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D increment, adjusted OR, 1.07; 95% CI 1.01, 1.14) and new-onset IFG (per SD increment, adjusted OR, 1.07; 95% CI 1.02, 1.14). Moreover, a stronger positive association between baseline ALP (per SD increment) with new-onset diabetes was found in participants with total homocysteine (tHcy)  less then  10 μmol/L (adjusted OR, 1.24; 95% CI 1.10, 1.40…[Read more]

In this issue of Neuron, Park et al. (2020) show that the brain forms unified cognitive maps of relational knowledge. The hippocampal-entorhinal region and medial prefrontal cortices spontaneously combine multiple, distinct rank orders to two-dimensional cognitive maps enabling flexible inference.In this issue, Laukoter et al., 2020 report that…[Read more]

In PD patients, peritoneal IL-17A positively correlated with CX3CL1 concentrations. PD-range glucose-stimulated, but neither identically treated Il17a-/- Il17f-/- nor T cells cultured with the ROS scavenger N-acetylcysteine enhanced mesothelial CX3CL1 expression. Our data delineate PD-range hypertonic glucose as a novel inducer of Th17…[Read more]

To mimic a hypothetical pathway for protein evolution, we previously tailored a monomeric protein (cyt cb562 ) for metal-mediated self-assembly, followed by re-design of the resulting oligomers for enhanced stability and metal-based functions. We show that a single hydrophobic mutation on the cyt cb562 surface drastically alters the outcome of met…[Read more]

The aim of the study was to assess the factors associated with mother-to-child transmission (MTCT) of HIV. The study design is a retrospective cohort. The population consisted of 323 HIV-positive mothers and their newborns, attended at the Perinatal Nucleus/HUPE-UERJ, municipality of Rio de Janeiro, in the period of 2007-2018. The average age of…[Read more]

Low back pain, and especially non-specific low back pain, is a common cause of presentation to the emergency department (ED). Although these patients typically report relatively high pain intensity, the clinical course of their pain and disability remains unclear. Our objective was to review the literature and describe the clinical course of…[Read more]