Crosby

The intercellular communication via gap junctions leads, in certain circumstances, to a bioelectric state propagation to neighbor cells, in a chain-like reaction, till an electric discontinuity is reached. However, this is a reversible process, and it was shown experimentally that, by implementing a therapy targeted on cell ion exchange channels,…[Read more]

1%) had SDD. For admitted patients, mean length of stay was 1.5 (1.3) days. Among cases traditionally involving overnight stay, rates of SDD were significantly higher in 2020 than 2010 (84% vs. 32%, p < 0.001), and increased over time. Overall rates of 30-day readmission and ED visits were low (1.9% and 2.6%, respectively) and did not differ bas…[Read more]

Mid-course evaluation identified facilitators and barriers to implementation of the WIC. At the conclusion of the pilot period, we evaluated the commitments implemented by each signatory to the WIC. Six of 8 employers fulfilled at least 5 commitments as articulated in the WIC, and 4 employers fulfilled 10 or more commitments.

The WIC is a…[Read more]

Polycystic ovary syndrome (PCOS) is a common endocrine disease in females that is characterized by hyperandrogenemia, chronic anovulation, and polycystic ovaries. However, the exact etiology and pathogenesis of PCOS are still unknown. The aim of this study was to clarify the bacterial, stress status, and metabolic differences in the gut…[Read more]

We aim to characterize the drug resistance mutations in reverse transcriptase gene of HIV-1 subtype C-infected North Indian population in those who are failing first-line antiretroviral therapy (ART) and if these mutations are associated with mortality. We also attempted the assessment of switch over to second-line antiretroviral therapy in these…[Read more]

Individuals with Fetal Alcohol Spectrum Disorder (FASD) and prenatal alcohol exposure (PAE) face elevated rates of postnatal environmental adversity across the lifespan.

We explored early adversity among children and adolescents with PAE.

Our sample included 333 children and adolescents with PAE assessed at a Canadian FASD…[Read more]

A one-pot, three-component protocol for the synthesis of 1,2,3-trisubstituted indoles has been developed, based upon a Fischer indolisation-indole N-alkylation sequence. This procedure is very rapid (total reaction time under 30 minutes), operationally straightforward, generally high yielding and draws upon readily available building blocks (aryl…[Read more]

New radiological findings such as the central vein sign and iron rims, should be considered within the typical MRI features of this disease with the objective of minimizing MRI-based diagnostic errors.

Although the optic nerve has not been included as one of the topographies required to demonstrate demyelinating lesion disseminated in space in…[Read more]

381, P=0.036). Similar findings were obtained in subgroup analysis of patients with AF and only mild MR. Conclusions The present study demonstrated that AF is associated with poor prognosis in patients with ADHF with mild to moderate MR, but not in those without MR.Background Atrial fibrillation (AF) is a common arrhythmia. Although radiation…[Read more]