Dalrymple

Careful consideration of radiotherapy can determine the success of reconstructive therapy. There is a broad spectrum of radiotherapy modalities, both benign and malignant. Delivery mechanisms differ in the physical design, setup, radiation source, administrable dosage, and mode of delivery. This range of options allows radiation oncologists to…[Read more]

Migration is one of the most politically pressing issues of the 21st century but migrant health remains an under-researched area. The International Collaboration for Participatory Health Research (ICPHR) working group on migration developed this position statement to address opportunities and challenges in relation to migrant health. It aims to…[Read more]

Immunity is governed by successful T cell migration, optimized to enable a T cell to fully scan its environment without wasted movement by balancing speed and turning. Here we report that the Arhgef6 RhoGEF (aka alpha-PIX; αPIX; Cool-2), an activator of small GTPases, is required to restrain cell migration speed and cell turning during…[Read more]

75, 95% confidence interval (CI) 1.44-2.14, p<0.001) and LOS (OR 1.07, 95%CI 1.03-1.11) were independently associated with a poor functional outcome. In the mediation analysis, the NIHSS (β=0.137, p<0.001) and LOS (β=0.09, p<0.004) were significant mediators between pre-stroke frailty status and poor functional outcome.

The relationship b…[Read more]

We further demonstrate that PMN-MDSCs are especially expanded in patients with active pemphigus, but not in patients in remission. Moreover, MDSC frequencies correlate with an increased Th2/Th1 cell ratio. In conclusion, the identification of a functional PMN-MDSC population suggests a possible role of these cells as regulators of Th cell…[Read more]

Background Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to endurance training has several limitations in…[Read more]

A quadratic calibration was obtained for plasma (total and unbound), RRTE and CSF over the concentration range of 1-200mg/L for ceftolozane and 0.5-100mg/L for tazobactam, and for urine the concentration range of 10-2,000mg/L for ceftolozane and 5-1,000mg/L for tazobactam. For both ceftolozane and tazobactam, validation testing for matrix effects,…[Read more]

There was no statistically significant difference in the two groups with regard to the age range, gender, diagnosis, side of fracture, and accompanying fractures. Occlusal instability, wound dehiscence, and facial nerve paralysis was found in both the groups. Group 1 had 1 patient which required implant removal due to screw loosing, whereas group…[Read more]

Tisagenlecleucel, an anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy, has demonstrated durable efficacy and a manageable safety profile in pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) in the ELIANA pivotal trial and real-world experience. Experience from investigator-led studies…[Read more]

Therefore, a better understanding of neutrophil granules and their cargoes will not only shed light on their diverse role in cancer but will also reveal them as novel therapeutic targets. This review provides an overview on existing knowledge of neutrophil granules and detailed insight into the pathological relevance of their cargoes in cancer. In…[Read more]

Diaries are written for patients in intensive care units by staff and relatives, especially when patients experience a disorder of their consciousness, such as delirium. Diary entries are written in common language, describing the situation of the patient. The diary can be read by the patient and the family and support the coping and understanding…[Read more]

In this study, the effects of omega-3 fatty acids on egg production, nutrients digestibility, eggs yolk lipid peroxidation, and intestinal morphology in laying hens under physiological stress were investigated. Ninety-six 35-wk-old Lohmann LSL-Lite laying hens were used in 2 × 3 factorial arrangement with 2 levels of dexamethasone (DEX) (0 and…[Read more]

To evaluate the relationship of novel inflammatory markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with retinopathy of prematurity (ROP) development and requirement for laser photocoagulation (LP) treatment.

The charts of infants screened for ROP were reviewed retrospectively, and 120 newborns who had…[Read more]