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Carbon nanotube yarns (CNTYs) possess low density, high conductivity, high strength, and moderate flexibility. These intrinsic properties allow them to be a preferred choice for use as conductive elements in high-performance composites. To fully exploit their potential as conductive reinforcing elements, further improvement in their electrical conductivity is needed. This study demonstrates that tensile cyclic loading under ambient conditions improves the electrical conductivity of two types of CNTYs. The results showed that the electrical resistance of untreated CNTYs was reduced by 80% using cyclic loading, reaching the resistance value of the drawn acid-treated CNTYs. Scanning electron microscopy showed that cyclic loading caused orientation and compaction of the CNT bundles that make up the CNTYs, resulting in significantly improved electrical conductivity of the CNTYs. Furthermore, the elastic modulus was increased by 20% while preserving the tensile strength. This approach has the potential to replace the environmentally unfriendly acid treatment currently used to enhance the conductivity of CNTYs.

To examine health outcomes associated with adherence to Healthcare Effectiveness Data and Information Set (HEDIS) antidepressant medication management (AMM) during acute and continuation phases of depression treatment among older adults with dementia and major depressive disorder (MDD).

Retrospective cohort study.

Medicare 5% sample data (2011-2013).

Older adults (aged 65 years or older) with dementia and MDD.

The first antidepressant prescription claim from 1 May 2011 through 30 April 2012 was considered the index prescription start date (IPSD). Adherence during acute- and continuation-phase AMM was based on HEDIS guidelines. Study outcomes included all-cause mortality, all-cause hospitalization, and falls/factures (with mortality being the competing event for hospitalization and falls/fractures) during follow-up from end of acute-/continuation-phase AMM adherence. Due to the proportionality assumption violation of Cox models, fully non-parametric approaches (Kaplan-Meier and modified Gray’s test) were used for time-to-event analysis adjusting for the inverse probability of treatment weights.

Final study samples consisted of 4330 (adherent (N) = 3114 (71.92%)) and 3941 (adherent (N) = 2407 (61.08%)) older adults with dementia and MDD during acute- and continuation-phase treatments, respectively. No significant difference (

> 0.05) between adherent and non-adherent groups was observed for all-cause mortality and falls/fractures in both the acute and continuation phases. click here There was a significant difference in time to all-cause hospitalization during acute-phase treatment (

= 0.018), with median times of 530 (95% CI 499-587) and 425 (95% CI 364-492) days for adherent and non-adherent groups, respectively.

Acute-phase adherence to HEDIS AMM was associated with reductions in all-cause hospitalization risk among older adults with dementia and MDD.

Acute-phase adherence to HEDIS AMM was associated with reductions in all-cause hospitalization risk among older adults with dementia and MDD.Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating polyomavirus entry are poorly understood. Through genetic knockdown approaches, we identified phosphoinositide 3′-kinase γ (PI3Kγ) and its regulatory subunit PIK3R5 as cellular proteins that facilitate infection of human SVG-A glial cells by JCPyV. PI3Kα appears less important for polyomavirus infection than PI3Kγ. CRISPR/Cas9-mediated knockout of PIK3R5 or PI3Kγ inhibited infection by authentic JCPyV and by JC pseudovirus. PI3Kγ knockout also inhibited infection by BK and Merkel Cell pseudoviruses, other pathogenic human polyomaviruses, and SV40, an important model polyomavirus. Reintroduction of the wild-type PI3Kγ gene into the PI3Kγ knock-out SVG-A cells rescued the JCPyV infection defect. Disruption of the PI3Kγ pathway did not block binding of JCPyV to cells or virus internalization, implying that PI3Kγ facilitates some intracellular step(s) of infection. These results imply that agents that inhibit PI3Kγ signaling may have a role in managing polyomavirus infections.Energy-absorbing lanyards (EAL) are part of fall arrest systems (FAS), their main mission is to dissipate the energy generated during the fall, ensuring that the arresting force does not cause injury to the user. For the design of FAS as set out in the American standard Z359.6 and the Canadian Z259.16 it is essential to know the deployment force or average arrest force (Fa). Fa is necessary to estimate the elongation that the absorber will suffer during the fall and therefore essential data to calculate the clearance distance. There is a lack of useful experimental data for the design of this personal protective equipment (PPE). This work provides empirical data required for the design of FAS with EAL in accordance with EN 355. This paper covers different types of EAL that are marketed internationally; different empirical data, average and maximum forces, required for improving safety design are researched. Six manufacturers, 10 models, and 2 samples of each model were selected, with total of 20 tests being performed. Dynamic performance tests were carried out, the free fall of a person was simulated using a 100 kg steel ballast from the maximum height allowed by the equipment, obtaining the maximum arrest force (Fm), average deployment force (Fa), and, by calculating the balance of forces, the maximum and average acceleration suffered by the ballast during its arrest. In light of the results, relevant conclusions for user safety are obtained. It is feasible to raise the safety requirements established by the different standards. The Fm can be established below 6 kN in the EAL, and the Fa can be estimated at 87.5% of the Fm. The categorization of the force-time curve in fall arrest with EAL has been obtained. Two EAL purchased on the market exceed the Fm permitted, therefore it is recommended to increase the quality controls of EAL.