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To action the insights and create “value”, we crafted skillfully designed end-user applications for domain experts to plan, track, predict, compare and monitor domain activities, optimize costs and maximize quality. Today the Nerve Live program enables insights-driven decision making at scale, unlocking productivity and providing transparency across the Novartis Global Drug Development organization and beyond. We identified three main drivers making the Nerve Live program successful and enabling the associated digital transformation to flourish. We discuss the challenges, highlight the benefits, and the importance of leading the way to become future proof. read more This article is protected by copyright. All rights reserved.The novel coronavirus termed SARS-CoV-2 is a major public health challenge. Many maternity units around the country are currently considering management protocols for these patients. We report a case from a tertiary Australian hospital describing an uncomplicated vaginal birth in a SARS-CoV-2 positive mother. To our knowledge this is also the first case described of a mother with COVID-19 not separated from her infant. Management provided supports the current Royal College of Obstetricians and Gynaecologists and World Health Organization guidelines suggesting that it is possible to consider rooming in post delivery for COVID-19 positive parents. Encouragement of breast feeding appears possible and safe when viral precautions are observed. This article is protected by copyright. All rights reserved.Hidradenitis suppurativa (HS) is a debilitating inflammatory disease that is understudied, underfunded, and notable for mean diagnostic delay of approximately 7 years. We aimed to characterize annual HS-related publications across medical fields of study caring for HS in order to measure the extent of awareness, education and ongoing research in this area. This article is protected by copyright. All rights reserved.INTRODUCTION The ideal fixation methods in laparoscopic ventral hernia repair continue to be debated. Early series touted the importance of suture and tack fixation; however, due to the perceived concern for increased pain, newer tack-only fixation methods have emerged. The purpose of this study was to compare fixation methods in laparoscopic ventral hernia repairs using a large hernia database. MATERIALS AND METHODS We retrospectively reviewed data from the Americas Hernia Society Quality Collaborative (AHSQC) database comparing two groups of fixation (all tacks vs. all sutures and tacks and sutures and permanent tacks vs. sutures and absorbable tacks). The primary outcome measures were hernia recurrence, hospital length of stay, surgical site infection, surgical site occurrence, pain intensity scores, and quality-of-life scores evaluated at 30 days, six months, one year, and two years, Propensity score matching was used to strengthen the retrospective nature of the study. RESULTS Eight hundred and fifty-twods when used in laparoscopic ventral hernia repair.INTRODUCTION Although primary total hip arthroplasty (THA) stem designs have evolved from conventional lengths to shorter lengths, revision stems have not undergone a similar change. Tapered, conical prostheses have performed well in primary THA, however their use in revision THA has not been thoroughly investigated. Our purpose was to report the short-term radiographic and clinical outcomes of the Wagner Cone Prosthesis® (Zimmer Biomet, Warsaw, Indiana) in revision THA. MATERIALS AND METHODS An institutional review board approved retrospective study was performed to identify all revision THAs with minimum one-year clinical and radiographic follow up between January 1, 2007 and December 31, 2018, which used a short conical tapered stem to reconstruct the femur. Demographic, surgical, and radiographic variables were collected for each patient. RESULTS Fifteen hips that fit inclusion criteria were identified. Implant survivorship was 93.3% with a mean follow up of 33.6 months. Radiographic analysis revealed mean subsidence of 2.57mm ± 4.31mm and a limb-length difference of 0.69mm ± 12.4mm longer than the contralateral side. Furthermore, pedestal sign was observed on preoperative radiographs of six patients, none of whom suffered periprosthetic fracture or femoral cortex perforation upon insertion of the conical prosthesis. CONCLUSION Our findings suggest that the Wagner Cone Prosthesis® is as a useful implant for revision THA. In our sample, it had excellent survivorship, impressive postoperative radiographic measurements obtained from most recent follow up, minimal mean subsidence, and minimal complication rates. Further prospective studies with longer follow up are needed to determine the efficacy of this stem in revision THA.INTRODUCTION Chronic low back pain can be due to many different causes, including degenerative spondylolisthesis (DS). For patients who do not respond to conservative management, surgery remains the most effective treatment. Open laminectomy alone and laminectomy and fusion (LF) for DS have been widely investigated, however, no meta-analyses have compared minimally invasive decompression with posterior elements preservation (MID) techniques and LF. Minimally invasive techniques might provide specific advantages that were not recognized in previous studies that pooled different decompression strategies together. MATERIALS AND METHODS This was a systematic review and meta-analysis, according to the PRISMA statement, of comparative studies reporting surgical, clinical and radiological outcomes of MID and LF for DS. RESULTS A total of 3202 papers were screened and 7 were finally included in the meta-analysis. MID is associated with a shorter surgical duration and hospitalization stay, and a lower intraoperative blood loss and residual low back pain; however, the residual disability grade was lower in the LF group. Complication rates were similar between the two groups. The rate of adjacent segment degeneration was lower in the MID group, whereas data on radiological outcomes were heterogeneous and not suitable for data-pooling. CONCLUSIONS This meta-analysis suggests that MID might be considered as an effective alternative to LF for DS. Further clinical trials will be needed to confirm our results, better investigate radiological outcomes, and identify patient subgroups that may benefit the most from specific techniques.