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97. Furthermore, BT and RF models produced the best prediction results and CART performed better than LR. Lastly, urban, physical inactivity, number of tested per population, population density, and total hospital beds per population were the most influential factors on efficiency.The human plasma comes into contact with virtually all the cells in the human body and can be easily sampled through phlebotomy […].In this paper, we discuss the problem of device-free localization and tracking, considering multiple bodies moving inside an area monitored by a wireless network. The presence and motion of non-instrumented subjects leave a specific footprint on the received Radio-Frequency (RF) signals by affecting the Received Signal Strength (RSS) in a way that strongly depends on people location. The paper targets specifically the modelling of the effects on the electromagnetic (EM) field, and the related inference methods. A multiple-body diffraction model is exploited to predict the impact of these bodies on the RSS field, i.e., the multi-body-induced shadowing, in the form of an extra attenuation w.r.t. the reference scenario where no targets are inside the monitored area. Unlike almost all methods available in the literature, that assume multi-body-induced shadowing to sum linearly with the number of people co-present in the monitored area, the proposed model describes also the EM effects caused by their mutual interactions. As a relevant case study, the proposed EM model is exploited to predict and evaluate the effects due to two co-located bodies inside the monitored area. The proposed real-time localization and tracking method, exploiting both average and deviation of the RSS perturbations due to the two subjects, is compared against others techniques available in the literature. Finally, some results, based on experimental RF data collected in a representative indoor environment, are presented and discussed.The introduction of fluorophores into RNA for both in vitro and in cellulo studies of RNA function and cellular distribution is a subject of great current interest. Here I briefly review methods, some well-established and others newly developed, which have been successfully exploited to site-specifically fluorescently label interior positions of RNAs, as a guide to investigators seeking to apply this approach to their studies. Most of these methods can be applied directly to intact RNAs, including (1) the exploitation of natural posttranslational modifications, (2) the repurposing of enzymatic transferase reactions, and (3) the nucleic acid-assisted labeling of intact RNAs. In addition, several methods are described in which specifically labeled RNAs are prepared de novo.This report is part of a larger study designed to rapidly and efficiently screen potential treatments for Gulf War Illness (GWI) by testing nine different botanicals. In this placebo-controlled, pseudo-randomized, crossover clinical trial of 20 men with GWI, we tested three botanical agents with putative peripheral and central anti-inflammatory actions curcumin (Curcuma longa), boswellia (Boswellia serrata), and French maritime pine bark extract (Pinus pinaster). Participants completed 30 +/- 3 days of baseline symptom reports, followed by 30 +/- 3 days of placebo, 30 +/- 3 days of lower-dose botanical, and 30 +/- 3 days of higher-dose botanical. Participants then repeated the process with a new botanical until completing up to three botanical cycles. Data were analyzed using linear mixed models. Curcumin reduced GWI symptom severity significantly more than placebo at both the lower (p less then 0.0001) and higher (p = 0.0003) dosages. Selleckchem Empagliflozin Boswellia was not more effective than placebo at reducing GWI symptoms at either the lower (p = 0.726) or higher (p = 0.869) dosages. Maritime pine was not more effective than placebo at the lower dosage (p = 0.954) but was more effective than placebo at the higher dosage (p = 0.006). This study provides preliminary evidence that curcumin and maritime pine may help alleviate symptoms of GWI. As a screening study, a final determination of the efficacy of these compounds for all individuals with GWI cannot be made, and further studies will need to be conducted to determine strength and durability of effects, as well as optimal dosage. These results suggest that GWI may, at least in part, involve systemic inflammatory processes. This trial was registered on ClinicalTrials.gov (NCT02909686) on 13 September 2016.We present a compact laser-induced fluorescence (LIF) spectrometer prototype (SFIDA-405) designed for in-field operation in polar environments. It uses 405 nm excitation to acquire LIF spectra in the 450-930 nm spectral range on a solid surface via an optical-fiber coupled measurement head. The prototype (battery powered; module + measurement head weight less then 1.6 kg) is controlled via a military-grade smartphone and has a limit of detection for chlorophyll better than 5 ng/cm2. The instrument was successfully tested during two summer field campaigns in the Arctic (Svalbard Islands) and Antarctic (Southern Victoria Land) regions for studying biological soil crusts. To the best of the authors’ knowledge, this represents the first LIF spectrometer used in situ in Antarctica to acquire LIF spectra directly on biological soil crusts. Finally, the paper also suggests the use of the SFIDA-405 prototype for different application fields.Brucellosis, caused by the facultative intracellular bacteria Brucella species, is one the most prevalent zoonoses worldwide […].Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is an innovative laparoscopic intraperitoneal chemotherapy approach with the advantage of a deeper tissue penetration. Thus far, oxaliplatin has been administered at an arbitrary dose of 92 mg/m2, cisplatin at 7.5 mg/m2 and doxorubicin 1.5 mg/m2. This is a model-based approach phase I dose escalation study with the aim of identifying the maximum tolerable dose of the three different drugs. The starting dose of oxaliplatin was 100 mg/m2; cisplatin was used in association with doxorubicin 15 mg/m2 and 3 mg/m2 were the respective starting doses. Safety was assessed according to Common Terminology Criteria for Adverse Events (CTCAE version 4.03). Thirteen patients were submitted to one PIPAC procedure. Seven patients were treated with cisplatin and doxorubicin and 6 patients with oxaliplatin; no dose limiting toxicities and major side effects were found. Common adverse events included postoperative abdominal pain and nausea. The maximum tolerable dose was not reached.