Activity

The purpose of this case report is to demonstrate lung perfusion changes on dual-energy CT (DECT) in patients with Coronavirus disease 2019 (COVID-19). Since the first case of COVID-19 was reported in Wuhan, Hubei province in China, the spectrum of lung parenchymal findings has been well described but the underlying pathophysiology is less well understood. DECT imaging contributes to the growing evidence that vascular dysregulation has an important role in the underlying pathophysiology of the disease. Three patients with reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 underwent DECT scans. One patient had a DECT for persistent spikes in temperature while the other two patients underwent dual-energy CT pulmonary angiograms (CTPA) for worsening shortness of breath, elevated D dimers and suspected pulmonary embolism. The perfusion abnormalities include focal areas of both hyperperfusion, hypoperfusion, and areas of hypoperfusion surrounded by hyperemia. In addition, dilatation of segmental and subsegmental pulmonary arteries was seen in relation to the lung parenchymal change. DECT has proven useful in supporting the hypothesis that vascular dysregulation plays a significant role in the pulmonary pathophysiology of COVID-19. Early identification and a high index of suspicion is required in the emergency department setting to identify and isolate cases even prior to the results of RT-PCR test being available. Vascular changes on DECT may be an additional radiological feature in detecting the presence of and predicting the severity of disease in the emergency department or acute care setting.

To determine the incidence, injury type, injury associations, and management of patients with renal vein injuries following trauma.

This is a 10-year single-center retrospective observational study of patients with renal vein injuries identified on admission abdominopelvic CT following trauma. Our institutional trauma registry and radiology information system (RIS) was used to identify patients with renal vein injuries. The medical records and imaging exams were reviewed to determine venous injury type, associated injuries, management, and outcomes.

Fifteen (15) patients with renal vein injuries (N = 9 right side) were identified out of 36,077 trauma evaluations, for an overall incidence of 0.042%. Eight (53.3%) were male with a mean age of 36.3years (range 9-67years) and a mean Injury Severity Score (ISS) of 32 (range 13-57). The most common imaging findings were pseudoaneurysm formation with or without intimal injury and intraluminal thrombus seen in 86.7% of the cohort. Twelve patients (80.0%) had otbination with an intimal injury and intraluminal thrombus. Conservative, nonoperative management was successfully employed in all cases with no renal vein specific mortalities.To investigate the effect of supplementation of L-arginine (AR) on sub-fertile buffalo-bulls’ ejaculates, 25 ejaculates of poor motility (40 to 55%) were collected by artificial vagina from 5 buffalo-bulls and extended with Tris-yolk extender (110) supplemented with different concentrations of AR (0, 3, 4, 5, and 6 mM). Semen was cooled gradually to 4 °C within 2 h and incubated at 4 °C for additional 2 h. Incubated semen samples were evaluated by computer-assisted semen analysis. Results showed that addition of 5 mM AR increased (P  0.05) effect on the activity of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase in semen extender. Supplementation of Tris-yolk extender with L-arginine (5 or 6 mM) can improve sperm motility, velocity, vitality, and functional sperm and can decrease tail and neck abnormalities of sub-fertile buffalo ejaculate after 4 h incubation at cool temperature.Herein, a simple, efficient ratiometric chemosensor was reported for the selective sensing of Pb2+ and F- ions using thiophene functionalized hydrazone as a chemical probe. Hydrazone moiety was developed by utilizing thiophene/naphthalene as a platform for the particular recognition of cation and anion. The structures of the precursor (Z)-(1-(5-bromothiophen-2-yl)ethylidene)hydrazine (ABTH) and the final probe 1-((Z)-(((Z)-1-(5-bromothiophen-2-yl)ethylidene)hydrazono)methyl)naphthalen-2-ol (NAPABTH) were confirmed by 1H, 13C-NMR and LC-MS spectroscopic methods. The interaction of NAPABTH with Pb2+ and F- ions was visually observed by the formation of pink and dark yellow solutions, respectively. The detection limits were found to be very low for Pb2+ as 1.06 ppm and for F- ions as 3.72 nM. This visual detection of Pb2+/F- ions with satisfactory outcomes obtained from UV-Vis titrations. The sensing mechanistic pathways and stoichiometric ratios were obtained from DFT and Job’s plot, respectively. Onalespib molecular weight The observed results are highly promising as highly selective chemosensor with lower detection limits for Pb2+ and F- ions. This strategy could exhibit tremendous applications for the selective sensing of heavy metal cations with rapid sensitivity for the design of new devices.In this investigation, a simple, green and facile fluorescence mrtod using carbon dots (CDs) of hazelnut kohl is described for selective detection of dopamine (DA). The sensing system is based on hazelnut kohl (the black soot of kohl) which is used as a carbon source. Generally, kohl is a traditional eye cosmetic that used in different parts of the world and synthesized by the combustion process like burning natural materials. Here, it has been proven that black soot (kohl) obtained from hazelnut has a carbon dot structure and can be used for sensory applications. Some characterization methods are carried out to reveal the kohl structure. Also, the photoluminescence properties of the prepared CDs of kohl are investigated. It is found that the size of CDs is 2-4 nm. Besides, under the optimal conditions, the fluorescence of CDs is used for DA determination. CDs fluorescence intensity is decreased linearly with the increase of DA concentration. By using the fluorescence dependency toward the DA concentration, DA can be determined in the range 0.5-30 μM with the limit of detection of 0.30 μM. Finally, this method is successfully applied to discriminate the DA in the real samples (healthy human serum and cerebrospinal fluid (CSF)) which shows acceptable efficiently for diagnostic purposes. The fluorescence of carbon dots, prepared from Hazelnut Kohl, is quenched in the presence of dopamine.