Activity

To explore abortion method preference, interpersonal and cultural factors associated with preference, and whether, among people with a preference for medication abortion, those presenting past 10 weeks gestation had experienced more obstacles to care.

In 2019, we invited people aged 15 to 45 years presenting to 4 U.S. abortion clinics to complete a self-administered, anonymous iPad survey prior to seeing the health care provider. Questions focused on their pregnancy, including self-reported gestational age and experiences accessing abortion care, including abortion method preference. We used multivariate logistic regressionto assess associations between worry about perceived pregnancy-related stigma or abortion-related health myths and abortion method preference.

The majority (784 [77%]) of those approached (1092) initiated the survey and 712 responded to the preference question. Most (597 [84%]) preferred a method 246 (41%) preferred medication abortion and 351 (59%) an in-clinic procedure. About one-tity to obtain their preferred method. Removing barriers to clinic access may enhance people’s ability to obtain their preferred abortion method.

Pregnancy-related stigma and misinformation, such as health and safety myths promulgated by state-mandated abortion counseling, may motivate preference for medication abortion. Abortion access obstacles may impede individuals’ ability to obtain their preferred method. Removing barriers to clinic access may enhance people’s ability to obtain their preferred abortion method.Marine algae have long been explored as food, feed, additives, drugs, and pesticides, yet now the framework is moving towards the algae mediated green synthesis of nanoparticles (NPs). This work is expanding step by step, like algae, are a rich origin of natural compounds. Recently, algae capped and stabilized NPs have picked up far and wide consideration as a less toxic, easy handling, cost effective, eco-friendly, usage in several science fields in nano size, safer to use, and greener method. The natural substance from algae acts as capping or reducing and stabilizing agent in the metal salts to metal, metal oxide, or bimetallic NPs conversion. The NPs using algae could either be intracellular or extracellular relying upon the area of NPs. Among the different scope of algae, reviews are explored in the previous report, still, different NPs using algae and their characterization, mechanism of activity is yet to be summarized. Because of the biocompatibility, good and remarkable physicochemical properties of NPs, the algal biosynthesized NPs have additionally been read for their biomedical applications, which include antibacterial, antioxidant, free radical scavenging, antifungal, anticancer, and biocompatibility properties. In this survey, the reasoning behind the algae mediated biosynthesis of various NPs from different algae origin have been explored. Besides, a piece of knowledge into the component of biosynthesis of NPs from marine algae and their biomedical applications has been summarized.The objective of this short paper is to call upon the scientific community to channel its attention to the duty and heedfulness of social justice issues. While recognized for decades the impact of social injustice on public health and its disproportionate effects on poorer communities, little has been done to systematically address it. Here, we provide several examples pertinent to the health outcomes associated with social injustice and call upon the scientific community to attend to the issue and antagonize those who attempt to subvert science and its role in ensuring social justice in health.By mid-September 2020, over 1.33 million confirmed COVID-19 cases and 32 thousand deaths had been reported in Africa. Global research on COVID-19 went ‘viral’ with a record 3487 research contributions comprising of 2062 journal papers and 1425 preprints published within the first three months following the outbreak of COVID-19. Surprisingly, the silence of the African research community has been unprecedented – contributing a paltry 0.6% (22 contributions), a figure nearly matched by Colombia (18 publications). Until now, a comprehensive perspective on the reasons for this subdued research response, and COVID-19 themes critical to Africa has been missing. Merestinib We posit that while a milieu of factors accounts for this silence, unprecedented research opportunities exist to support COVID-19 decision and policy formulation in Africa. The subdued response reflects weak research systems, characterized by deep-rooted challenges, including severe lack of research expertise, funding, and infrastructure, coupled with poor ws a need to (1) strengthen local research capacity and evaluation systems, (2) consider biosafety and ethical issues, (3) initiate cross-disciplinary research and global collaboration on COVID-19, and (4) integrate science communication in COVID-19 programs.Cutaneous melanoma is the deadliest form of skin cancer, and gambogic acid (GA) exhibits potent anti-melanoma activity. However, clinical application of GA via intravenous injection and oral administration is limited by systemic toxicity and rapid metabolism in the blood. Here, we developed a new, topical route of GA delivery for anti-melanoma activity and reduction of systemic toxicity. The results indicated that the barrier of the stratum corneum (SC) and low diffusion of GA in the hydrophilic viable skin (epidermis and dermis) limited the GA penetration through intact skin. The combination of azone (AZ) and propylene glycol (PG) showed obvious synergistic effects on skin penetration by GA via improving the permeability of the SC and greatly increasing the skin accumulation of GA, thereby forming a high drug concentration in the skin and achieving a topical targeted treatment of melanoma. In addition, GA (AZ-PG) achieved the same anti-melanoma effect via topical delivery as via intravenous injection. Intravenous injection and oral administration of GA induced remarkable pathological changes in various organs in mice, whereas GA was not toxic to various organs or to the skin via topical delivery. These findings indicated that topical administration of GA is an alternative route for melanoma treatment.