Activity

These data further document health conditions that affect plutonium biokinetics and organ deposition and retention patterns and suggest that health status should be considered when conducting plutonium bioassays as these may alter subsequent dosimetry and risk models.

Most people are frequently exposed to chemicals and chemical products. This study provides basic information on the outcomes of acute chemical ingestion of patients aged under 19 years.

Patients aged under 19 years who had ingested chemicals and thus visited the emergency department between January 2011 and December 2016 were included in this study.

In all, 1,247 patients included (1,145 in the unintentional group and 102 in the intentional group). The mean age was 3.27±4.77 in the unintentional ingestion group and 16.49±1.94 in the intentional group. In the unintentional group, detergents were most frequently ingested (by 219 patients), followed by hypochlorite-based agents, ethanol, sodium hydroxide, acetone, silica gel, and citric acid. Cases of boric acid (odds ratio [OR] = 6.131), ethylene glycol (OR = 6.541), glacial acetic acid (OR = 7.644), other hydrocarbons (OR = 4.496), hypochlorite-based agent (OR = 2.627), nicotine (OR = 5.635), and sodium peroxocarbonate (OR = 6.783) ingestion was associated with a significantly high admission rate. In the intentional group, there were 54 cases of ingestion of hypochlorite-based agent, followed by detergent, ethylene glycol, ethanol, methanol and sodium peroxycarbonate. The significant risk factors for admission in the intentional group were ingestion of ethylene glycol (OR = 37.333) and hypochlorite-based agent (OR = 5.026). There was no mortality case.

The most commonly ingested substances were sodium hypochlorite (hypochlorite-related agent), surfactants (detergent and soap), and ethanol. The ingestion of hypochlorite or ethylene glycol was the main risk factor for admission. Intentional ingestion was higher in adolescents than in children.

The most commonly ingested substances were sodium hypochlorite (hypochlorite-related agent), surfactants (detergent and soap), and ethanol. The ingestion of hypochlorite or ethylene glycol was the main risk factor for admission. Intentional ingestion was higher in adolescents than in children.Normative modeling is an increasingly popular method for characterizing the ways in which clinical cohorts deviate from a reference population, with respect to one or more biological features. In this paper, we extend the normative modeling framework with an approach for measuring the amount of heterogeneity in a cohort. This heterogeneity measure is based on the Representational Rényi Heterogeneity method, which generalizes diversity measurement paradigms used across multiple scientific disciplines. RCM-1 manufacturer We propose that heterogeneity in the normative modeling setting can be measured as the effective number of deviation patterns; that is, the effective number of coherent patterns by which a sample of data differ from a distribution of normative variation. We show that lower effective number of deviation patterns is associated with the presence of systematic differences from a (non-degenerate) normative distribution. This finding is shown to be consistent across (A) application of a Gaussian process model to synthetic and real-world neuroimaging data, and (B) application of a variational autoencoder to well-understood database of handwritten images.We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was less then 10-15, 5.4×10-8 and 3.5×10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina.

The ability to balance on one foot for a certain time is a widely used clinical test to assess the effects of age and diseases like peripheral neuropathy on balance. While state-space methods have been used to explore the mechanical demands and achievable accelerations for balancing on two feet in the sagittal plane, less is known about the requirements for sustaining one legged balance (OLB) in the frontal plane.

While most studies have focused on ankle function in OLB, can age and/or disease-related decreases in maximum hip abduction strength also affect OLB ability?

A two-link frontal plane state space model was used to define and explore the ‘feasible balance region’ which helps reveal the requirements for maintaining and restoring OLB, given the adverse effects of age and peripheral neuropathy on maximum hip and ankle strengths.

Maintaining quasistatic OLB required 50%-106% of the maximum hip abduction strength in young and older adults, and older patients with peripheral neuropathy. Effectiveness of a ‘hip strategy’ in recovering OLB was heavily dependent on the maximum hip abduction strength, and for healthy older women was as important as ankle strength.