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Larkinella sp. strain BK230, a heterotrophic bacterium of the phylum Bacteroidetes, was isolated from the roots of a field-grown eastern cottonwood tree (Populus deltoides) located in Georgia. The draft 7.27-Mb genome has a G+C content of 53.4% and contains 6,026 coding sequences, including 41 tRNA genes. Copyright © 2020 Pelletier et al.We report three metagenome-assembled genomes (MAGs) of Planktomarina strains from coastal seawater (Portugal) to help illuminate the functions of understudied Rhodobacteraceae bacteria in marine environments. The MAGs encode proteins involved in aerobic anoxygenic photosynthesis and a versatile carbohydrate metabolism, strengthening the role of Planktomarina species in oceanic carbon cycling. Copyright © 2020 Marques et al.Diverse Shiga toxin-producing Escherichia coli (STEC) strains have been isolated from several environmental samples. Rivers are associated with the distribution of STEC pathogens in the environment. Thus, we report the complete genome sequence of a locus of enterocyte effacement (LEE)-positive STEC O157H7 strain isolated from the Mississippi River.Stenotrophomonas maltophilia is a nosocomial pathogen that primarily causes respiratory infection in humans. This pathogen is widely distributed in the environment, including in foods. Here, we report the draft genome sequence of S. maltophilia strain CRB139-1, isolated from poultry meat in Japan. The genome size was 4,619,918 bp at 90× coverage. Copyright © 2020 Yamamoto et al.Moraxella catarrhalis is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; however, its response to iron starvation during infection is not completely understood. Here, we announce a sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) data set describing the differential expression of the M. catarrhalis CCRI-195ME proteome under iron-restricted versus iron-replete conditions. Copyright © 2020 Blakeway et al.Here, we report the complete sequence of four influenza A(H1N1) virus samples isolated from cases that occurred during the 2017 epidemic season in Kerala in South India. Sequence analysis showed mutations that differentiate this strain from the reference strain A/California/07/2009 virus. Copyright © 2020 Prasad et al.Vibrio sp. strain OCN044 is a Gram-negative gammaproteobacterium found in marine environments. Presented here is the whole-draft genome sequence of nonpathogenic Vibrio sp. strain OCN044, isolated from a healthy Acropora cytherea colony off the western reef terrace of Palmyra Atoll. Copyright © 2020 Loughran et al.We report here the complete and annotated genome sequence of Pectobacterium brasiliense 1692, a Gram-negative enterobacterium that can cause soft rot disease in many plant hosts.Efforts to catalog viral diversity in the gut microbiome have largely focused on DNA viruses, while RNA viruses remain understudied. To address this, we screened assemblies of previously published mouse gut metatranscriptomes for the presence of RNA viruses. We identified the coding-complete genomes of an astrovirus and five mitovirus-like viruses. Copyright © 2020 Stough et al.Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have suggested a relation between hearing-loss-induced tonotopic reorganization and tinnitus. This large functional magnetic resonance imaging (fMRI) study on humans intended to clarify the relations between hearing loss, tinnitus and tonotopic reorganization. To determine the differential effect of hearing loss and tinnitus, both male and female participants with bilateral high frequency hearing loss, with and without tinnitus, and a control group were included. In a total of 90 participants, bilateral cortical responses to sound stimulation were measured with loudness matched pure-tone stimuli (0.25 – 8 kHz). In the bilateral auditory cortices, the high frequency sound-evoked activation level was higher in both hearing-impaired participant groups, compared to the control group. find more This was most prominent in the hearing loss group without tinnitus. Similarly, the tonotopic maps for the hearing loss without tinnitus group werensory deprivation, it can lead to tinnitus as an unwanted side effect. In this large fMRI study, we provide evidence that tinnitus is related to a more conservative form of reorganization than in hearing loss without tinnitus. This result contrasts with the previous notion that tinnitus is related to excessive reorganization. As a consequence, treatments for tinnitus may need to enhance the cortical plasticity, rather than reversing it. Copyright © 2020 Koops et al.PURPOSE Nintedanib enhances the activity of chemotherapy in metastatic NSCLC. In this phase I/II study, we assessed safety and efficacy of nintedanib plus neoadjuvant chemotherapy, using major pathologic response (MPR) as primary endpoint. EXPERIMENTAL DESIGN Eligible patients had stage IB (≥4 cm)-IIIA resectable NSCLC. A safety run-in phase was followed by an expansion phase with nintedanib 200 mg PO bid (28 days), followed by 3 cycles of cisplatin (75 mg/m2), docetaxel (75 mg/m2) q21 days plus nintedanib, followed by surgery. With 33 planned patients, the study had 90% power to detect an MPR increase from 15% to 35%. RESULTS 21 patients (stages I/II/III, N=1/8/12) were treated. One of 15 patients treated with nintedanib 200 mg achieved MPR (7%, 95% CI 0.2%-32%). Best ORR in 20 evaluable patients was 30% (6/20, 95% CI 12%-54%). 12-month RFS and OS were 66% (95% CI 47%-93%) and 91% (95% CI, 79%-100%), respectively. Most frequent treatment-related G3-4 toxicities were transaminitis and electrolyte abnormalities. Based on an interim analysis the study was discontinued for futility. Higher levels of CD3+ and cytotoxic CD3+CD8+ T cells were found in treated tumors of patients who were alive than in those who died (652.8 vs. 213.4 cells/mm2, P=0.048; 142.3 vs. 35.6 cells/mm2, P=0.018). CONCLUSIONS Although tolerated, neoadjuvant nintedanib plus chemotherapy did not increase MPR rate compared to chemotherapy historical controls. Additional studies of the combination in this setting are not recommended. Post-treatment levels of tumor infiltrating T cells were associated with patient survival. Use of MPR facilitates the rapid evaluation of neoadjuvant therapies. Copyright ©2020, American Association for Cancer Research.