Jimenez

Furthermore, CS is an effective alternative model of intraperitoneal polymicrobial sepsis in adult mice and can now be considered the “gold standard” for experiments in neonatal mice.Implantation of bacteria embedded in a fibrin clot allows for successful establishment of sepsis in preclinical models. This model allows the investigator to modulate…[Read more]

Here we summarize the status of COVID-19 serology testing, discuss challenges, and provide future directions for improvement.

To examine the impact of a new approach, Get SET Early, on the rates of early autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate-treat chain.

After attending Get SET Early…[Read more]

Recent technological advances in brain recording and machine learning algorithms are enabling the study of neural activity underlying spontaneous human behaviors, beyond the confines of cued, repeated trials. However, analyzing such unstructured data lacking a priori experimental design remains a significant challenge, especially when the data is…[Read more]

the vertical transmission of maternal antibodies until they are able to build up their own adaptive immunity.

A decline in the number of patients presenting with myocardial infarction was reported from the beginning of the COVID-19 pandemic onward. It is thought that measures introduced to stem the pandemic, such as the lockdown, contributed…[Read more]

pression analysis and VIGS assay provided direct evidences on GhWAKs participation in the cotton resistance to V. dahliae.

A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes,…[Read more]

, which effectively improved mechanical properties.Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. To date, the etiology of the disease is still unclear, with evidence of reactive oxygen species, mitochondrial dysfunction, iron homeostasis perturbation, protein misfolding and protein…[Read more]

Our results from VSIG1 KO mice suggest that VSIG1 may not play essential roles in spermatogenesis and normal testis development, function, and maintenance. VSIG1 in sperm is dispensable for spermatogenesis and male fertility in mice. As several genes are known to possess slightly different functions depending on the species, the importance and…[Read more]

or virulence determinants.

Over the last years, there has been an increasing concern about a global decline in men’s fertility. Specifically, some evidence indicates that sperm quality has decreased over the last years. However, reports showing the changes in sperm quality with time are inconsistent. Part of the contradictions between studies…[Read more]

Furthermore, a Python code for generating textile-like ECG signals with variable SNR was also made available online. Finally, to provide a benchmark for the performance of R-peak detection algorithms on textile ECG, the five common R-peak detection algorithms Pan & Tompkins, improved Pan & Tompkins (in Biosppy), Hamilton, Engelse, and Khamis, were…[Read more]

The OTML panel demonstrated robustness and reproducibility for TMB evaluation. Results also suggest the possibility of using the panel for mutational signatures and variant detection. Collaborative efforts between academia and companies are crucial to accelerate the translation of new biomarkers into clinical research.A series of…[Read more]

Conclusions For SGM-POC, experiences of heterosexism within their racial/ethnic communities may lead to internalization of those negative attitudes. A consequence of internalizing heterosexist attitudes from one’s racial/ethnic group could be a feeling that one’s sexual orientation and racial/ethnic identities must remain separate, perhaps to…[Read more]