic concentrations, anisomycin strongly inhibited the replication of reference strains and…[Read more]

Society of North America, Inc.Purpose To develop a multichannel deep neural network (mcDNN) classification model based on multiscale brain functional connectome data and demonstrate the value of this model by using attention deficit hyperactivity disorder (ADHD) detection as an example. Materials and Methods In this retrospective case-control…[Read more]

Moreover, we calculated the limits of the controllable parameters within which the switching between optical multistability and bistability can occur. We show that our proposed hybrid plasmonic system can be useful for efficient all-optical switches and logic-gate elements for quantum computing and quantum information processing.The positive…[Read more]

haracteristics such as body-type or goals), and mode of delivery (e.g., through organized sports, and leveraging competition to drive healthy behaviours).This paper examines the evolution of the geographic concentration of the Brazilian air transport network with a focus on its determinants and possible detachments from the spatial patterns of…[Read more]

n a one-size-fits-all approach.

The administration of medication or fluids via the intravenous route is a common intervention for many hospital inpatients. However, little research has explored the safety and quality of intravenous therapy from the patient’s perspective, despite the role of the patient in patient safety receiving increased…[Read more]

Detection of protein-binding analytes is important for many applications. Currently, various instrument-based techniques are used for detecting protein-binding analytes. However, such techniques have several limitations including high cost and time-consuming sample processing. In order to overcome these limitations, we developed a sensitive…[Read more]