Holmes

We found that polygenic scores were associated beyond APOE with clinical diagnosis, CSF-tau levels and, to a minor degree, with progressive atrophy. However, for many other tested traits such as clinical disease progression, CSF amyloid, cognitive decline and cortical amyloid load, the additional effects of polygenic burden beyond APOE were of…[Read more]

Concisely, the GSLM with coefficients of determination (R2) 99.957% and root mean squared error (RMSE) of 2.121% outperformed the SVM-FFA with R2 99.59%, RMSE 3.27%, ANN with R2 99.56%, RMSE 3.3%, ANFIS with R2 98.9%, RMSE 4.3%, GP with R2 99.89%, RMSE 3.47%, GEP with R2 94.75%, RMSE 4.15% for forecasting weekly time series. In forecasting monthly…[Read more]

injury burden. LEVEL OF EVIDENCE Prognostic, level III.BACKGROUND Patients with blunt cerebrovascular injuries (BCVI) are at risk of thromboembolic stroke. Although primary prevention with antithrombotic therapy is widely used in this setting, its effectiveness is not well defined, and requires further investigation. The aim of this study was to…[Read more]