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The TMP recovery rate of PEG-MWCNT membrane after cross flushing was 79.4%, while that of raw MWCNT-COOH and MWCNT membrane were only 14.9% and 28.3%, respectively. PEG non-covalent functionalization improved the antifouling ability of the raw MWCNT membranes and reduced the irreversible fouling, which effectively prolonged the service life of MWCNT membrane.When faced with the task of trying to “read” a stranger’s thoughts, what cues can perceivers use? We explore two predictors of empathic accuracy (the ability to accurately infer another person’s thoughts) use of stereotypes about the target’s group, and use of the target’s own words. A sample of 326 White American undergraduate students were asked to infer the dynamic thoughts of Middle Eastern male targets, using Ickes’ (Ickes et al. 1990) empathic accuracy paradigm. We predicted use of stereotypes would reduce empathic accuracy because the stereotypes would be negative and inaccurate. However, more stereotypical inferences about the target’s thoughts actually predicted greater empathic accuracy, a pattern in line with past work on the role of stereotypes in empathic accuracy (Lewis et al. 2012), perhaps because the stereotypes of Middle Easterners (collected from a sample of 60 participants drawn from the same population) were less negative than expected. In addition, perceivers who inferred that the targets were thinking thoughts that more closely matched what the target was saying out loud were more empathically accurate. Despite the fact that words can be used intentionally to obscure what a target is thinking, they appear to be a useful cue to empathic accuracy, even in tricky contexts that cross cultural lines.We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing. Fluorofurimazine chemical structure To date, wild-type nuclear genome mutation rates are known for over 40 eukaryotic species, while measurements in mismatch repair-defective organisms are fewer in number and are concentrated on Saccharomyces cerevisiae and human tumors. Well-studied organisms include Drosophila melanogaster and Mus musculus, while less genetically tractable species include great apes and long-lived trees. A variety of techniques have been developed to gather mutation rates, either per generation or per cell division. Generational rates are described through whole-organism mutation accumulation experiments and through offspring-parent sequencing, or they have been identified by descent. Rates per somatic cell division have been estimated from cell line mutation accumulation experiments, from systemic variant allele frequencies, and from widely spaced samples with known cell divisions per unit of tissue growth. The latter methods are also used to estimate generational mutation rates for large organisms that lack dedicated germlines, such as trees and hyphal fungi. Mechanistic studies involving genetic manipulation of MMR genes prior to mutation rate determination are thus far confined to yeast, Arabidopsis thaliana, Caenorhabditis elegans, and one chicken cell line. A great deal of work in wild-type organisms has begun to establish a sound baseline, but far more work is needed to uncover the variety of MMR across eukaryotes. Nonetheless, the few MMR studies reported to date indicate that MMR contributes 100-fold or more to genome stability, and they have uncovered insights that would have been impossible to obtain using reporter gene assays.

The prevalence of malnutrition in patients with cirrhosis is considerably high. Body mass index (BMI) is a well-known risk factor for malnutrition, but the other risk factors are unknown. We investigated the prevalence of malnutrition and its risk factors in patients with cirrhosis.

In total, 361 patients with cirrhosis were enrolled. Muscle quality and quantity were retrospectively assessed using the grip strength test and bioelectrical impedance analysis. Subjective global assessment (SGA) of malnutrition and dietary intake assessments were performed by a clinical dietician.

The prevalence rates of sarcopenia, malnutrition assessed by SGA, and inadequate energy intake were 22.7%, 13.6%, and 27.5%, respectively. The prevalence of malnutrition evaluated using any of the assessment methods was 46.3%, and no significant difference was observed according to liver disease etiology. The prevalence of malnutrition increased with the increasing disease severity (

= 0.034) and decreasing BMI (

= 0.007). The prevalence of malnutrition was 64.4% in patients with protein intake <1.0 g/kg. Low protein intake, Child-Pugh C grade, older age, and low BMI were independent risk factors for malnutrition in multivariate analysis.

Low protein intake (<1.0 g/kg) is an independent risk factor for malnutrition in patients with cirrhosis.

Low protein intake ( less then 1.0 g/kg) is an independent risk factor for malnutrition in patients with cirrhosis.To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of interest to devise formulation strategies that allow increased drug loading (DL) without compromising dissolution performance. The aim of this study was to explore how surfactant addition impacts drug release as a function of drug loading from a ternary ASD, using felodipine as a model poorly soluble compound. The addition of 5% TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate, a surfactant) to felodipine-polyvinylpyrrolidone/vinyl acetate ASDs was found to facilitate rapid and congruent (i.e., simultaneous) release of drug and polymer at higher DLs relative to binary ASDs (drug and polymer only). For binary ASDs, good release was observed for DLs up to less then 20% DL; this increased to 35% DL with surfactant. Microstructure evolution in ASD films following exposure to 100% relative humidity was studied using atomic force microscopy coupled with nanoscale infrared imaging. The formation of discrete, spherical drug-rich domains in the presence of surfactant appeared to be linked to systems showing congruent and rapid release of drug and polymer. In contrast, a contiguous drug-rich phase was formed for systems without surfactant at higher DLs. This study supports the addition of surfactant to ASD formulations as a strategy to increase DL without compromising release. Furthermore, insights into the potential role of surfactant in altering ASD release mechanisms are provided.