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Rollins posted an update 1 year ago
Molecular self-assembly is a widespread natural phenomenon and has inspired several researchers to synthesize a compendium of nano/microstructures with widespread applications. Biomolecules like proteins, peptides and lipids are used as building blocks to fabricate various nanomaterials. Supramolecular peptide self-assembly continue to play a significant role in forming diverse nanostructures with numerous biomedical applications; however, dipeptides offer distinctive supremacy in their ability to self-assemble and produce a variety of nanostructures. Though several reviews have articulated the progress in the field of longer peptides or polymers and their self-assembling behavior, there is a paucity of reviews or literature covering the emerging field of dipeptide-based nanostructures. In this review, our goal is to present the recent advancements in dipeptide-based nanostructures with their potential applications.Curcumin has become a popular product used to decrease inflammation and enhance recovery from exercise.
To determine the effects of curcumin supplementation on delayed onset muscle soreness and muscle power following plyometric exercise.
Participants (
= 22; five females, 17 males) consumed either curcumin (500 mg) or placebo twice daily for 10 days (6 days pre, day of and 3 days post exercise). Participants completed 5 x 20 drop jumps on day 7. Blood sampling and recovery tests were assessed at pre-supplementation, 24-hours and immediately pre-exercise, and immediately post-, 24, 48 and 72-hours post-exercise. Blood markers included serum creatine kinase (CK) and erythrocyte sedimentation rate (ESR), while soreness was measured during a squat and post vertical jump.
Both groups experienced muscle damage post-exercise with elevated CK (403 ± 390 ul;
< 0.01), soreness with squatting (38 ± 29 mm;
< 0.01), and vertical jump (36 ± 30 mm;
< 0.01). Soreness was greater in placebo vs. curcumin 48 h and 72 h post-exercise (
< 0.01); however, CK was not significantly different between groups (
= 0.28) despite being >200 IU·
greater 24 hr post exercise in placebo vs. curcumin. ESR was significantly greater immediately post-exercise (6.3 ± 5.6 vs. 2-Methoxyestradiol supplier 3.4 ± 2.6 mm/hr;
= 0.03), however these were within the normal range for this test and not significantly different between groups (
= 0.25). Vertical jump decreased over time in the placebo, but not curcumin group (19.8 ± 4.8 vs. 21.4 ± 3.2 in;
= 0.01).
These data suggest curcumin reduces soreness and maintains muscular power following plyometric exercise.
These data suggest curcumin reduces soreness and maintains muscular power following plyometric exercise.With the increasing demand for natural products by the consumer in the marketplace it is necessary to see a proportional increase in behind-the-scenes science to ensure that the ideology of safety and honesty, that is justifiably expected by the wider public, is adequately satisfied. It is of essence to have a fair yet firm governance of nutraceuticals, cosmetics, therapies, and foods. However, with increasing sophistications in adulteration and “claim” loopholes that make it easier for adulterated or counterfeited natural products to be “fudged” to meet the pharmacopeia standards, governance protocols must utilize an “identification and authentication” approach that goes beyond the Pharmacopeia standards to help regulate and transparently communicate natural products in the commercial context. While it is becoming a rat race in keeping commercial natural products honest, modern technology can support authenticators and adequately defeat these challenges.This study aimed to review the literature on studies that evaluated the effects of omega-3 supplementation on parameters of diabetes in humans. An online search was conducted in the following databases Pubmed, LILACS, Scielo, Scopus, and Web of Science. It included experimental studies that investigated the effects of omega-3 supplementation for diabetes treatment or prevention and its relationship with fasting blood glucose, insulin resistance, and glycated hemoglobin. Observational, non-human studies and non-randomized clinical trials were excluded. The Cochrane scale assessed the quality of the studies. A meta-analysis was carried out to evaluate the effect of omega-3 on fasting blood glucose, insulin resistance, and glycated hemoglobin. Thirty studies were included in the review. Almost 70% (n = 20) demonstrated at least one significant effect of the omega-3 supplementation related to diabetes. In the meta-analysis, there was a significant effect on the reduction of fasting blood glucose [SMD -0.48; CI95% -0.76, -0.19; p = 0.01; I2 = 88%] and insulin resistance [SMD -0.61; CI95% -0.98, -0.24; p = 0.01; I2 = 90%]. For glycated hemoglobin, there was no significant effect in the meta-analysis. This systematic review with meta-analysis demonstrated that supplementation with omega-3 has protective effects on diabetes parameters.There is an emergent demand for sustainable and alternative protein sources such as insects and microorganisms that meet the nutritional requirements. Microalgae possess valuable substances that could satisfy the population’s dietary requirement, medicinal purpose, and energy, aligned with effective processing techniques. Several disruption techniques were applied to microalgae species for protein recovery and other compounds. The thick microalgae cell wall makes it difficult to recover all the valuable biomolecules through several downstream processes. Thus, forethought key factors need to be considered when choosing a cell lysis method. The most challenging and crucial issue is selecting a technique that requires consideration of their ability to disrupt all cell types, easy to use, purity degree, reproducible, scalable, and energy efficient. This review aims to provide useful information specifically on mechanical and non-mechanical disruption methods, the status and potential in protein extraction capacities, and constraints.