Peters

The as-synthesized DOX/PEI@TeNP system can produce reactive oxygen species (ROS) under near-infrared (NIR) light irradiation and features a high photothermal conversion efficiency due to its strong NIR absorbance. Therefore, this study provides an effective strategy for the effective design of nano-drugs, which can be used for the accurate…[Read more]

001 and p = 0.004). Contraction strength explained, at most, 4% of UGH (r = 0.17) or LH (r = 0.20) shortening during contraction (r = 0.17 and r = 0.20, respectively), indicating that these factors are largely independent. After controlling for prolapse size, resting UGH and levator defect status were associated with straining UGH (p < 0.001,…[Read more]

Knockdown of Piezo2 in NG also attenuated the baroreflex and increased serum norepinephrine (NE) concentration in WKY rats. Co-immunoprecipitation experiment suggested that Piezo2 interacted with Neural precursor cell-expressed developmentally downregulated gene 4 type 2 (Nedd4-2, also known as Nedd4L); Electrophysiological results showed that…[Read more]

ute to the diagnosis, treatment and follow-up of diabetic nephropathy in the future.

The Environmental Determinants of Diabetes in the Young (TEDDY) is a prospective birth cohort designed to study type 1 diabetes (T1D) by following children with high genetic risk. An integrative multi-omics approach was used to evaluate islet autoimmunity…[Read more]

The evidence that oxidation and inactivation of OGs and CDs may be a general strategy of plants for controlling the homeostasis of DAMPs is discussed. The possibility exists of discovering additional oxidative and/or inactivating enzymes targeting other DAMP molecules both in the plant and in animal kingdoms.Raffinose family oligosaccharides…[Read more]

Patients suffering from malignant diseases receive very often highly emetogenic chemotherapy as part of their treatment. With the aim of assessing the efficacy of cannabinoids in treating chemotherapy-induced nausea and vomiting (CINV), we searched the literature published until April 2020 in Medline/PubMed, Embase, the Cochrane Controlled Trials…[Read more]

38, 95% CI 0.15-0.98, p=0.047) and OS (HR 0.37, 95% CI 0.13-0.99, p=0.047). In subgroup analysis, the CR after CCRT followed by ACT group showed significantly higher locoregional recurrence-free survival (p=0.02), OS (p=0.003), distant-metastasis free survival (p=0.07), and PFS (p=0.01) than the other three groups.

Tumor regression 1month…[Read more]

3 (IQR 1.8-13.1) years. Using GSRS, 88% of participants reported at least 1 gastrointestinal symptom, most commonly indigestion (57%) and diarrhea (54%). Using GIQLI, 42% and 38% of participants reported mild and moderate QOL impairment, respectively. Gastrointestinal symptoms were predicted by female sex (coefficient-0.11, 95% CI-0.21 to-0.02)…[Read more]

0%) had significantly higher DAS28-CRP (3.6 vs 3.0), HAQ-DI (0.50 vs 0.12), and mTSS (21 vs 7) than young RA patients without myopenia (n = 280, 43.5%; all p less then 0.0083). Multivariate logistic and linear regression analyses showed that myopenia, high HAQ-DI, active smoking, hypertension, diabetes, and coronary atherosclerotic heart disease…[Read more]

The association between a history of hypertensive disorders of pregnancy (HDP) and subsequent type 2 diabetes (referred to throughout as diabetes) remains inconclusive. We reviewed the most recent evidence to quantify the association of previous HDP with incident diabetes.

A systematic search of MEDLINE, Embase and CINAHL was performed up…[Read more]

The transboundary Tigris-Euphrates Basin (TEB) is prone to water-scarcity disputes. Water scarcity is related to aridity, climate extremes, limited supplies, upstream reservoir storage, rising water demand, and population growth. Understanding the water budget and storage changes in the basin in relation to hydrological extremes is fundamental to…[Read more]